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Side Effects Of Drugs Flashcards

1
Q

Physostigmine, Echothiphate

A

Cataract

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2
Q

Pilocarpine

A

Accomodation
Headache
Retinal detachment

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3
Q

Cefoperazone

A

3rd generation
Due to MTT group
Hypoprothrombinemia causing bleeding (vit K prophylaxis 10mg twice/week)
Disulfuram like reaction therefore C/I with alcohol

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4
Q

Echothiophate

A

Iris cyst

Cataract

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5
Q

Monobactams

A

Hepatotoxic in children

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6
Q

Hexamethonium

A

Postural hypotension

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7
Q

Aminoglycosides

A
  • Nephrotoxic, max with Neomycin and min with streptomycin
  • Ototoxicity max with kanamycin, amikacin, neomycin and min with netilmycin
  • Neuromuscular toxicity max with Neomycin and min with Tobramycin
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8
Q

Mirabegron

A

Headache
HTN
UTI
Nasopharyngitis

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9
Q

Brimonidine

A

Sedation/Drowsiness

Apnea in neonates

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10
Q

Dipivefrine

A

Conjunctival pigmentation

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11
Q

Beta 2 agonists

A

Tremors - Most common
Palpitations
Hyperglycaemia
Hypokalemia

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12
Q

Dopamine

A

Arrythmia

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13
Q

Selective Alpha 1a,b,d blockers

A

Postural hypotension

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14
Q

Ipratropium

A

Dry mouth - Most common
Glaucoma
Urinary retention

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15
Q

Reserpine, Tetrabenazine, Valbenazine

VMAT2 inhibitors

A

Hypotension
Depression
Parkinsonism

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16
Q

Bacitracin

A

Bone marrow suppression

Nephrotoxicity

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17
Q

Cycloserine

A

Seizures
Psychosis
Peripheral Neuropathy

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18
Q

Cefotetan

A

2nd generation
Due to MTT group
Hypoprothrombinemia causing bleeding (vit K prophylaxis 10mg twice/week)
Disulfuram like reaction therefore C/I with alcohol

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19
Q

Naltrexone

A

Hepatotoxicity

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20
Q

Naloxone

A

Release of catecholamines leading to:
HTN
Arrythmia
Pulmonary edema

21
Q

Methadone

A

QT prolongation

Anticholinergic side effects

22
Q

Fentanyl

A

Wooden chest syndrome

23
Q

Timolol

A

Nasolacrimal duct obstruction

24
Q

Selective Alpha 1a blockers
Tamsulosin
Silodosin

A

Ejaculation failure
Retrograde ejaculation
Floppy iris

25
Penicillin in Secondary Syphilis
Jarisch Hershheimer Reaction: Fever Rash Arthralgia Worsening of cutaneous lesion
26
Na fill in
Neutropenia
27
Oxacillin
Hepatotoxic
28
Ceftriaxone
Thrombocytopenia Pseudolithiasis ⬆️ PPB - Kernicterus in new born
29
Methicillin
Interstitial Nephritis
30
Beta lactams
``` Rash Anaphylaxis Hypoprothrombinemia Disulfuram like reaction Nephrotoxicity Pseudomembranous enterocolitis ```
31
Colistin
Nephrotoxicity | Neuromuscular toxicity
32
Cefomandole
2nd generation Due to MTT group Hypoprothrombinemia causing bleeding (vit K prophylaxis 10mg twice/week) Disulfuram like reaction therefore C/I with alcohol
33
Vancomycin
Red man syndrome due to histamine release Nephrotoxicity Ototoxicity
34
Moxolactam
3rd generation Due to MTT group Hypoprothrombinemia causing bleeding (vit K prophylaxis 10mg twice/week) Disulfuram like reaction therefore C/I with alcohol
35
Meperidine/Pethidine
Anticholinergic side effects like Mydriasis Tachycardia (large iv dose)
36
Oxacillin
Hepatotoxicity
37
Cephaloridine | Cefalothin
Nephrotoxicity : | Renal tubular necrosis
38
Daptomycin
Myopathy Neuropathy Allergic pneumonitis
39
Tetracycline
* Severe pain and inflammation if given im route * Nausea, vomiting * Esophagitis * Nephrotoxic except Tigecycline, Doxycycline, Minocycline * Fanconi syndrome * Hepatotoxic * Bone growth abnormality * Yellow discolouration of teeth * Diabetes insipidus * Photosensitivity
40
Erythromycin
* Cholestatic jaundice * Hypertrophic pyloric stenosis * Enzyme inhibition/Pgp inhibition causing drug interaction and C/I with Theophylline * QT prolongation: Erythromycin >Clarithromycin>Azithromycin * Diarrhea due to Motilin receptor agonist action
41
Telithromycin
Hepatotoxicity | Neuromuscular toxicity
42
GnRH agonists intermittent dose
Multiple gestation Ovarian hyper stimulation syndrome Ovarian cancer
43
Linezolid
Bone marrow suppression Serotonin syndrome Mitochondrial toxicity leading to lactic acidosis, optic neuritis, peripheral neuropathy
44
Streptogramins
Injection site reaction
45
Clindamycin
Pseudomembranous enterocolitis | Neuromuscular toxicity
46
Lefamulin
QT prolongation | Raised ALT/AST
47
Chloramphenicol
Bone marrow suppression | Grey baby syndrome
49
GnRH agonists continuous dose
Osteoporosis Vaginal atrophy Impotence Gynaecomastia

Pharmacology (3 decks)

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