Skin, Nails and Hair Flashcards
What is the name of system that comprises of the skin and its associated components such as the hair and nails?
Integumentary
The skin is one of the largest _______ of the body, covering the majority of the outside area of the individual.
Organ
What are the functions of the skin? (8)
- Provides a protective barrier between the inner body and the external environment. It offers the first level of non-specific resistance.
- Regulates temperature. Sweating and increasing the blood flow to the skin cools the body. Decreasing the blood flow to the skin, and raising the hair on the surface of the skin, insulates it.
- Provides sensitivity via the skin’s sensory nerve endings and receptors so that temperature, pressure and pain can be detected.
- Allows the excretion of water, heat, some toxic waste and small amounts of salt.
- Allows the secretion of sebum.
- Provides a reservoir of blood that can be used elsewhere if required.
- Synthesizes vitamin D when stimulated by ultra-violet light.
- Allows the absorption of certain substances, although it is generally impermeable.
The skin is made up of three main layers. Name them.
The top layer of the skin is the epidermis** (epi- = above, dermis = skin). Under the epidermis is the **dermis**. The deepest part of the skin is the **subcutaneous layer (sub- = under, cutaneous = pertaining to the skin).
Epidermis offers the body a _______(a)_________? There are no ___(b)____ or ____(c)_____.
The epidermis is composed of 4 types of cells and has 5 layers. This complex cellular structure allows new cells to be continually produced to replace those that get worn away and facilitates the healing of damaged skin. The new cells are produced in the deepest epidermal layer and then push up to the surface. The top layer consists of flat, dead cells that are continually shed but replaced.
Epidermis offers the body a _(a)_waterproof protective coating_There are no _(b)_blood vessels_ or _(c)_nerve endings_.
a) waterproof protective coating.
b) blood vessels
c) nerve endings
The epidermis is composed of epithelium. The epidermal cells are closely packed and arranged in layers. There are 4 types of epidermal cell, name and describe them:
Keratinocytes
- make up about 90% of the epidermis.
- They produce keratin. Keratin is a protein that helps to waterproof and protect the skin.
- As cells make their way up through the epidermis, they form more and more keratin. By the time the cells reach the surface of the skin they are completely filled with keratin. This process is called keratinization.
Melanocytes
- Make up about 8% of the epidermis.
- Melanocytes produce melanin.
- Melanin is a brown-black pigment that contributes to skin colour.
- Melanocytes have long, thin projections that transfer granules of melanin to the keratinocytes.
Langerhans cells
- Originate in the bone marrow and migrate to the epidermis.
- they play a part in immune response because they have the ability to recognise certain antigens.
Merkel cells
- Are found in the deepest layer of the epidermis of hairless skin.
- They make contact with sensory neurons and are thought to have a part to play in the sensation of touch.
Keratinocytes
- Make up about 90% of the epidermis.
- They produce keratin.
- Keratin is a protein that helps to waterproof and protect the skin.
- As cells make their way up through the epidermis, they form more and more keratin. By the time the cells reach the surface of the skin they are completely filled with keratin. This process is called keratinization.
Melanocytes
- Make up about 8% of the epidermis.
- Produce melanin.
- Melanin is a brown-black pigment that contributes to skin colour.
- Have long, thin projections that transfer granules of melanin to the keratinocytes.
Langerhans cells
- Originate in the bone marrow and migrate to the epidermis.
- They play a part in immune responses because they have the ability to recognize certain antigens.
Merkel cells
- Are found in the deepest layer of the epidermis of hairless skin.
- They make contact with sensory neurons and are thought to have a part to play in the sensation of touch.
In most areas, the epidermis is about _____ thick and consists of 4 layers. Where the skin is exposed to the most friction (e.g. soles of the feet and palms of the hands) it consists of 5 layers and is ______ deep.
Name the 5 layers from deepest to surface and identify the extra layer found in areas of friction.
a) 0.1mm
b) 1-2mm
Stratum basale, Stratum spinosum, Stratum granulosum, Stratum lucidum (extra) and Stratum corneum.
This graphic represents the 5 layers of the epidermis. The surface layer is the stratum corneum. The deepest layer is the stratum basale.
Stratum basale
- (or stratum germinativum or basal cell layer) consists of just 1 layer of cells.
- It contains stem cells, melanocytes and Merkel cells (hairless skin only).
- The stem cells continually divide to produce keratinocytes, which push up towards the surface.
- Some stem cells migrate into the dermis and form sweat glands, sebaceous glands and hair follicles.
Stratum spinosum
- or prickle cell layer.
- This layer consists of 8-10 layers of cells, closely packed together.
- The long, thin projections of melanocytes extend among keratinocytes. This enables the melanocytes to transfer melanin to the keratinocytes.
Stratum granulosum
- (or granular layer)
- Consists of 3-5 layers of flattened keratinocytes, whose nuclei are in various stages of degeneration.
- These cells have begun the keratinization process. They contain granules of keratohyalin, a compound produced in the first step of keratin formation.
Stratum lucidum
- or clear layer)
- This layer only exits in places where the skin is thickest, such as on the palms of the hands and soles of the feet.
- It consists of 3-5 rows of clear, flat, dead cells. These cells contain a substance, formed from keratohyalin, which is eventually transformed into keratin.
Stratum corneum
- (or horny layer)
- The top stratum of the epidermis contains 25-30 rows of flat, dead cells.
- They are completely filled with keratin.
- These cells are continually shed and replaced by cells that are being pushed up from the lower strata.
- A protective barrier against light, heat, bacteria and many chemicals.