Sitagliptin Phosphate (Antidiabetic)

Question 1

What is the brand name of Sitagliptin Phosphate?

Answer 1

Januvia

Question 2

What tablet strengths of Januvia are available?

Answer 2

25 mg, 50 mg, 100 mg

Question 3

What is the FDA approved indication for Januvia?

Answer 3

As an adjunct to diet and exercise to improve glycemic control and patient with type two diabetes mellitus as monotherapy or as combination therapy with metformin or peroxisome proliferator-activated receptor gamma agonist when the single agent does not provide adequate glycemic control

Question 4

What is the dosage of Januvia?

Answer 4

The normal adult dose is 100 mg once daily.

In patients with renal impairment, (CrCl 30-50 mL/min) 50 mg once daily
In patients with renal impairment, (CrCl >30mL/min) 25 mg once daily

Question 5

What should the providers monitor when their patient is on sitagliptin Phosphate?

Answer 5

Fasting Blood Glucose, HbA-1c

Question 6

What is the mechanism of action for Januvia?

Answer 6

Sitagliptin inhibits the dipeptidyl peptidase-4 (DDP-4) enzyme.

Question 7

What are the drug interactions for Januvia?

Answer 7

May increase the peak drug concentration of digoxin.

Question 8

What are the contraindications of Januvia?

Answer 8

• Contraindicated in patients have shown hypersensitivity to any ingredients.
• Use with caution in patients with renal insufficiency.
• The use of sitagliptin phosphate with drugs which may cause hypoglycemic reactions, including sulfonylurea or insulin, has not been adequately studied & this combination should be avoided.
• Pregnancy Category B

Question 9

What are the adverse effects of Januvia?

Answer 9

Nasopharyngitis

Question 10

What should the pharmacist tell the patient when counseling them on the use of Januvia?

Answer 10

• May be taken without regard to meals.
• Closely follow recommended dietary and exercise instructions.
• Quarterly HbA1-c testing should be performed.
• If a dose is missed, take it as soon as possible but do not double doses.