skin and systemic disease

Question 1

Necrobiosis Lipoidica, what condition do you get it in?

Answer 1

diabetes

Question 2

what is Necrobiosis Lipoidica?

Answer 2

Firm, waxy, red / brown or yellow plaques on anterior shin.

Associated with increase risk of ulceration

Question 3

Acanthosis Nigricans, what conditions?

Answer 3

Diabetes, addisons, malignancy (DAM)

Question 4

Purple brow, indurated waxy plaques on anterior shins

Answer 4

pre tibial myxoedema

Question 5

Pyoderma gangrenosum, which conditions?

Answer 5

IBD and rheumatoid

Question 6

what does kaposis sarcoma look like?

Answer 6

purple brown nodules

Question 7

when do you get kaposis sarcoma?

Answer 7

HIV/ immunosuppression

Question 8

SJS and TENS are variant of the same disease. how do you diferentiate between them?

Answer 8

the extent of skin involvement. steven johnston is less than 10 percent involvement, whereas TENS is over 30 percent

Question 9

why are sjs and tens potentially life threatening ?

Answer 9

there is widespread erythema and blistering of the skin and mucosal surfaces. the blisters then merge, undergo necrosis and large sheets of skin are lost

Question 10

most common drug reactions causing TENS or sjs

Answer 10

penicillin
NSAIDS
anti convulsants - lamotrigine and valproate

Question 11

management of SJS and TENS

Answer 11

cessation of causative drug
supportive care
emollients
IV Ig