skeletal muscle Flashcards

1
Q

what are the 4 primary types of tissue

A

muscle, nervous, epithelial, connective

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2
Q

what is bone made of and function of the material

A

calcium for strength

collagen for flexibility

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3
Q

the 3 types of muscle

A

skeletal, smooth, cardiac

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4
Q

where is smooth muscle found

A

in hollow organs and tubes (blood vessels)

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5
Q

what are 2 ways of categorising muscle

A

striated or unstriated

voluntary or involuntary

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6
Q

4 key features of skeletal muscle

A

multinucleated, large, elongated, cylindrically shaped

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7
Q

what are myofibrils and what are they made of

A

the contractile elements of fibre made of thick myosin and thin actin filaments

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8
Q

what is a sarcomere

A

the functional unit of skeletal muscle found between 2 Z lines

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9
Q

the 2 roles of titin

A

stabilises the thick filaments in relation to the thin filaments
acts as a spring to increase elasticity

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10
Q

where is titin found

A

extending from the M line to the Z lines

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11
Q

what is the structure of myosin (including heads)

A

2 polypeptide tails wrapped around each other with globular heads
each globular head has an actin binding site and an ATPase site

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12
Q

what is the function and structure of tropomyosin

A

thread like molecule that wraps around actin filament, blocking binding sites for myosin cross bridge formation

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13
Q

what is the function and structure of troponin

A

stabilises tropomyosin, made up on 3 polypeptide units, C/I/T

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14
Q

what is the sarcoplasmic reticulum

A

fine network of interconnected compartments surrounding each myofibril

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15
Q

where is calcium stored

A

in the lateral sacks of the sarcoplasmic reticulum

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16
Q

what are T tubules and why are they important

A

perpendicular extensions of the cell membrane running into the centre of the muscle fibre, they allow action potential to spread down them since they are continuous to surface membrane

17
Q

series of events that trigger calcium release

A
  1. action potential spreads down T tubule
  2. voltage dependent DHP receptor is activated
  3. DHP changes confirmation and is connected to ryanodine receptor in the sarcoplasmic reticulum
  4. ryanodine receptor allows Ca2+ to enter sarcoplasm
18
Q

what is muscle relaxation dependent upon

A

calcium reuptake into the sarcoplasmic reticulum