Sleep Disorders Drugs Flashcards
1
Q
Medications Known to Cause Insomnia: Antidepressants
A
- SSRIs
- SNRIs
- MAOIs
2
Q
Medications Known to Cause Insomnia: Antihypertensives
A
-Lipophilic Beta-Blockers
3
Q
Medications Known to Cause Insomnia: Bronchodilators
A
-Theophylline (similar to caffeine)
4
Q
Medications Known to Cause Insomnia: Nasal Decongestants
A
- Pseudoephedrine
- Phenylpropanolamine
5
Q
Medications Known to Cause Insomnia: Antiparkinsonian Drugs
A
-Levodopa
6
Q
Medications Known to Cause Insomnia: Corticosteroids
A
-Prednisone (many ppl find this incredibly stimulating)
7
Q
What do people take to try to improve their sleep?
A
- alcohol
- herbals
- dietary supplements
- homeopathic preparations
- melatonin
- OTC sleep aids
- sedating antidepressants
- sedative-hypnotics
8
Q
Medications that block alerting neurotransmitters are sleep promoting
A
- antihistamines
- anticholinergics
- serotonin, dopamine, and norepi blockers
- orexin blockers - suvorexant approved 2014
9
Q
- first orexin blocker
- approved 8/2014
- only clinical trial data available
- Schedule IV
- Warning for next day sedation
A
Suvorexant
10
Q
Sedating Antidepressants
A
- all are H1 blockers (non-scheduled)
- Doxepin FDA approved for insomnia (H1 blocker)
- Trazodone, Sinequan (most sedative), Adapin (doxepin), amitriptyline HCl, and mirtazapine (Remeron)
- trazodone most commonly prescribed (never use for depression b/c can’t get up to the dose needed for depression without knocking them out)
11
Q
BZs
A
- GABA
- facilitates GABA action on Cl- ion channel to hyperpolarize neurons
- multiple CNS effects include sedation, amnesia, anxiolysis, myorelaxation, and ataxia
12
Q
- BZ hypnotic
- txt for insomnia
- short half-life (1.5-5.5 hrs)
A
Triazolom
13
Q
- BZ hypnotic
- txt for insomnia
- t1/2 8.8 hrs
A
Temazepam
14
Q
- BZ hypnotic
- txt for insomnia
- t1/2 10-24 hrs
A
Estazolam
15
Q
- BZ hypnotic
- txt for insomnia
- t1/2 47-100 hrs
A
Flurazepam
