Show I've Done My Research

Question 1

What I would be working on

Answer 1

3 Ph2 studies:

• 2 HBV (Hep B)
• 1 Remdesivir

1 study in start-up; 2 in maintenance

Question 2

Pipeline: Emerging Virus (COVID)

Answer 2

Veklury® (remdesivir for injection)

• Outpatient COVID-19
• Ph3

Remdesivir inhaled form (GS-5734)
Outpatient COVID-19
- Ph1

Question 3

Pipeline: HBV (Hepatitis B)

Answer 3

1. Selgantolimod TLR-8 agonist (GS-9688)
   - HBV cure research program
   - Ph2
   - agonist = a substance/chemical which initiates a physiological response when combined with a receptor
2. Oral PD-L1 small molecule (GS-4224)
   - HBV cure research program
   - Ph1
   - small molecule = a low molecular weight (< 900 daltons) organic compound that may regulate a biological process

Question 4

What is Hepatitis B?

Answer 4

An inflammatory liver condition caused by viral infection (virus) HBV (Hep B). Preventable by vaccine.

Question 5

What is Hepatitis D?

Answer 5

Only occurs in ppl infected w/ HBV. HDV accelerates the progression of chronic HBV.

Can be acquired either simultaneously with HBV as a coinfection or as a superinfection in people who are already chronically infected with HBV.

Question 6

Hepatocellular Carcinoma

Answer 6

The most common type of primary liver cancer. Hepatocellular carcinoma occurs most often in people with chronic liver diseases, such as cirrhosis caused by hepatitis B or hepatitis C infection.

Question 7

Cirrhosis

Answer 7

Cirrhosis is a late stage of scarring (fibrosis) of the liver caused by many forms of liver diseases and conditions, such as hepatitis and chronic alcoholism. Each time your liver is injured — whether by disease, excessive alcohol consumption or another cause — it tries to repair itself.