Skin Health Flashcards
What factors influence skin health and aging?
Heredity, sun exposure, the environment, health habits, and general lifestyles.
Explain the immune system and skin
Our immune system is a complex defence mechanism that protects the body from foreign substances.
The immune system is activated when antigens (foreign invaders) are identified.
Antibodies are molecules formed to fight and neutralize bacteria.
Langerhans cells, leukocytes, and T cells are all part of the immune system
Which cells are part of the immune system?
Langerhans cells and leukocyte cells & T cells
What are t-cells responsible for?
T-cells identify molecules that have foreign peptides and also help regulate immune response.
Think of how drinking tea can help regulate your immune response.
What are leukocytes & what are they responsible for?
Leukocytes are white blood cells that have enzymes that digest and kill bacteria and parasites. They also respond to allergies.
Which fluids nourish the skin?
Blood and lymph
What do arteries and lymphatic do?
They send essential materials for growth and repair throughout the body.
Networks of arteries and lymph vessels in the subcutaneous tissue send their smaller branches up to dermal papillae, follicles, and skin glands.
What does the health of the skin depend on?
The cellular membrane and the water holding capacity of the stratum corneum.
Give examples of lipids found in the stratum corneum and cell membranes.
Phospholipids Glycolipids Cholesterol Triglycerides Waxes
What are ceramides?
Ceramides are a group of waxy lipid molecules important to barrier functioning and water-holding capacity such as glycolipids.
Topical products containing ceramides and other lipids benefit wrinkled skin and expedite healing.
Cell recovery depends on:
Water
Cell replacement:
Regular cell turnover is necessary to keep the skin healthy.
Organs such as the skin, heart, liver, and kidney have their cells replaced every 6 to 9 months.
Cells of the bones are replaced every 7 years.
Elastin and collagen are not easily replaced by the body and the skin does not regain its once pliable shape after being stretched or damaged by UV.
Vitamin A and alpha hydroxyl acids (AHA’s) stimulate cell turnover and reduce visible signs of aging.
Damaged tissues can be repairs in two ways:
- Regeneration
2. Fibrosis
Regeneration:
The replacement of dead or damaged cells by the same type of cells as before.
Most skin injuries such as cuts or burns heal by regeneration
Fibrosis:
The replacement of damaged tissue with scar tissue.
Scar tissue is composed of collagen produced by fibroblasts.
Scar tissues hold an organ together but do not restore normal function.
(E.x healing of a sever cut)
Sun damage:
The sun and UV have the greatest impact on how the skin ages.
80-85% of aging is caused by sun exposure.
As we age, collagen and elastin weakens but it happens at a faster rate when the skin is exposed to UV.
UV reaches the skin in two different forms:
UVA and UVB radiation
What may be the results from exposure to UV?
Pigment dysfunction, wrinkles, sagging, breakdown of collagen and elastin, and skin cancer.
UVA Radiation
Known as aging rays
The longer wavelengths of UVA (320-400 nanometers) penetrate deep in the skin and cause genetic damage and cell death.
UVA Weakens the skins collagen and elastin fibres causing wrinkles and sagging in the tissues.
UVA is present all year and more prevalent than UVB
UVA can pass through glass windows or car windshields
UVB Radiation
Known as burning rays
Cause burning of the skin, tanning, aging, and cancer.
Stronger and more damaging to the skin and eyes compared to UVA
Contributes to the body’s synthesis of vitamin D
Melanin is designed to help protect the skin from the suns UV radiation, but melanin can be altered or destroyed when UV penetrates the skin
What is free radical damage
Free radicals are chemically active atoms or molecules with unpaired electrons
(They have an uneven number of electrons and unbalanced electrical charge)
They steal electrons from other molecules which leaves them damaged.
When these molecules take electrons from compounds from the body such as proteins, lipids or DNA, this destabilizes and oxidizes the once healthy molecules and creates more free radicals.
It’s a chain reaction of cellular destruction
Free radicals are generated by many factors such as exposure to UV, unhealthy foods, chemicals, smoke and trauma from medical treatments
Red and inflamed skin is a sign of free radical damage
What does the melanin pigment do?
Absorbs UV to help keep cells from being damaged
Antioxidants
Vital to neutralize the chain reaction by donating their electrons to stabilize the free radical electrons.
Protein, enzymes and vitamins are all antioxidants.
What does nicotine in tobacco cause?
Weakening of the blood vessels and small capillaries that supply blood to the tissues, causing decreased circulation.
The tissues are deprived of essential oxygen and the skin may appear yellow, grey, or dull.
Lack of oxygen and nutrients accelerates aging