SLE

Question 1

X

Question 2

X

Question 3

X

Question 4

clinical features of SLE ?

Answer 4

malar rash,
arthritis - bilateral polyarthropathy with effusion affecting fingers, toes, and knees.

Question 5

Specific skin manifestation of SLE

Answer 5

purplish, non-blanching, reticulated rash caused by obstruction of the capillaries resulting in swollen venules
=Livedo reticularis

Raynaud phenomenon,

alopecia

Question 6

blood result in SLE ?

Answer 6

thrombocytopenia,
leukopenia

positive antinuclear antibody

Anti-dsDNA
Anti-Sm

Question 7

Unlike many autoimmune diseases systemic lupus erythematous (SLE) often becomes worse ?

Answer 7

pregnancy and the puerperium

Question 8

How does neonatal lupus erythrematous occur ?

Answer 8

maternal autoantibodies crossing the placenta

strongly associated with anti-Ro (SSA) antibodies

Question 9

neonatal lupus erythrematous complications ?

Answer 9

congenital heart block

Question 10

complication of SLE ?

Answer 10

unexpected pregnancy loss fittings
best with antiphospholipid antibody syndrome (APLS).

Question 11

x

Question 12

DIAGNOSIS OF SLE?

Answer 12

anti-double-stranded DNA (dsDNA) antibody and an anti-Smith (Sm) antibody with 99% specificity

Question 13

x

Question 14

Management of SLE ?

Answer 14

Basics
NSAIDs
sun-block

Hydroxychloroquine
the treatment of choice for SLE

Question 15

If internal organ involvement e.g. renal, neuro, eye then consider

Answer 15

prednisolone,

mycophenolate

cyclophosphamide