SÍNTESIS DE ÁCIDOS GRASOS Flashcards

1
Q

Dónde sucede la síntesis de ácidos grasos?

A

Citosol

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2
Q

Mediante qué se genera el citrato?

A

Acetil-CoA

+

Piruvato

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3
Q

Cuáles son las vías para generar NADPH?

A

Vía de las pentosas

Enzima Málica

Isocitrato Deshidrogenasa

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4
Q

Qué intermediario es necesario para la SÍNTESIS de ácidos grasos?

A

Malonil-CoA

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5
Q

Cuál es el paso limitante de la SÍNTESIS DE ÁCIDOS GRASOS?

A

Formación de Malonil-CoA

Acetil-CoA Carboxilasa (ACC)

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6
Q

Quién inhibe a la ACC?

A

Altas concentraciones de Insulina

Altas concentraciones de citrato

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7
Q

Quién inhibe a la ACC?

A

Altas concentraciones de Glucagón

Altas concentraciones de AMP y palmitato

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8
Q

Enzima que rompe el citrato en ACETIL-CoA y OXALACETATO?

A

Citrato liasa

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9
Q

Qué enzima ayuda a que oxalacetato entre de nuevo en la mitocondria?

A

Enzima MÁLICA

Produce NADPH

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10
Q

Cofatores de la acetil-CoA Carboxilasa?

A

ATP

Biotina

CO2

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11
Q

Qué se necesita para formar PALMITOIL-COA?

A

8 acetil-CoA

14 NADPH

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12
Q

Enzima limitante del ciclo?

A

Acetil-CoA Carboxilasa (ACC)

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13
Q

La ACC con qué se INACTIVA?

A

Fosforilada

La activa insulina y la inactiva glucagón

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