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Schizophrenia > Side Effects > Flashcards

Side Effects Flashcards

1
Q

Aripiprazole

A

Little weight gain
Least sedating
PO and LAI

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2
Q

Maintena

A

Gluteal injection
14 day oral overlap
Monthly injection

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3
Q

Aristada

A

Gluteal injection
21 day oral overlap
Monthly or 6 week injection

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4
Q

1st gen class side effects

A 
EPS
QTc prolongation 
Prolactin elevation 
Dermatologic
Photosensitivity
Blue gray skin
Orthostatic hypotension
Altered thermoregulation

BBW: dementia

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5
Q

2nd gen class side effects

A 
Metabolic syndrome 
QTc prolongation 
Blood dyscrasia/ agranulocytosis 
Seizure threshold 
Anticholinergic
Sedation
Prolactin elevation (2)

BBW: dementia

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6
Q

Can skip right to clozapine when?

A

Severely suicidal
EPS Extreme
History of violence
Substance abuse

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7
Q

B52 is?

A

LAI haloperidol and lorazepam

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8
Q

Cannot mix IM with what drug

A

Olanzapine

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9
Q

Asenapine

A 
2nd gen 
Sublingual only
Black cherry taste
Can't eat or drink for ten minutes after
HIGH RISK QTC PROLONGATION
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10
Q

Long half life

A

Brexpiprazole

Cariprazine

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11
Q

Agranulocytosis

A

Clozapine

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12
Q

Orthostatic hypotension

A

Iloperidone

Slowly titrate

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13
Q

Rems monitoring ANC only

A

Clozapine

Olanzapine

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14
Q

When dose greater than 600mg/day seizure risk

A

Clozapine–must add anti epileptic

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15
Q

If metabolic gets bad?

A

DO NOT STOP CLOZAPINE–we change the metabolic syndrome not clozapine

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16
Q

Severe hepatic impairment don’t use this drug

A

Iloperidone

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17
Q

LAI injection must observe for at least three hours bc respiratory suppression

A

Olanzapine

Pamoate zyprexa relprev

18
Q

DRESS drugs reaction with eosinophilia and systemic symptoms

A

Dermatologic condition
Rash topically
But affects organs inside
Fatal if not caught

19
Q

DRESS DRUGS

A

Olanzapine

Ziprasidone

20
Q

OROS ghost tablet in stool

A

Paliperidone

21
Q

Invega sustenna

A

Paliperidone
No PO overlap needed
Monthly injections
Deltoid or glute

22
Q

Invega Trinza

A

Paliperidone
Every 3 month injection
MUST BE ON SUSTENNA FOR 3 MONTHS BEFORE

23
Q

Quetiapine

A

Very sedating

Weight gain

24
Q

Short acting injections

A 
Chlorpromazine 
Haloperidol 
Fluphenazine
Olanzapine 
Ziprasidone
25
Q

Long acting injections

A 
Fluphenazine
Haloperidol 
Aripiprazole
Olanzapine 
Risperidone 
Paliperidone
26
Q

Gluteal injection only

A

Olanzapine

Aripiprazole

27
Q

EPS

A

Extra pyramidal symptoms

Use AIMS to confirm before stopping meds QUICKLY

28
Q

Neuroleptic malignant syndrome NMS

A 
High potency drugs
Onset: any time early treatment 
Rapidly over 24-72 hrs
Labile BP
Confusion 
Increased muscle tone/rigidity 
Increased WBC CPK LFTs
Treatment: DC antipsychotic (bromocriptine if need)
Rechallenge with different drug (sga)
29
Q

Sedation

A

Chlorpromazine
Clozapine
Thioridazine

30
Q

EPS

A

Fluphenazine
Haloperidol
Perphenazine
Thioxene

31
Q

Anticholinergic

A

Chlorpromazine
Clozapine
Thioridazine

32
Q

Orthostasis

A

Chlorpromazine
Clozapine
Thioridazine
Iloperidone

33
Q

Weight gain

A

Olanzapine
Clozapine
Chlorpromazine

34
Q

Prolactin

A 
Risperidone 
Paliperidone 
Perphenazine
Thioxene
Fluphenazine 
Haloperidol
35
Q

Cardiovascular effects

A 
Haloperidol 
Chlorpromazine 
Clozapine 
Iloperidone 
Ziprasidone
36
Q

LAI doesn’t need oral overlap

A

Paliperidone

Olanzapine

37
Q

Acute dystonia

A

Painful prolonged muscle contraction of whole body trunk included
24-96 hrs after dose/drug change
High potency drugs or high dose fga
Treat: anticholinergics IM and benzo IM

38
Q

Pseudo-Parkinson’s

A

Bradykinesia, tremor, pill rolling
1-2 weeks after drug/dose change
Treatment: anticholinergics

39
Q

Akathisa

A

Restlessness, pacing, shuffling
Hrs to days after drug/dose change
High potency fga, aripiprazole,risperidone
Treatment: propranolol

40
Q

Tardive diskinesia

A 
Tongue thrusting, chewing, lip smacking, twisting rocking IRREVERSIBLE 
LATE
high potency or high dose fga
Treatment: none must prevent 
Anticholinergics MASK symptoms

Schizophrenia (3 decks)

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