Skin bio Flashcards
sensory nerve dysfunction can cause what?
itch, dysesthetic pain/burning, hyperesthesia
After sensory nerve disfunction has occured, insensitivity to injury can be a consequence. what are some common?
neuropathic ulcers, trigeminal trophic syndrome
What is the role of the melanin?
protects against damage from UV radiation
Abnormal skin pigment is associated with what disease?
albinism
What is predisposed if immune surveillance is damaged?
infection, autoimmunity, cancer
If failure to regulate temp, what can result?
hypo- hyper thermia
If circulation is altered, what occurs?
infarction (emboli, vasculitis)
if communication function is damaged or altered, what is the result?
itching, insensitivity
If photoprotection is damaged, what could be the result?
cancer, photoaging
Which layers of skin fulfill the barrier and support roles?
epi: barrier => dermis:structural & nutritional
What are the 4 results of impairing the skin as a barrier fxn?
dehyrdration, infection, injury, inflammation
What disease is associated with the barrier fxn damage?
atopic dermatitis
What are 4 results of the skin’s immune fxn damaged?
infection, cancer, inflam/autoimmune diseases, allergic rxns
What disease is associated with immune fxn disorder of epidermal adhesion due to autoantibodies of skin adhesion molecules?
autoimmune bullous diseases (erosions, blisters)=> bullous pemphigoid, pemphigus vulgaris
Disease associated with anti-desmosome antibodies
pemphigus vulgaris
disease associated with anti-hemidesmosome Abs
bullous pemphigoid
When repair of wounds fail, what is susceptible?
chronic skin ulcers, infection risks, mutations leading to cancer
Who is most prevalent to have XP?
children due to susceptibility of UV radiation causing them not to live to adults
What mutation is associated with hypohidrotic ectodermal dysplasia?
EDAR gene
What is the pathophys of the hypohidrotic ectodermal dysplasia?
EDAR mutatation leading to improper interaction of mesoderm and ectoderm development
How will a person present who has hypohidrotic ectodermal dysplasia?
unable to regulate temp (overheats) and abnormal hair follicles, sweat glands and teeth
Local thermoregulatory dysfxns can occur. What is a disease brought on by cold leading to episodic digitial ischemia?
Raynauds phenomenon
What is a disease that is associated with injured vessels that disrupt circulation leading to cutaneous necrosis/ulceration?
small vessel vasculitis
Anti-phospholipic Ab syndrome may present as what?
widespread cutaneous necrosis
