Sleep Flashcards

1
Q

What are the features of NREM sleep?

A

Reduced heart rate, blood pressure and tidal volumes

More NREM at beginning of the night

Synchronised, rhythmic EEG activity

Partial muscle relaxation of muscles

Reduced cerebral blood flow

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2
Q

What are the features of REM sleep?

A

Mostly at the end of the night

Cerebral blood flow increased

Atonic muscles

Narrative dreaming

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3
Q

What type of sleep is more important/deeper?

A

NREM sleep

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4
Q

Which type of sleep is similar to wakefulness?

A

REM sleep

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5
Q

What drugs might suppress REM sleep?

A

Tricyclics

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6
Q

What processes occur during NREM sleep that allow the cortex to recover?

A

Protein synthesis, cell division and growth

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7
Q

What processes occur during REM sleep?

A

Consolidation of memory

Maintains immunocompetence

Species with high metabolic rates have longer sleep times, suggesting importance in conserving energy

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8
Q

How does light train the body clock?

A

Uses retinal ganglion cells projecting to suprachiasmatic nucleus

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9
Q

What do parasomnias involve?

A

Involve abnormal movements, behaviors, emotions, perceptions, and dreams that occur while falling asleep, sleeping, between sleep stages, or during arousal from sleep.

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10
Q

What is parasomnia?

A

A disorder characterized by abnormal or unusual behaviour of the nervous system during sleep

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11
Q

What are some examples of NREM parasomnias?

A

Non-dreaming

Sleep walking

Sleep terrors

Sleep paralysis

Confusional arousal

Bruxism

Restless legs

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12
Q

What disease are REM sleep parasomnias associated with?

A

Parkinsons

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13
Q

What part of the night do REM parasomnias occur in??

A

Latter 1/3

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14
Q

What is narcolepsy?

A

Chronic neurological disorder involving the loss of the brain’s ability to regulate sleep-wake cycles normally

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15
Q

How does narcolepsy present?

A

Excessive daytime sleepiness - involuntary somnolence during eating/talking which may be severe, and impossible to resist

Cataplexy

Hypnagogic hallucinations

Sleep paralysis

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16
Q

What is cataplexy?

A

A medical condition in which strong emotion or laughter causes a person to suffer sudden physical collapse though remaining conscious

17
Q

In what percentage of people with narcolepsy is cataplexy a feature?

A

70%

18
Q

What measurement may be low in narcolepsy?

A

Hypocretin assessed with lumbar puncture

19
Q

How is narcolepsy investigated?

A

Multiple sleep latency test

Hypocretin level – low

Overnight polysomnography

20
Q

What are the two peaks of age of onset of narcolepsy?

A

Age 15

Age 36

21
Q

How is a multiple sleep latency test carried out?

A

4 twenty five minute naps are scheduled about two hours apart

Record of EEG, muscle activity and eye movement recorded

Measures time from the start of a daytime nap to the first signs of sleep (sleep latency)