SHEEHAN'S SYNDROME

Question 1

What is Sheehan’s Syndrome?

Answer 1

a loss of large amount of blood or severely low blood pressure during/after childbirth leading to deprivation of oxygen to pituitary, leading to necrosis

Question 2

What are the symptoms of Sheehan’s Syndrome?

Answer 2

Fatigue

Lerthargic

Intolerance to cold

Memorrhagia

Hoarse voice

Myalgia

Weight gain

Constipation

Question 3

What are the signs of Sheehan’s syndrome?

Answer 3

Round puffy face

Bradycardia + low blood pressure

Cold hands

Non-putting oedema

Thin and dry skin

Question 4

What are the blood tests and their results for Sheehan’s Syndrome?

Answer 4

Estradiol, FSH, LH: low

U&E: hyponatramia

Cortisol and ACTH: low

TFT: normal/low TSH and low T3/4

Question 5

Which hormone replacement therapy would you request to treat Sheehan’s Syndrome?

Answer 5

Prednisone (corticosteroids)

Levothyroxine (TSH)

Eostrogen (+ progesterone if uterus is not removed)

GH (lows cholesterol levels)

Question 6

What is Adrenal Crisis?

Answer 6

Life-threatening state where Adrenal cortex produces too little cortisol > causes low blood pressure, low blood glucose levels and hyperkalemia