Skin and Soft Tissue Disorders and Hernias Flashcards
Risk factors for melanoma
- FHx melanoma
- Sun exposure
- Previous dysplastic nevi or atypical moles
Physical exam s/s suggestive of malignant lesions
- Ulceration
- Bleeding
- Change in size
- Variation in pigmentation (5-10% of melanomas are not pigmented)
- ABCD rule (asymmetry, border irregularity, color variation, diameter, dark black color)
- Regional LN involvement
When to perform incisional biopsy on a skin lesion
- > 2-3cm
2. Contiguous w/important structures such as the face
Mgmt given skin biopsy results
- Benign skin lesions = no further tx
- Basal cell CA = Local excision b/c of recurrence may be locally invasive. If excision has negative margins then no further tx reqd. May ALSO use topical 5-FU or radiation
- SCC (Bowen’s disease) = Local excision w/1cm margin for tumors >4mm b/c recurrence is common. Lesions >10mm often involve local LN’s and LN dissection is req’d if nodes are palpable. 5-FU or radiation may ALSO be used here.
- In situ melanoma = excise to ensure 0.5-1cm margin
- Dysplastic nevus = req only minimal adequate excision (no margin req’d)
Factors affecting survival in melanoma
- TNM stage
- Ulceration in the primary lesion (33% reduction in survival)
- Lesions on face/trunk = worse prognosis
- Women do better than men
Mgmt of malignant melanoma depending on depth
- 0.7mm depth = local control w/1cm margin excision down to the fascial plane. CXR, CBC, LFT’s are appropriate. Follow up b/c recurrence in 5%
- 1.6mm depth = warrants 2cm margin with LN dissection if nodes are palpable b/c of 40% LN mets. DO NOT resect NONpalpable nodes b/c no added benefit and risk of lymphedema and wound complications. (If nodes are palpable then a sentinal LN biopsy is warranted)
- 4.5mm depth = poor prognosis with death most likely from metastatic disease. Excise w/2-3cm margin. Excise LN’s b/c of tendency to erode skin and become infected and painful. CT/MRI of brain necessary to r/o brain mets. Interferon CTX.
- Axillary LAD = regional LN dissection warranted. 75% chance recurrence in the next 5yrs in pts with mets. CXR, LFT’s, CT abd, MRI brain should be done to evaluate mets/staging. Interferon CTX increases survival by 40%
Tx of melanoma with distant mets
- Stage IV dz should be treated with systemic tx w/combo drugs OR dacarbazine
- SOLITARY lung/brain mets may be tx w/resection
- Rads may relieve pain from bone mets
Superficial, spreading (NOT invading) skin lesion often involving the face
Lentigo maligna melanoma. Mgmt involves local excision with narrow margins b/c of face involvement. Precursor = Hutchinson freckle. Mgmt of Hutchinson freckle involves observation
Malignant melamona on the sole of the foot
Poorer prognosis than other locations. Often are thicker. More common in dark-skinned people.
Subungual malignant melanoma
- Excision of a portion of the nail in continuity w/the lesion
- Re-excision following diagnosis involves amputation at the DIP joint
Anal melanoma traits
- Poor prognosis (100% 5yr mortality)
- Lesions occur at the dentate line
- thicker lesions req abdominoperineal resection of the anorectum (lower local recurrence)
- Regional LN dissection only indicated for positive inguinal nodes
Hx of malignant melanoma s/p resection, abd distention, N/V, SBO
Melanoma recurrence in peritoneal cavity causing SBO. Poor prognosis w/palliative tx possible for solitary lesions but most pts die
Slow growing firm painless mass on anterior thigh that is larger than benign tumors +/- regional adenopathy
Soft tissue sarcoma. a/w hx of therapeutic radiation exposure or axillary LN dissection, trauma w/persistent mass (misdiagnosed as hematoma)
Mgmt of sarcoma
- Excisional biopsy for masses 3cm. Large defect makes closure complex w/potential for seeding other compartments with tumor cells
- Core needle bx is accurate in dx in certain centers
- FNA is NONdiagnostic and thus NOT USEFUL
- Frozen section does NOT allow for reliable dx
Prognosis of sarcoma
- high rate of mets to liver, lung, bone, brain (req’s metastatic workup)
- Bone pain should prompt bone scan