Sinal Pharmacodynamics Flashcards
Ultimate goal of pharmacologic therapeutics:
to achieve a desired beneficial effect with minimal adverse
effects
Pharmacokinetics
the quantitative study and characterization of the time course of
drug concentrations in the body
pharmacokinetics uses what to model physiological processes
simplified mathematical representations to model
complex physiological processes (absorption, distribution,
metabolism, excretion)
pharmacokinetics describes what
the time course of drug concentrations in the body
the major determinant of patient drug response is
pharmacokinetic differences
drug distribution involves
drug movement from the blood to the target site
drug absorption involves
movement of the drug from point of administration to the blood/circulation
drug elimination involves
movement of the drug out of the blood, through the metabolism and ultimately out of the body
3 facets of pharmacokinetics
absorption; distribution; elimination
two types (routes) of drug administration
Local & Systemic
systemic
(non-local)
two types of systemic administration
enteral; parenteral
enteral
desired effect is systemic (non-local), substance is given via the
digestive tract
parenteral
desired effect is systemic (non-local), drug is given by route other than digestive tract
topical
local effect, substance is applied directly where its action is desired
