Sinh Ly Tieu Hoa Flashcards
Don vi chuc nang cua gan
Tieu thuy gan:
- hinh tru: giua la tn trù tam tieu thuy, xung quanh la be te bao gan (2 lop te bao)- tieu quan mat nam giua
Tb gan nam giua :tieu quan mat va mau tròng mao mach dang xoang
- giua cac tb gan: tm cua, dm gan, ong mat, bach huyet! T
- tm trung tam tieu thuy- tm gan - tm chu duoi
Mm dang xoang: tb noi mo- kuffer- khoang Disse- thog thuong voi mach bach huyet!
Chuc nang he thong tuan hoan gan
Du tru mau
He dem
Loc mau
Du tru mau/gan
- tm cua 1l mau + dm gan 400 ml: 29% CO
- he mach cua gan ( tm, mm, dm) chua: 650 ml! Tang ap luc nhi P, anh huong nguoc lai gan, mau co chua trong tm va mm kieu xoang len den 1l
Chuc nang dem|gan
Mao mach kieu xoang co tinh tham rat manh
Dd tu he tieu hoa- nhanh xhog vao khoang ke cua gan- khong tang qua cao trong tuan hoan sau bua an- gan chuyen hoa va phong thoch vao mau voi nong do nhat dinh
Chuc nang loc| gan
Tb kuffer : loc vk tu tm cua ( mau cua duong tieu hoa)–) rat it vk qua khoi hang rao nay
Hau qua cua ap suat cao trong tm gan
Tm gan-chu: 0
Tm cua: 8 mmHg
–) suc can voi luu luong mau tu tm cua la khog dang ke
Tb gan xo–) mm bi hep–) tro ngai dong mau u tm cua vao gan!
Ap luc tm gan tang–) tang luu luong bach huyey–) tham qua bao gan: co truong
Bai tiet mat/gan
Moi tb gan deu bai tiet mat–) ong nho den lon–) omc–) ta trang va tui mat - co that òddi
Du tru mat trong tui mat
Luong mat tiet mot ngay: 700-1100ml
Tui mat: 40-70ml
Tui may du tru mat trog 12h do kha nang co dac mat( hap thu chu dong nuoc, nacl₫
Y
Co che tiet mat sau an
Tui mat co bop: -cholecystokiniin - day x Gian truong luc co oddi: - px mat-ruot - nhu dong ruot non
Thanh phan mat
Muoi mat(50%) Bili Lẽci Choles Muoi khoang
Chole 1-2 g/d! Ko tan trong nuoc, tan tròn micelle
Tao acid may nguyennphat- thu phat
Acid mat nguyen phat ( a cholic, chenodeoxycholic)–) gan glycin va taurin tao muoi mat
Trog ta trang: tao acid mat thu phat ( a deoxycholic, a lithocholic)
Chuc nang muoi mat
- nhu tuong hoa: tang dien tich tx men lipase va mo
- hoa tan mo/nuoc
Ruot: tai nong do nhat dinh–) tao hat micelle( ua nuoc quay ra ngoai). San p thoai hoa cua mo nhanh chong nhap vao hat micelle!
Micel tan trong nuoc- bo bam chai tb ruot- hap thu mo qua bieu mo vak hach bach huyet
Khong muoi mat, hau qua
40% luon lipid khong dũo hap thu
Nhing hao thu cac chat tan trong mo, db la vitamin a d e k! Vit k : tong hop yeu to dong mau
Chuyen hoa mat
Mat :
- tai hap thu 90-95% hoi trang, tm cua, tro lai gan–) bai tiet lai! L
Muoi mat tai hap thu cang nhieu, thi bai tiet cang nhieu
- phan con lai ra duog tieu tieu hao
Bai tiet bilirubim
hC: -globin - hem --) biliverdin --) bili gT (tu do) - tan tròng mo-gan pro --) chuyen hoa o gan: 80% a glucuronix 10% sulfat 10% othwr --) bil tt: tan trong nuoc: vk chuyen hoa thanh urobilinogen - tai hap thu - uro: nũo tieu, sterco: phan