SG

Question 1

Mrs Claus breaks her hip, DXA scores of Z = -1.7, T = -2.8. Why?

Answer 1

No longer produces estrogen

Question 2

22-yo has migratory polyarthritis. What is assoc.?

Answer 2

HLA-B27

Question 3

40 yo man has weakness and reduced dystrophin. What is the Dx?

Answer 3

Beckers muscular dystrophy

Question 4

A finger displays a flexed PIP & extended DIP. What is the deformity?

Answer 4

Boutonnieres deformity

Question 5

A horn cysts w/ greasy crust, black plaque stuck on to his cheek. What do you suspect?

Answer 5

Neurofibromatosis 1

Question 6

Joints are swollen & warm. PIP & MCP are involved. Contributing pathogen?

Answer 6

Autoantibodies directed against IgG

Question 7

What is assoc. w/ MHC II?

Answer 7

Uveitis

Question 8

A neonate displays a bell shaped thorax & multiple fractures?

Answer 8

Mutation in gene encoding Type I collagen components

Question 9

Osteoma of the mandible w/ polyps. What is the germline mutation?

Answer 9

APC

Familial adenomatous polyposis

Question 10

A soft tissue tumor right above the knee joint w/ swindle cell proliferation?

Answer 10

Synovial sarcoma

Question 11

Malignant soft tissue tumor involving deep soft tissue or retroperitoneum?

Answer 11

well-differentiated liposarcoma

Question 12

Can’t release grip after handshake?

Answer 12

Myotonic dystrophy

Question 13

Radio graphic finding w/ hyperparathyroidism?

Answer 13

Rugger jersey vertebrae (osteoporosis)

Question 14

Needle shaped crystals & negative birefringent?

Answer 14

hyperuricemia

Increased turnover of nucleic acids

Question 15

Thigh mass, unencapsulated w/ areas of hemorrhage & necrosis?

Answer 15

Fibrosarcoma

Question 16

T(11-22) translocation?

Answer 16

Ewing’s sarcoma

Question 17

What strain of HPV is most oncogenic?

Answer 17

16 & 18

Question 18

What are the oncogenic proteins assoc. w/ HPV?

Answer 18

• E6: p53
• E7: RB

Question 19

Clue cells on vaginal screening?

Answer 19

Bacterial vaginosis

Question 20

Rubbing/scratching of the skin to relieve pruritus, epithelium has mitotic activity in the basal & prickle layers?

Answer 20

Lichen simplex chronicus

Question 21

Pruritic red crusted lesions on labia majora, tumor cells w/ halos, PAS+, S-100-. Dx?

Answer 21

Extramammary Pagets Dx

Question 22

S-100+, no mucopolysaccharides, keratin-. Dx?

Answer 22

Malignant melanoma

Question 23

Desmin+?

Answer 23

Embryonal rhabdomyosarcoma

Question 24

Pt has CIN-1, mild dysplasia, koiocytotic atypia, nuclear enlargement, hyperchromasia. What do you recommend?

Answer 24

Regular PAP

Question 25

Pt has invagination into myometrium?

Answer 25

Adenomyosis

Question 26

What is a great risk factor for cancer

PAP smear

Answer 26

Atypical epithelial hyperplasia

Question 27

Cancer in women that increases w/ risk factor of smoking?

Answer 27

Invasive carcinoma of the cervix – squamous cell carcinoma

Question 28

Dx where more than half metastasize to distant organs?

Answer 28

Leiomyosarcoma

Question 29

Pt has GNAS mutation. Dx runs in family (maternal). How does he present?

Answer 29

Short stature

Question 30

Phenotype of a mole (hydatidiform)?

Answer 30

• Complete: empty egg; 46 (diploid)
• Incomplete: viable; 69 (triploid)

Fetal parts can be present in incomplete

Question 31

What type of mole (hydatidiform) can present fetal parts?

Answer 31

Incomplete