skin manifestation of systemic disease

Question 1

Behçet’s disease

Answer 1

Painful apthous ulcers in oral cavity ± genital mucous membranes

• erythema nodosum
• acneiform papules

Question 2

Buerger’s disease

Answer 2

Superficial migratory thrombophlebitis

• pallor
• cyanosis
• gangrene
• ulcerations
• digital resorptions

Question 3

Dermatomyositis

Answer 3

Periorbital and extensor violaceous erythema, heliotrope with edema, Gottron’s papules (violaceous flat-topped papules with atrophy), periungual erythema, telangiectasia, calcinosis cutis

Question 4

Polyarteritis nodosa

Answer 4

Subcutaneous nodules, stellate purpura, erythema, gangrene, splinter hemorrhages, livedo reticularis, ulceration

Question 5

Rheumatic fever

Answer 5

Petechiae, urticaria, erythema nodosum, rheumatic nodules, evanescent rash

Question 6

Scleroderma

Answer 6

Raynaud’s, nonpitting edema, waxy/shiny/tense atrophic skin (morphea), ulcers, cutaneous calcification, periungual telangiectasia, acrosclerosis, salt-and-pepper pigmentation

Question 7

Systemic lupus erythematosus

Answer 7

Malar erythema, discoid rash (erythematous papules or plaques with keratotic scale, follicular plugging, atrophic scarring on face, hands, and arms), hemorrhagic bullae, palpable purpura, urticarial purpura, patchy/diffuse alopecia, mucosal ulcers, photosensitivity

Question 8

Crohn’s Disease/Ulcerative colitis

Answer 8

Pyoderma gangrenosum, erythema nodosum, Sweet’s syndrome

Question 9

Acanthosis nigricans

Answer 9

An asymptomatic dark thickened velvety hyperpigmentation of flexural skin most commonly around the neck. Associated with diabetes, obesity and other endocrine disorders and malignancy. It is a cutaneous marker of tissue insulin resistance.

Question 10

Peutz- Jeghers

Answer 10

pigmented macules on lips/ oral mucosa GI adenocarcinoma