Side Effects Flashcards
SSRI
Warning: QTc prolongation (less with sertraline), SIADH/hyponatremia, fall risk, bleeding
SE: somnolence, insomnia, nausea, weakness, tremor, dizziness, decreased libido, erectile dysfunction
SNRI
Warning: SIADH/hyponatremia, falls, bleeding
SE from NE: tachycardia, hypertension, dilated pupils, dry mouth, sweating, constipation
SE: somnolence, insomnia, nausea, weakness, tremor, dizziness, decreased libido, erectile dysfunction
Secondary Amine TCA (Nortriptyline)
Cardiotoxicity: QTc prolongation, orthostasis, tachycardia
Anticholinergic: dry mouth, constipation, blurred vision, urinary retention, confusion
SE: sedation, weight gain, vivid dreams, risk of falls
Tertiary Amine TCA (Amitryptiline)
Cardiotoxicity: QTc prolongation, orthostasis, tachycardia
Anticholinergic: dry mouth, constipation, blurred vision, urinary retention, confusion
* higher risk*
SE: sedation!!!, weight gain!!!, vivid dreams, risk of falls
Buproprion (Wellbutrin)
CI: seizure disorder, history of anorexia/bulemia
Warning: neuropsychiatric ADR
SE: dry mouth, CNS stimulation (insomnia, restlessness), tremors/seizures, weight loss
Mirtazapine (Remeron)
Warning: anticholinergic effect, QTc prolongation, blood dyscrasias, CNS depression
SE: Sedation, increased appetite, weight gain
Trazodone
Sedation, Orthostasis, Sexual dysfunction, priapism
1st generation antipsychotics
Warning: QTc prolongation, Anticholinergic effects, CNS depression, EPS, NMS, hyperprolactinemia
SE: sedation, dizziness, anticholinergic effects
Ariprazole (Abilify)
Akathisia, Activation (more than sedation), QTc prolongation
***lower risk of metabolic syndrome and weight gain
Clozapine (Clozaril)
REMS for neutropenia and agranulocytosis (to start therapy ANC must be > or = 1500)
SE: seizures!!, constipation, metabolic syndrome, hypersalivation (sialorrhea)
Lurasidone (Latuda)
Somnolence, EPS, nausea
**lower risk of of metabolic syndrome
Olanzapine (Zyprexa)
Somnolence, metabolic syndrome, orthostasis
Paliperidone (Invega)
Hyperprolactin, EPS, Metabolic Syndrome, QTc prolongation
Quetiapine (Seroquel)
Somnolence, metabolic syndrome, orthostasis
**lower EPS symptoms
Risperidone (Risperdal)
Hyperprolactin, EPS, QTc prolongation
Ziprasidone (Geodon)
QTc prolongation!!!
Lithobid
Lithium
Warning: Serotonin Syndrome
SE: GI upset, cognitive effects, tremor, thrist, weight gain, hypothyroidism, cardiac abnormalities, hypercalcemia, blue-grey skin
Toxicity:
> 1.5 mEq/L - ataxia, tremor, vomiting
> 2.5 mEq/L - CNS depression, arrhythmia, seizures
Ritalin (IR)
Methylphenidate
SE: insomnia, decreased appetite, weight loss, HA, irritability
Stimulants for ADHD
CI: use with MAO inhibitors
Warning: High HR and BP, serious CV events, new onset of pyschosis, serotonin syndrome
Concerta OROS
Methylphenidate
SE: insomnia, decreased appetite, HA, weight loss, irritability
GHOST tablet
Adderall
Dextroampetamine/Ampetamine
BW: misuse can cause sudden death
***do not take with acidic foods like juice!
Vyvanse
Lisdexamfetamine
Low abuse potentional!
All normal stimulant side effects
Strattera
Atomoxetine
BW: suicide
CI: MAO inhibitor use
Warning: aggressive behavior, psychosis
SE: decreased appetite, somnolence, insomnia, dry mouth, hypertension, tachycardia
Kapvay
Clonidine ER
Dose-dependent CV events (hypotension, bradycardia, orthostatis)
SEDATION
**do not discontinue abruptly due to rebound HTN
SE: dry mouth, somnolence, dizziness, constipation
