SIRS and MODs ppt Flashcards
Systemic Inflammatory Response Syndrome (SIRS)
&
Multiple Organ Dysfunction Syndrome (MODS)
1 Cause Sepsis = Hypoperfusion
2 Organs mainly affected
1. Heart 2. Lungs
SIRS def and patho
Triggers
-Mechanical tissue trauma: burns, crush injuries, surgical procedures
-Abscess formation: intraabdominal, extremities
-Ischemic or necrotic tissue: pancreatitis, vascular disease, MI
-Microbial invasion: bacteria, viruses, fungi
-Endotoxin release: gram-negative bacteria
-Global perfusion deficits: postcardiac resuscitation, shock states
-Regional perfusion deficits: distal perfusion deficits
Systemic inflammatory response syndrome (SIRS) is a systemic inflammatory response to a variety of insults
Generalized inflammation in organs remote from the initial insult
MODS = End of Continuum…(death)
Multiple organ dysfunction syndrome (MODS) is failure of two or more organ systems
Homeostasis cannot be maintained without intervention
Results from SIRS
NO DIC, No decubitus
Relationship of Shock, SIRS, and MODS
SIRS and MODSPathophysiology
**DIC = bleeding = no more platelets
Formation of microemboli. **
Organ and metabolic dysfunction
Hypotension
Decreased perfusion
Formation of microemboli
Redistribution or shunting of blood (VQ mismatch)
SIRS and MODSPathophysiology #Always Lungs compromised 1st
Respiratory system
Alveolar edema
Decrease in surfactant
Increase in shunt – circulation passing your lungs w/o oxygenation
V/Q mismatch (increase in shunting???)
End result: ARDS (Hard fluid filled lungs)
RF -> inflammatory mediators (cytokines) = more aggressive
SIRS and MODSPathophysiology: cardiovascular system
Myocardial depression and massive vasodilation (drop BP -> leads to drop CO)
Edematous – increased edema = increased capillary permeability = venous pooling
Results in drop SVR and BP
Baroreceptors respond to enhance CO
Fluid shift - Albumin and fluid move out of blood vessels
NEURO
SIRS and MODSPathophysiology Neuro = Hypoxia= Hypo-perfusion= Confusion, Irritable, lethargic, Combative, Comatose
Neurologic system
Mental status changes due to hypoxemia, inflammatory mediators, or impaired perfusion
Often early sign of MODS
Renal System
SIRS and MODS
Acute kidney injury (AKI)
Hypoperfusion : ↓ u/o, ↑ Cr
Release of mediators
Activation of renin-angiotensin-aldosterone system # Holds on to water#
Nephrotoxic drugs, especially antibiotics
ABX: Mycins
GI
SIRS and MODSPathophysiology# Early stage: Blood is shunted out of GI
GI system
Motility decreased: abdominal distention and paralytic ileus
Decreased perfusion: risk for ulceration and GI bleeding
Potential for bacterial translocation from GI to circulatory system.
Intervention
Even with MODS, we want to feed the patient to maintain the stomach.
SIRS and MODS
Gluconeogensis , increased BS
Hematologic system
1. DIC – causes simultaneous micro-clotting, combined with extra fibrinolysis, and decreased platelets.
2. Electrolyte imbalances
3. Metabolic acidosis
4. Hypoxia – decreased tissue oxygen perfusion -> lactic acidosis.
Hypermetabolic state
Hyperglycemia-hypoglycemia – glycogenesis ↑BS, insulin resistant
Insulin resistance
Catabolic state – fatty acid burns and ketones as fuel-> hypermetabolic state. Lean mass decreases.
Liver dysfunction – no albumin # key role in maintaining the plasma-oncotic pressure.
Lactic acidosis – infection, without oxygen
Interprofessional Care SIRS and MODS
Prevention and treatment of infection
Aggressive infection control strategies to decrease risk for nosocomial infection
Strict asepsis
Assess need for invasive lines
Once an infection is suspected, institute interventions to control source
BURN pt. – early debridement of burns to avoid infection by microorganism.
Interprofessional care SIRD and MODS - Oxygenation
Maintenance of tissue oxygenation
Decrease O2 demand and increase O2 delivery
Sedation
Mechanical ventilation
Analgesia
Rest
Interprof. care - Nutirion
Nutritional and metabolic needs
Goal of nutritional support: preserve organ function
Total energy expenditure is often increased 1.5 to 2.0 times
Use of the enteral route is preferred to parenteral nutrition
Monitor plasma transferrin and prealbumin levels to assess hepatic protein synthesis
Provide glycemic control
SIRS and MODS - support the failing organs
Support of failing organs
ARDS: aggressive O2 therapy and mechanical ventilation
DIC: appropriate blood products
Renal failure: continuous renal replacement therapy or dialysis