Skeletal muscle Flashcards
What are sarcomeres
Contractile units of skeletal and cardiac muscle
What are sarcomeres held in register by
Cross connections at the level of every z disk and the middle of each sarcomere formed by intermediate filaments
What do thick and thin filaments appear as in fibres
Striations
What do lots of myofibrils make
muscle fibre
What is muscle fibre
Syncytium (lots of precursor cells fused to form a fibre)
What is a fascicle
Fibre bundle
What does the amount of force developed by a sarcomere depend on
The degree of overlap between thick and thin filaments
What’s the force a muscle can develop dependent on?
The starting length
What is the length tension relationship
1) at full stretch, few of the myosin heads have access to actin in the thin filament and the force is weak
2) At optimal length, all of the myosin filaments have access to actin and the force is maximal
3) at full contraction, the ends of the thin filament get in each others way and the force is reduced
What’s the actin and myosin like at full stretch and what is the force like?
Few of the myosin heads have access to actin in the thin filament
-force is weak
What are the actin and myosin like at optimal length
-what’s the force like?
All of the myosin filaments have access to actin
-force is maximal
What’s the actin and myosin like at full contraction?
-What is the force like?
Ends of the thin filament get in each others way
-force is reduced
What stain is used to stain muscle?
Goldner trichrome
What color are muscle fibers after staining
brown-purplish
What color is connective tissue after staining
Green
What is endomysium
- What does it surround
- What does it connect to
Loose connective tissue with some delicate and strong fibers
- Surrounds each muscle fibre
- Connects to basement membrane
What is perimysium
Mixed connective tissue, some dense, some loose