Shit to memorize: Chapter 4

Question 1

PGI and NO

Answer 1

: vasodilators impede platelet adhesion

a. Stimulated during coagulation by thrombin and cytokines

Question 2

adenosine diphosphatase

Answer 2

degrades ADP to impede platelet aggregation

Question 3

heparin

Answer 3

act indirectly, cofactors that inhibit thrombin and other coagulation factors by Antithrombin III

Question 4

Thrombomodulin

Answer 4

binds to thrombin and converts it to an anti-coagulant that can activate protein C
a. Protein C inactivates Va and VIIIa

Question 5

TFPI

Answer 5

directly inhibits VIIa and Xa

Question 6

tPA

Answer 6

fibrinolytic

plasminogen to form plasmincleaves fibrin and degrades thrombi

Question 7

vWF

Answer 7

on endothelium

allows for PLTs to bind endothelium

Question 8

TF

Answer 8

activator of extrinsic clotting cascade

activated by TNF and IL1

Question 9

PAI

Answer 9

plasminogen activator inhibitor
limits fibrinolysis
enhances thrombosis