Skeletal Muscle Paralytics - Trachte Flashcards
What receotrs and neurotransmitter mediates skeletal muscle contraction?
Nicotinic receptors
Acetylcholine
What can you use anticholinesterases for?
Treating myasthenia gravis
Treating poisoning
What toxin blocks nicotinic receptors?
alpha-bungarotoxin - from snakes
<p>
| What 3 drugs block acetylcholine degradation?</p>
<p>
| Neostmine, pyridostigmine, edrophonium</p>
What toxin blocks ACh release?
Botulinum toxin
What toxins bock nicotinic receptors?
d-turbocurarine
Mivacurium
What drug blocks ca-induced Ca release?
Dantrolene
What drug is used to diagnose myasthenia gravis
edrophonium
What is the toxicity of acetylcholinesterase?
SLUDGE
sweating, lacrimation, urination, diarrhea, Gi, emesis
Competetive blocker of nicotinic receptors?
turbocurarine
block Na influx, depolarization, contraction
Drug that depolarizes the end plate of the muscle and leads to chronic Na infux (then fasciculations and flaccid paralysis)
succinylcholine
Toxic effects of nicotinic receptor antagonists?
Apnea, histamine release, cardiovascular collapse
Malignant hyperthermia caused by halothane and succinylcholine (1 in 15,000)
-treatment is dantrolene (dantrium) - inhibits Ca2+ release from sarcoplasmic reticulum by blocking the Ryanodine receptor (Calcium-induced calcium release)
Advantage of Mivacurium over Tubocurarine?
It is shorter acting, if that’s what you want
Why should you check to see if someone has butyrlcholinesterase before giving them succinylchoine?
Why avoid it in burn victims?
That is what breaks it down, if they dont have enough of the enzyme then the drug will last WAY too long.
Burned muscle increases the concentration of nicotinic receptors resulting in excessive potassium release in response to succinylcholine
