Skin Cancer Flashcards

1
Q

UV-A effects

A

Produces reactive oxygen species causing oxidative DNA and protein damage
Skin ageing
Potentates UV-B carcinogenesis

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2
Q

UV-B effects

A

Sunburn

Direct damage of skin cell DNA

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3
Q

Most common skin cancers

A
  1. BCC
  2. SCC
  3. Malignant melanoma
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4
Q

Which skin conditions require a 2ww referral

A

MM

SCC

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5
Q

A-E examination of melanoma

A

A: asymmetrical
B: irregular border
C: irregular pigmentation
D: >6mm diameter
E: evolution - change in size, colour and elevation
Oozing, bleeding, itching, altered sensation

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6
Q

Premalignant skin conditions

A

Actinic keratosis

Bowens disease

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7
Q

Character of BCC

A

Rarely metastasises

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8
Q

Character of SCC

A

Can metastasise

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9
Q

When should BCCs be referred to haematology

A

Head and neck lesions

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10
Q

Surgical margins for each skin cancer

A
BCC: 3-5mm
SCC: 2-4mm
Melanoma in situ: 5mm
Melanoma <2mm deep: 1cm
Melanoma >2mm deep: 2cm
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11
Q

Treatment options for skin cancers

A
Sunscreen
Retinoids
5-FU
Photodynamic therapy
Cryotherapy
Surgical excision
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