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Pharmacology > Side Effects Of Drugs > Flashcards

Side Effects Of Drugs Flashcards

1
Q

Physostigmine, Echothiphate

A

Cataract

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2
Q

Pilocarpine

A

Accomodation
Headache
Retinal detachment

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3
Q

Cefoperazone

A

3rd generation
Due to MTT group
Hypoprothrombinemia causing bleeding (vit K prophylaxis 10mg twice/week)
Disulfuram like reaction therefore C/I with alcohol

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4
Q

Echothiophate

A

Iris cyst

Cataract

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5
Q

Monobactams

A

Hepatotoxic in children

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6
Q

Hexamethonium

A

Postural hypotension

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7
Q

Aminoglycosides

A
  • Nephrotoxic, max with Neomycin and min with streptomycin
  • Ototoxicity max with kanamycin, amikacin, neomycin and min with netilmycin
  • Neuromuscular toxicity max with Neomycin and min with Tobramycin
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8
Q

Mirabegron

A

Headache
HTN
UTI
Nasopharyngitis

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9
Q

Brimonidine

A

Sedation/Drowsiness

Apnea in neonates

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10
Q

Dipivefrine

A

Conjunctival pigmentation

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11
Q

Beta 2 agonists

A

Tremors - Most common
Palpitations
Hyperglycaemia
Hypokalemia

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12
Q

Dopamine

A

Arrythmia

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13
Q

Selective Alpha 1a,b,d blockers

A

Postural hypotension

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14
Q

Ipratropium

A

Dry mouth - Most common
Glaucoma
Urinary retention

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15
Q

Reserpine, Tetrabenazine, Valbenazine

VMAT2 inhibitors

A

Hypotension
Depression
Parkinsonism

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16
Q

Bacitracin

A

Bone marrow suppression

Nephrotoxicity

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17
Q

Cycloserine

A

Seizures
Psychosis
Peripheral Neuropathy

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18
Q

Cefotetan

A

2nd generation
Due to MTT group
Hypoprothrombinemia causing bleeding (vit K prophylaxis 10mg twice/week)
Disulfuram like reaction therefore C/I with alcohol

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19
Q

Naltrexone

A

Hepatotoxicity

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20
Q

Naloxone

A

Release of catecholamines leading to:
HTN
Arrythmia
Pulmonary edema

21
Q

Methadone

A

QT prolongation

Anticholinergic side effects

22
Q

Fentanyl

A

Wooden chest syndrome

23
Q

Timolol

A

Nasolacrimal duct obstruction

24
Q

Selective Alpha 1a blockers
Tamsulosin
Silodosin

A

Ejaculation failure
Retrograde ejaculation
Floppy iris

25
Q

Penicillin in Secondary Syphilis

A

Jarisch Hershheimer Reaction:
Fever
Rash Arthralgia
Worsening of cutaneous lesion

26
Q

Na fill in

A

Neutropenia

27
Q

Oxacillin

A

Hepatotoxic

28
Q

Ceftriaxone

A

Thrombocytopenia
Pseudolithiasis
⬆️ PPB - Kernicterus in new born

29
Q

Methicillin

A

Interstitial Nephritis

30
Q

Beta lactams

A 
Rash
Anaphylaxis
Hypoprothrombinemia
Disulfuram like reaction
Nephrotoxicity 
Pseudomembranous enterocolitis
31
Q

Colistin

A

Nephrotoxicity

Neuromuscular toxicity

32
Q

Cefomandole

A

2nd generation
Due to MTT group
Hypoprothrombinemia causing bleeding (vit K prophylaxis 10mg twice/week)
Disulfuram like reaction therefore C/I with alcohol

33
Q

Vancomycin

A

Red man syndrome due to histamine release
Nephrotoxicity
Ototoxicity

34
Q

Moxolactam

A

3rd generation
Due to MTT group
Hypoprothrombinemia causing bleeding (vit K prophylaxis 10mg twice/week)
Disulfuram like reaction therefore C/I with alcohol

35
Q

Meperidine/Pethidine

A

Anticholinergic side effects like
Mydriasis
Tachycardia
(large iv dose)

36
Q

Oxacillin

A

Hepatotoxicity

37
Q

Cephaloridine

Cefalothin

A

Nephrotoxicity :

Renal tubular necrosis

38
Q

Daptomycin

A

Myopathy
Neuropathy
Allergic pneumonitis

39
Q

Tetracycline

A
  • Severe pain and inflammation if given im route
  • Nausea, vomiting
  • Esophagitis
  • Nephrotoxic except Tigecycline, Doxycycline, Minocycline
  • Fanconi syndrome
  • Hepatotoxic
  • Bone growth abnormality
  • Yellow discolouration of teeth
  • Diabetes insipidus
  • Photosensitivity
40
Q

Erythromycin

A
  • Cholestatic jaundice
  • Hypertrophic pyloric stenosis
  • Enzyme inhibition/Pgp inhibition causing drug interaction and C/I with Theophylline
  • QT prolongation: Erythromycin >Clarithromycin>Azithromycin
  • Diarrhea due to Motilin receptor agonist action
41
Q

Telithromycin

A

Hepatotoxicity

Neuromuscular toxicity

42
Q

GnRH agonists intermittent dose

A

Multiple gestation
Ovarian hyper stimulation syndrome
Ovarian cancer

43
Q

Linezolid

A

Bone marrow suppression
Serotonin syndrome
Mitochondrial toxicity leading to lactic acidosis, optic neuritis, peripheral neuropathy

44
Q

Streptogramins

A

Injection site reaction

45
Q

Clindamycin

A

Pseudomembranous enterocolitis

Neuromuscular toxicity

46
Q

Lefamulin

A

QT prolongation

Raised ALT/AST

47
Q

Chloramphenicol

A

Bone marrow suppression

Grey baby syndrome

49
Q

GnRH agonists continuous dose

A

Osteoporosis
Vaginal atrophy
Impotence
Gynaecomastia

Pharmacology (3 decks)

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