Sleep Flashcards

1
Q

What does an EEG measure?

A

→ The combined activity of a large number of similarly orientated neurons

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2
Q

What does an EEG require?

A

→ synchronous activity across groups of cells

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3
Q

What does the amplitude of an EEG signal depend on?

A

→ how synchronous the activity of the neurons are

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4
Q

What is a large summed signal caused by?

A

→ tiny signals summed up to generate a large surface signal

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5
Q

What is a small summed signal caused by?

A

→ the same amount of excitation as a large signal

→ but at irregular intervals

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6
Q

What do EEG rhythms correlate with?

A

→ States of behaviours

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7
Q

What is high frequency and low amplitude associated with?

A

→ Alertness and wake

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8
Q

What is low frequency and high amplitude associated with?

A

→ Non dreaming sleep or coma

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9
Q

What are the two theories of how rhythms are generated during sleep?

A

→ There is a pacemaker that acts as a conductor (conductor telling everyone to clap)
→ mutual excitation and inhibition and neurons sync to what other neurons are doing (people clapping at random and syncing to each other)

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10
Q

What is theorised to be the pacemaker in the brain and why?

A

→ Thalamus

→ thalamic nuclei communicate with every cortical brain structure

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11
Q

Describe the hypothesis for slow frequency and high amplitude rhythms during sleep?

A

→ Thalamus acts as a gatekeeper it stops information getting to the brain during sleep
(like a spinning arm in an obstacle course)

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12
Q

Describe the hypothesis for fast frequency and low amplitude rhythms during wakefulness

A

→ the brain is attention grabbing to bind together regions needed for task execution

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13
Q

What is sensation like in non REM sleep?

A

→ dull or absent

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14
Q

What is thought like in non REM sleep?

A

→ logical

→ repetitive

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15
Q

What is movement like in non REM sleep

A

→ occasional

→ involuntary

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16
Q

What is sensation like in REM sleep?

A

→ vivid

→ internally generated

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17
Q

What is thought like in REM sleep?

A

→ vivid
→ illogical
→ bizarre

18
Q

What is movement like in REM sleep?

A

→ muscle paralysis

→ movement commanded by the brain but not carried out

19
Q

What is temperature, heart rate, breathing and energy consumption like in non REM sleep?

A

→ Decreased temperature
→ decreased heart rate
→ decreased breathing
→ decreased brain energy consumption

20
Q

What is temperature, heart rate, breathing and energy consumption like in REM sleep?

A

→ very low temperature
→ increased heart rate
→ increased breathing
→ very high brain energy consumption

21
Q

What kind of sleep do you begin with?

A

→ non REM sleep

22
Q

When do sleep cycles repeat?

A

→ every 90 minutes

23
Q

How many minutes of non REM do you need to progress into REM?

A

→ 30 minutes

24
Q

Why do we sleep?

A

→ getting rest -cognitive performance is increased after sleeping
→ adaptation to protect themselves and conserve energy

25
When you are awake what neurotransmitters are secreted and from where and what do they do?
→ ACh and orexin → basal forebrain and hypothalamus → increase excitatory activity and decrease synchronous firing
26
When you fall asleep what drives neural activity?
→ thalamus
27
What receptor activation promotes sleepiness?
→ adenosine
28
What does adenosine receptor activation cause?
→ Decrease heart and respiratory rate | → smooth muscle tone decrease
29
What are adenosine levels like during the day and night?
→ day - increasing | → night - rapidly drop
30
What stimulates adenosine release?
→ nitric oxide
31
What other factors contribute to sleepiness?
→ inflammatory factors
32
What is melatonin and when is it secreted?
→ compound that increases when there is a reduction in light
33
What is body temperature like during the day and night?
→ high during the day | → decreases at night
34
What hormone increases at night?
→ Growth hormone
35
What is cortisol like during the day and night?
→ Cortisol decreases during the day then increases before wakefulness
36
What are zeitgebers?
→ environmental cues such as the sun
37
What is the natural sleep cycle with no cues?
→ 24-25 hours
38
Where is the suprachiasmatic nucleus?
→ Located between the optic chiasm at the base of the hypothalamus
39
What does the suprachiasmatic nucleus do?
→ provides a circadian rhythm
40
What happens when the suprachiasmatic nucleus is inhibited?
→ The cycles are irregular
41
Describe how melatonin is inhibited?
→ Ganglion cells have a protein that is reactive to light → melanopsin ganglion cells transmit the activation to the suprachiasmatic nucleus → this inhibits the pineal gland →pineal gland is reponsible for the production of melatonin
42
Describe how melatonin is produced
→ no activation of melanopsin at night → SCN is not activated → pineal gland is not inhibited → produces melatonin