Side Effects Flashcards
Lamotrigine (Lamictal)
BW: SJS/TEN, valproic acid will increase lamotrigine levels
SE: alopecia (selenium and zinc), somnolence, tremor, diplopia, blurred vision
decreased concentrations with CYP inducers: Carbamazepine, Phenytoin, Phenobarbital, Rifampin
Levetiracetam (Keppra)
Warning: Psych reactions, SJS, increase BP
SE: irritability, dizziness, weakness
NO DRUG INTERACTIONS
CrCl < 80: decrease dose
IV to PO 1:1
Topiramate (Topamax)
Warning: metabolic acidosis, oligohidrosis, nephrolithiasis, glaucoma, hyperammonemia, cisual problems, FETAL harm
SE: somnolence, WEIGHT LOSS, anorexia, memory/attention loss
Monitor: IOP, electrolytes (bicarb)
Valproic Acid (Depakote)
BW: hepatic failure, fetal harm (neural tube defects and decreased IQ score)
CI: hepatic disease
Warning: hyperammonia (carnitine), thrombocytopenia,
SE: alopecia (Selenium and Zinc), weight GAIN, PCOS, edema
increases the level of lamotrigine
Carbamazepine (Tegretol)
BW: SJS/TEN - HLA-B*1502 test in Asian decent, aplastic anemia, agranulocytosis
CI: myelosuppression, MAO inhibitors, NNRTI
Warning: SIADH - hyponatremia, hypothyroidism, FETAL HARM
AUTOINDUCER: range 4-12 mcg/mL
Oxcarbamazepine (Trileptal)
Warning: SJS/TEN with HLA-B*1502, Hyponatriemia
SE: somnolence, visual disturbances, abdominal pain, diplopia
CrCl < 30 start at 300 mg daily
Lacosamide (Vimpat)
Warning: increased risk of arrhythmia by prolonged PR
SE: dizziness, diplopia, blurred vision
Phenytoin (Dilantin)
BW: do NOT exceed 50 mg/min = cardiac arrhythmias
Warning: Purple Glove Syndrome (Extravasation) HLA-B*1502, fetal HARM
Toxicity: nystagmus, ataxia, diplopia/blurred vision, confusion
Chronic: Gingival hyperplasia, hair growth, hepatotoxicity, peripheral neuropathy, increased BP
Ethosuximide (Zarontin)
used for absence seizures
Warning: SJS, blood dyscrasias
SE: N/V, abdominal pain, weight LOSS
Gabapentin (Neurotin)
Warning: Angioedema
SE: somnolence, peripheral edema, weight GAIN, mild euphoria
