Skin structure & function Flashcards
What are the layers of the epidermis?
Keratin layer
Granular layer
Prickle cell layer
Basal layer
What are Blaschko’s lines?
Developmental growth pattern of skin (not following vessels, nerves, lymphatics)
Which cells migrate from neural crest?
Melanocytes
What type of cells are melanocytes?
dendritic cells
What substance do melanocytes convert to melanin pigment?
tyrosine
What are the two types of melanin pigment?
Eumelanin
Phaeomelann
What is vitiligo?
autoimmune dsease with loss of melanocyes
What is a malignant melanoma?
tumour of the melanocyte cell line
Where are Langerhan cells found?
PCL
Derms
Lymph nodes
Wha is the role of Langerhan cells n the immune system?
Antigen presenting cells
pick up anten in skin and circulate to lymph nodes via lymphatic system
Where are Merkel cells found?
Basal layer tween keratinocyes and nerve fibresbe
which gland is found adjacent to hair follice?
sebaceous gland
What are the three phases of hair growth?
Anagen (growing)
Catagen (involuting)
Teloen (resting)
What factors influence hair growth?
hormonal influences e.g. thyroxine, androgens
What diseases can affec he DEJ?
inherited skin fragility (mutation of protein in DEJ)
Acquired autoantibodies to protein in DEJ (pemphigus, pemphigoid, herpetiformis)