signaling pathways of endocrine hormones Flashcards

1
Q

FSH

A

cAMP

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2
Q

LH

A

cAMP

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3
Q

ACTH

A

cAMP

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4
Q

TSH

A

cAMP

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5
Q

CRH

A

cAMP

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6
Q

hCG

A

cAMP

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7
Q

ADH (V2 receptor)

A

cAMP

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8
Q

MSH

A

cAMP

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9
Q

PTH

A

cAMP

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10
Q

calcitonin

A

cAMP

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11
Q

GHRH

A

cAMP

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12
Q

glucagon

A

cAMP

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13
Q

histamine

A

cAMP (H2 receptor)

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14
Q

BNP

A

cGMP

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15
Q

ANP

A

cGMP

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16
Q

EDRF

A

endothelium derived relaxing factor - eg NO- cGMP

17
Q

GnRH

A

IP3

18
Q

Oxytocin

A

IP3

19
Q

ADH (V1 receptor)

A

IP3- these are the receptors in blood vessels that are responsible for vasopressor action

20
Q

angiotensin II

A

IP3

21
Q

Gastrin

A

IP3

22
Q

Progesterone

A

intracellular receptor

23
Q

estrogen

A

intracellular receptor

24
Q

testosterone

A

intracellular receptor

25
Q

cortisol

A

intracellular receptor

26
Q

aldosterone

A

intracellular receptor

27
Q

T3/T4

A

intracellular receptor

28
Q

vitamin D

A

intracellular receptor

29
Q

insulin

A

receptor tyrosine kinase. MAP kinase.

30
Q

igf-1

A

receptor tyrosine kinase. MAP kinase.

31
Q

fgf

A

receptor tyrosine kinase. MAP kinase. fibroblast growth factor. e.g.: in achondroplasia there is constitutive activation of FGFR3 actually inhibits chondrocyte proliferation.

32
Q

pdgf

A

receptor tyrosine kinase- MAP kinase

33
Q

egf

A

receptor tyrosine kinase- MAP kinase

34
Q

prolactin

A

nonreceptor tyrosine kinase. jak/stat pathway. acidophils and cytokines.

35
Q

immunomodulators (IL2, IL6, IFN)

A

nonreceptor tyrosine kinase. jak/stat pathway. acidophils and cytokines.

36
Q

GH

A

nonreceptor tyrosine kinase. jak/stat pathway. acidophils and cytokines.

37
Q

G-CSF

A

nonreceptor tyrosine kinase. jak/stat pathway. acidophils and cytokines.

38
Q

EPO

A

nonreceptor tyrosine kinase. jak/stat pathway. acidophils and cytokines.

39
Q

thrombopoietin

A

nonreceptor tyrosine kinase. jak/stat pathway. acidophils and cytokines.