SLE Flashcards
examples of connective tissue diseases
Systemic Lupus Erythematosus Scleroderma Inflammatory Myositis Rheumatoid Arthritis Sjogren’s Syndrome Mixed Connective Tissue Disease Undifferentiated Connective Tissue Disease
what is SLE
A chronic, relapsing, inflammatory multisystem disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the immune system leading to expression of autoantibodies.
who is more likely to get SLE
women 15-45 y/o
AA, hispanics, asians
tests for SLE
ANA (99%)- sensitive NOT specific Anti-SSA(Ro)/SSB(La) Antibody- catches the 1% ANA - Anti-DNA-specific not senstive Anti-sm-specific Anti-RNP- specific
Anti-SSA(Ro)/SSB(La) Antibody associated with…
SLE, Sjögren’s Syndrome (70%), Neonatal lupus syndrome and congenital heart block
Periungual telangiectasia associated with…
SLE, Scleroderma, Inflammatory Myositis
Mucocutaneous Involvement in SLE most common
Nonscarring alopecia
malar rash
more common Cardiopulmonary Manifestations of SLE
pericarditis
pleuritis
Antiphospholipid Antibody Syndrome
Recurrent venous or arterial thrombosis Recurrent fetal loss** Thrombocytopenia Livedo Reticularis Valvular Heart Disease
what is scleroderma
A rare rheumatic disease characterized by deposition of fibrous connective tissue in the skin and other tissues accompanied by vascular lesions, especially in the skin, lungs, and kidneys
> 90% of patients have antecedent Raynaud’s phenomenon in…
scleroderma
what does CREST involve
scleroderma of the distal forearm
most involved organs in scleroderma
Skin
Raynaud’s phenomenon
Gastrointestinal
major GI symptoms of scleroderma
reflux and decreased motility
leading cause of death in scleroderma
Pulmonary causes:
interstital lung dz* scarring
pulm htn
