side effects

Question 1

HAM SEs most common in

Answer 1

low potency antipsychotics, TCAs

Question 2

serotonin syndrome

Answer 2

confusion, flushing, diaphoresis, tremor, myoclonic jerks, hyperthermia, hypertonicity, rhabdomyolysis, renal failure, death

Question 3

EPS 3 categories

Answer 3

parkinsonism
akathisia
dystonia

Question 4

EPS most commonly with

occur within?

Answer 4

FGAs

hours-days of starting medication

Question 5

hyperprolactinemia occurs most commonly with

Answer 5

with high-potency FGAs and risperdal

Question 6

NMS s/s

Answer 6

AMS, fever, tachycardia, HTN, tremor, ^CK, “lead pipe” rigidity

Question 7

NMS can be caused by ? in what time frame

Answer 7

any antipsych, ^ with high potency FGAs
at any time
20% mortality

Question 8

common cytochrome P450 enzymes

Answer 8

CYP34A, CYP2D6, CYP1A2, CYP2C9, CYP2C19

Question 9

important cyt P450 inducers (lower med levels)

Answer 9

tobacco (1A2)
Carbamazepine (Tegretol) 1A2, 2C9, 34A
Barbs 2C9
St. John’s wort 2C9, 3A4

Question 10

important cyt P450 inhibitors (raise med levels)

Answer 10

fluvoxamine (1A2, 2C19, 3A4)
fluoxetine (2C19, 2C9, 2D6)
paroxetine (2D6)
duloxetine (2D6)
sertraline (2D6)