Skin Cancer Flashcards
UV-A effects
Produces reactive oxygen species causing oxidative DNA and protein damage
Skin ageing
Potentates UV-B carcinogenesis
UV-B effects
Sunburn
Direct damage of skin cell DNA
Most common skin cancers
- BCC
- SCC
- Malignant melanoma
Which skin conditions require a 2ww referral
MM
SCC
A-E examination of melanoma
A: asymmetrical
B: irregular border
C: irregular pigmentation
D: >6mm diameter
E: evolution - change in size, colour and elevation
Oozing, bleeding, itching, altered sensation
Premalignant skin conditions
Actinic keratosis
Bowens disease
Character of BCC
Rarely metastasises
Character of SCC
Can metastasise
When should BCCs be referred to haematology
Head and neck lesions
Surgical margins for each skin cancer
BCC: 3-5mm SCC: 2-4mm Melanoma in situ: 5mm Melanoma <2mm deep: 1cm Melanoma >2mm deep: 2cm
Treatment options for skin cancers
Sunscreen Retinoids 5-FU Photodynamic therapy Cryotherapy Surgical excision