Skin bio

Question 1

sensory nerve dysfunction can cause what?

Answer 1

itch, dysesthetic pain/burning, hyperesthesia

Question 2

After sensory nerve disfunction has occured, insensitivity to injury can be a consequence. what are some common?

Answer 2

neuropathic ulcers, trigeminal trophic syndrome

Question 3

What is the role of the melanin?

Answer 3

protects against damage from UV radiation

Question 4

Abnormal skin pigment is associated with what disease?

Answer 4

albinism

Question 5

What is predisposed if immune surveillance is damaged?

Answer 5

infection, autoimmunity, cancer

Question 6

If failure to regulate temp, what can result?

Answer 6

hypo- hyper thermia

Question 7

If circulation is altered, what occurs?

Answer 7

infarction (emboli, vasculitis)

Question 8

if communication function is damaged or altered, what is the result?

Answer 8

itching, insensitivity

Question 9

If photoprotection is damaged, what could be the result?

Answer 9

cancer, photoaging

Question 10

Which layers of skin fulfill the barrier and support roles?

Answer 10

epi: barrier => dermis:structural & nutritional

Question 11

What are the 4 results of impairing the skin as a barrier fxn?

Answer 11

dehyrdration, infection, injury, inflammation

Question 12

What disease is associated with the barrier fxn damage?

Answer 12

atopic dermatitis

Question 13

What are 4 results of the skin’s immune fxn damaged?

Answer 13

infection, cancer, inflam/autoimmune diseases, allergic rxns

Question 14

What disease is associated with immune fxn disorder of epidermal adhesion due to autoantibodies of skin adhesion molecules?

Answer 14

autoimmune bullous diseases (erosions, blisters)=> bullous pemphigoid, pemphigus vulgaris

Question 15

Disease associated with anti-desmosome antibodies

Answer 15

pemphigus vulgaris

Question 16

disease associated with anti-hemidesmosome Abs

Answer 16

bullous pemphigoid

Question 17

When repair of wounds fail, what is susceptible?

Answer 17

chronic skin ulcers, infection risks, mutations leading to cancer

Question 18

Who is most prevalent to have XP?

Answer 18

children due to susceptibility of UV radiation causing them not to live to adults

Question 19

What mutation is associated with hypohidrotic ectodermal dysplasia?

Answer 19

EDAR gene

Question 20

What is the pathophys of the hypohidrotic ectodermal dysplasia?

Answer 20

EDAR mutatation leading to improper interaction of mesoderm and ectoderm development

Question 21

How will a person present who has hypohidrotic ectodermal dysplasia?

Answer 21

unable to regulate temp (overheats) and abnormal hair follicles, sweat glands and teeth

Question 22

Local thermoregulatory dysfxns can occur. What is a disease brought on by cold leading to episodic digitial ischemia?

Answer 22

Raynauds phenomenon

Question 23

What is a disease that is associated with injured vessels that disrupt circulation leading to cutaneous necrosis/ulceration?

Answer 23

small vessel vasculitis

Question 24

Anti-phospholipic Ab syndrome may present as what?

Answer 24

widespread cutaneous necrosis