Shortness of Breath - Johns Flashcards

1
Q

Define asthma.

A

inflammatory disease of airways with significantly reversible narrowing

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2
Q

What is dyspnea?

A

“abnormally uncomfortable awareness of breathing”

Can be related to exertion or not related to exertion

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3
Q

Define chronic bronchitis.

A

chronic productive cough for three months in two successive years

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4
Q

Define emphysema.

A

pathological term in which there is enlargement of airspaces with destruction of bronchiole walls

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5
Q

Define COPD.

A

“disease state characterized by airflow limitation that is not fully reversible. Progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases.”

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6
Q

What is the DDx for dyspnea on exertion?

A
Congestive heart failure
Angina  (anginal equivalent)
Obstructive pulmonary disease
Pleural Effusion
Anemia
Hypothyroid
Metabolic acidosis
Anxiety and hyperventilation
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7
Q

How common is COPD?

A

Fourth-ranked cause of death in U.S.

Most important lung disease in U.S.

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8
Q

What are the clinical features of COPD?

A

-Patients have usually smoked at least 20 cigarettes per day for 20 or more years
-Usually starts with a chronic cough
-Dyspnea may not occur until 10-20 years later
Progesses to:
-Chronic clear sputum production
-Weight loss
-Morning headache
-Hypercapnia with hypoxemia
-Cor pulmonale

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9
Q

What are the physical exam findings in COPD?

A
Prolonged expiration 
Hyperinflation – Increased A-P diameter
Hyperresonent to percussion
Depressed diaphragm
Decreased breath sounds
Wheezes – airflow obstruction
End-stage – accessory muscles, pursed lips, cyanosis, enlarged liver, asterixis
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10
Q

What are the diagnostic tests used to diagnose COPD?

A
Chest x-ray
Chest CT
Pulmonary function tests
          Decreased FEV-1
		Decreased FEV-1/FVC
		Increased total lung capacity
		Absence of bronchodialator response
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11
Q

What is the DDx for COPD?

A
  • COPD
  • Asthma
  • CHF
  • Bronchiectasis
  • Tuberculosis
  • Obliterative bronchitis
  • Diffuse panbronchiolitis
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12
Q

What is the most important component of COPD management?

A

Smoking cessation!!!
Slows decline in FEV-1
5-year decline in smokers – 267 ml
sustained quitters – 72 ml

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13
Q

What is the triad of symptoms for asthma?

A

Persistent wheeze – 35 %
Chronic cough – 24 %
Chronic dyspnea – 29%

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14
Q

What are the physical exam findings in asthma?

A

Widespread, high-pitched wheezes
Wheezes are poor predictor of severity of outflow obstruction however
Signs in severe outflow obstruction
accessory muscles
pulses paradoxus (greater than 10mmHG fall
in systolic pressure during inspiration)

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15
Q

How do you evaluate Peak Expiratory Flow Rates (PFT’s)?

A
Patient measures at home
      “Red” – less than 50% of personal best
      “Yellow” – 50 to 80%
      “Green” – Over 80%
Spirometry – FEV-1 and FVC
Degrees of obstruction  (predicted FEV-1)
     >80% - borderline
     60-80% - mild obstruction
	 40-60% - moderate
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16
Q

What is the DDx when considering asthma?

A

Children – foreign body, cystic fibrosis
Young and middle-aged adults –GERD, PE, bronchiectasis
Older-aged – COPD, heart failure

17
Q

What are the four categories of asthma severity?

A

Mild intermittent
Mild persistent
Moderate persistent
Severe

18
Q

What is the preferred treatment for Step 1 in asthma?

A

short-acting β-agonist

19
Q

What is the preferred treatment for Step 2 in asthma?

A
inhaled corticosteroid
(alternative = leukotriene receptor antagonist)
20
Q

What is the preferred treatment for Step 3 in asthma?

A

Low dose inhaled corticosteroid + long-acting β-agonist
OR
Medium dose inhaled corticosteroid

21
Q

What is the preferred treatment for Step 4 in asthma?

A

Medium dose inhaled corticosteroid + long-acting β-agonist

22
Q

What is the preferred treatment for Step 5 in asthma?

A

High dose inhaled corticosteroid + long-acting β-agonist

23
Q

What is the preferred treatment for Step 6 in asthma?

A

High dose inhaled corticosteroid + long-acting β-agonist + oral corticosteroid
(consider omalizumab for patients with allergies)