Sleep apnoea and neuromuscular respiratory disorders Flashcards

1
Q

Define sleep apnoea.

A

A temporary (10 seconds) cessation of breathing during sleep. Recurrent episodes of upper airway obstruction lead to apnoea.

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2
Q

Describe sleeping patterns in infants.

A

Natural apnoea before 36 weeks, after this increased regular respiration. Infants then begin going straight into REM sleep and have 50% REM and 50% NREM. Newborns spend 16-18 hours asleep. Sleep-wake states alternate in 3-4 hour cycles, then they start to adapt to light/dark and social cues. 6 month olds spend 14-15 hours asleep. They have 2 longer sleep periods at night and 1-2 daytime naps. 2 year olds spend 12 hours asleep and have 1 daytime nap. After 2 years naps usually disappear.

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3
Q

What happens to sleep patterns throughout life?

A

REM decreases and NREM increases. Total time asleep also decrease.

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4
Q

When is sleep most efficient?

A

In pre-pubescent children.

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5
Q

Describe sleep in adolescence.

A

Increased wakenings. Need more sleep but obtain less.

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6
Q

How can sleep be assessed?

A

Polysomnography (records brain waves, O2 levels in blood, HR, RR, leg and eye movements); direct behavioral observation; time-lapse video; movement sensors in cot mattress; O2/CO2 monitoring.

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7
Q

When do napping and enuresis become abnormal?

A

Age 3-5.

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8
Q

Is a 1 year old sleeping 8 hours per night without a nap normal or abnormal?

A

Abnormal.

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9
Q

When is REM onset of sleep normal?

A

First 3 months.

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10
Q

Which factors can cause excessive sleepiness?

A

Insufficient sleep, OSAS (obstructive sleep apnoae syndrome) or narcolepsy (falling asleep at inappropriate times, can be caused by orexin deficiency).

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11
Q

Define cataplexy.

A

A condition in which strong emotions such as laughter causes the patient to suddenly collapse although they are still conscious.

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12
Q

What is a hypnagogic hallucination?

A

A vivid/frightening hallucination experienced during the transition from wakefulness to sleep.

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13
Q

Define primary snoring.

A

Snoring without apnoea, hypoventilation, hypoxia, hypercarbia ( > blood CO2) and day time symptoms.

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14
Q

What is the morbidity associated with OSAS in children?

A

Failure to thrive, neurocognative effects/ADHD, systemic hypertension and Cor Pulmonale.

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15
Q

Contrast adult and child OSAS.

A

ADULT: daytime sleepiness, majority obese, no mouth breathing, more males, no enlarged tonsils, apnoea is obstructive pattern. CHILD: minority experience day time sleepiness or are obese, mouth breathing common, equal males and females, enlarged tonsils common, obstructive pattern is to hyperventilate.

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16
Q

What is the treatment for OSAS in children?

A

Adenotonsillectomy, CPAP (rarely), weight loss and avoid environmental tobacco smoke.

17
Q

Which respiratory disorders can cause apnoea?

A

Chronic neonatal lung disease, CF and asthma.

18
Q

Which neurological disorders can cause apnoea?

A

Cerebral palsy, Downs, Prader-Willi syndrome and DMD (death due to respiratory failure).

19
Q

What symptoms will adult OSAS patients have?

A

Snoring, unrefreshing sleep, daytime sleepiness (hypersomnolence) and poor daytime concentration.

20
Q

What are the pathophysiological causes of OSAS?

A

Muscle relaxation, having a narrow pharynx and obesity. Repeated closure of the upper airway causes snoring and O2 desaturation. Result is frequent microarousals so the brain is not properly rested - causes symptoms.

21
Q

What is the difference between apnoea and hypoapnoea?

A

Apnoea is a total obstruction and hypoapnoea is not a total obstruction.

22
Q

Why is OSAS important?

A

Impaired QOL, matiral dysharmony, > RTA, associations with hypertension, > stroke risk and > heart disease risk.

23
Q

What is the prevalence of OSAS in adults?

A

2% men and 1% women.

24
Q

How is OSAS diagnosed?

A

Clinical history, examination, Epworth questionnaire (11-24 score is significant) and overnight sleep study pulse oximetry (2 repetitive desaturations is sleep apnoea).

25
Q

What is the gold standard for diagnosis of OSAS?

A

Polysomnography, but in 99% of cases it is not needed to diagnose. Main difference between this and other tests is that it includes EEG (electroencephalogram).

26
Q

How is severity scored?

A

0-5 normal, 5-15 mild, 15-30 moderate and > 30 severe.

27
Q

How is sleep apnoea treated in adults?

A

Identify exacerbating factors: weight reduction, avoid alcohol, diagnose/treat underlying endocrine disorders, CPAP (keeps +ve pressure in throat, no O2 just air) and mandibular re positioning splint. Patients should not be driving until treated effectively.

28
Q

What is the prevalence of narcolepsy?

A

0.05%. Familial and associated with DRB11501 and DQB10602.

29
Q

What are the symptoms of narcolepsy?

A

Cataplexy, excessive daytime sleepiness, hypnagogic hallucinations and sleep paralysis. Last 2 as these patients go into REM sleep very quickly.

30
Q

What is the treatment of adult narcolepsy?

A

Modafinil, clomipramine (cataplexy) and sometimes sodium oxybate/xyrem.

31
Q

Define chronic ventilatory failure.

A

PCO2 > 6 kPa and PO2 bicarbonate. This is a chronic condition and so to stabilise blood pH in long term body takes bicarbonate from the kidneys.

32
Q

What are the causes of CVF?

A

Airways disease, chest wall abnormalities, respiratory muscle weakness and central hypoventilation.

33
Q

What are the symptoms of CVF?

A

Breathlessness, orthopnea, ankle swelling, morning headache, recurrent chest infections and disturbed sleep. FVC will be significantly less than predicted.

34
Q

What is the treatment for CVF?

A

Domiciliary non-invasive ventilation, O2 therapy (need to be careful as patient will probably use hypoxia central drive to breathe) and T-IPPV (tracheostimised intermittent positive pressure ventilation).