SIADH Flashcards
1
Q
Define
A
- Inappropriate secretion from posterior pituitary
2. Ectopic production
2
Q
Pathophysiology
A
+ADH->excessive reabsorption of water in distal neprhon, not inhibited by hyponatremia.
Plasma osmolality falls
3
Q
Calculate plasma osmolality
A
2 X sodium + urea + glucose
4
Q
Diagnosis made
A
Comparison of plasma oxmolality and urine->urine osmolarity inappropriately elevated
5
Q
Drug mechanism
A
- +ADH
- Potentiate effects
- Unknown mechanism
6
Q
Causes
A
1. Drugs AntiD, antipsychotics Chemotherapy Omeprazole 2. Post-operative stress 3. CNS Infections Stroke Trauma Neurosurgery 4. Pulmonary Pneumonia TB, empyema Status asthmaticus 5. Malignant Neoplasm Lymphoma Leukemia Mesothelium Ewings sarcoma 6. Psychoses 7. Vasopressin or oxytocin
