Sexual Health Flashcards

1
Q

What is important in terms of Consent and confidentiality for sexual health histories?

A

Confidentiality - If young person does not want parents or guardians involved, doctor should explain the possible benefits of having parents informed, but respect the young person’s wishes, views and confidentiality if they do not wish for parental involvement.

Consent - Young people <16 involved in sexual activity should be questioned to elicit whether sexual activity is voluntary, to ensure there is no coercion (particularly when there is a disparity of age), sexual exploitation, rape, or other sexual abuse.
Where sexual abuse is suspected or disclosed the clinician must work with the young person to support them and address the possible sequelae of STIs, pregnancy, psychological, and psychosexual issues.
The clinician has a duty to disclose the information to child protection services but should seek the young person’s agreement wherever possible.

The law permits the disclosure of confidential information necessary to safeguard a young person. Legal advice should be taken in doubtful cases.
Disclosure against the young person’s wishes is dealt with in the General Medical Council (GMC) guidelines Confidentiality: Protecting and Providing Information, in the British Medical Association (BMA) publication Consent, Rights and Choices in Health Care for Young People, the Children Act, and the Department of Health (DOH) document Medical Responsibilities.

In practice, the clinician must take into account both the need of the young person for a confidential sexual health service and the need to protect that young person from sexual abuse and sexual exploitation. The clinician also has a duty to consider the possibility that other young people may be at risk of abuse.

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2
Q

What are key questions to ask when taking a Sexual health history?

A
  • https://www.bashhguidelines.org/media/1078/sexual-history-taking-guideline-2013-2.pdf

Identify high-risk groups, types of swabs to take, at risk contacts

  • Presenting complaint
  • History of presenting complaint –leave until last
  • Previous medical history (to include surgical, obstetric, gynaecology (smear), sexually transmitted diseases, vaccinations e.g. HEP B)
  • Drugs/allergies
  • Systems review
  • Family history
  • Social history

Presenting complaint
Symptoms - duration, associated features

Male
•	Urinary – dysuria
•	Urethral discharge
•	Testes – pain, swelling
•	Rectal samples – blood, mucus, rectal pain (MSM)
Women
•	Urinary - dysuria
•	Vaginal discharge – colour, smell, amount
•	Bleeding – intermenstrual / postcoital
•	Lower abdominal pain 
•	Dyspareunia – superficial, deep
•	Menstruation
•	Pregnancy? 

Both
• Skin changes i.e. rash, spots, sores, blisters, lumps

‘These are questions we ask everyone who presents with a vaginal discharge. Do you mind if I ask them?’

‘I need to ask you these sensitive questions so that I know where I need to take swabs from’

‘I need to ask questions about your partners so we can decide who else may need treatment

PMH
• Pregnancy/terminations/miscarriages
• Smears
• STIs

DHX
• Contraception
• Allergies

Last sexual contact

• When
• With whom – male/female, regular (duration of relationship) or casual
– Type of sex – oral (oropenile, orovaginal, oroanal), anal (insertive and/or receptive), vaginal, digital contact
– Condom use with each type of sex, ?every time ?any condom accidents
– Sex toys/rimming etc.

Similar details of all sexual partners over previous 3 months – ‘when did you last have sex with some one who was not the person you have just told me about?’

Risk assessment
Have you/has anyone you have had sex with
• Known HIV / positive partner
• IVDU
• MSM
• Sex with someone who was born outside of the UK (Africa, Asia, Eastern Europe due to IVDUs)
• Commercial sex worker (CSW) (have you ever paid for or been paid for sex)

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3
Q

What questions do you ask as part of a HIV risk assessment?

A
  1. Introduce yourself, say you’re a medical student, ask consent
  2. Explain why you’re talking to them
  3. Name, age, occupation, relationship status
  4. Explain confidentiality
  5. Why have they come today?
    - Do they have any symptoms?
    - Why do they think they need a test?
  6. First would like to assess risk factors
    - Have they ever had a partner they know/think is HIV positive? Were condoms used
    - Have they ever had sex with a man or a bisexual man
    - Have they ever had sex with anyone born outside the UK (Caribbean, Africa, south east Asia, Indian subcontinent, Russia) or who has lived in a high risk area
    - Have they had sex outside the UK
    - Have they ever injected drugs or slept with someone who has?
    - Have they ever paid for sex or been paid for sex?
    - Ever had a blood transfusion or medical treatment abroad
  7. How much do they know about HIV/AIDS
    - Difference between the two
    - Incurable but important to detect early
  8. Is it a good idea to get tested?
    - Gives peace of mind if negative
    - If positive can help prolong good health, support, advise about safe sex
    - May be anxious when waiting
    - If you are positive may be anxious and worried about telling people
    - May limit insurance (negative tests don’t affect anything)
  9. What does the test involve?
    - Blood test
    - Result should take 48-72 hours
    - May then ask you to come back in to get the results
    - If they’re high risk get them to come in anyway
  10. Window period
    - May take 3 months before antibodies can be detected
    - If the specific contact worried about was over 3 months ago then only need one test
    - Otherwise will need another test in 3 months time.
  11. Confidentiality; doesn’t go in GP notes
  12. Would they like to have the test?
  13. Offer them a full screen
    - May also be at risk for other infections
    - Blood test to also look for syphilis and Hep B+C
    - Swabs for Chlamydia and Gonorrhoea
  14. Will arrange for it to be done
  15. Give them a leaflet and a follow-up appointment
  16. Thank you
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4
Q

What should you do about Partner notification?

A
  • Arrangements should be in place for the management and treatment of all sexual partners of clients found to have an STI.
  • Clients and partners should abstain from sexual intercourse until treatment has been completed. Contact tracing of perpetrators is a complex issue which should be addressed if possible with the help of a Health Advisor who can arrange provider referral if appropriate.
  • This will require discussion with the client about our duty of care towards the client, the assailant and respective partners/sexual contacts.
  • Contact tracing can be arranged via the investigating police officer bearing in mind that positive STI may have evidential potential and will require demonstrating a chain of evidence.
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5
Q

What should you do when you are made aware of Sexual assault?

A

Follow up after sexual assault –

  • Offer first HIV PEPSE follow-up appointment before starter pack finishes (usually 3-5 days) and carry out baseline bloods if not already done, review the wish to continue, side effects and compliance followed by weekly (if problems) or two weekly (if no problems) follow up appointments until completion of the course (41, 52)
  • Offer STI screening at baseline and/or 2 weeks after the alleged assault.
  • Do baseline bloods for syphilis, hepatitis B and C depending on risk assessment at first follow up appointment
  • Offer hepatitis B vaccination within 6 weeks of assault (45, 57, 58, 59) and complete within the timeframe dictated by chosen schedule
  • Carry out risk identification (child protection, self-harm, domestic violence)
  • Carry out pregnancy testing where and when applicable Review psychosocial needs and coping 22
  • Use of 4th generation HIV tests (for both HIV antibodies and p24 antigen) is recommended
  • Offer HIV test at 3 months post assault (or 3 months post completion of HIV PEPSE if given)
  • Consider HIV test 1 months post high-risk exposure if 4th generation HIV tests are used (60) Offer serological tests for hepatitis B, C and syphilis at 3 months post assault.
  • Consider repeating tests at 6 months for Hepatitis B and HIV as late seroconversion has been documented

Pregnancy prevention –

  • Copper intrauterine contraceptive device (CuIUD)
  • Hormonal emergency contraception

Pregnancy following sexual assault -
If a pregnancy test is positive, discuss options which include:
- Continuing with the pregnancy
- Termination of pregnancy
- Paternity testing
- Using products of conception as evidence

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6
Q

What is Genital discharge?

A

Excessive vaginal discharge can be physiological or pathological
Defined as any one of the three presentations-
• Excessive vaginal discharge not associated with menstruation; pre, mid and post period.
• Offensive or malodorous discharge
• Yellowish or mucopurulent discharge

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7
Q

What are the causes of Genital discharge?

A
CAUSES- 
•	Physiological – 1-4mls per 24hrs, white/clear, non-offensive odour, varies with menstrual cycle
o	Age dependent
	Neonate and infant 
	Pre puberty 
	Child bearing
	Post-menopausal 
o	Excessive secretion
	Pregnancy or sexual arousal 
•	Pathological - 
o	Non infective:
	Chemical irritation 
•	Antiseptics, bath additives, perfume soaps
	Foreign bodies
•	Retained tampons
	Cervical ectopy
o	Infective: causes cervicitis 
	Non-STI (vaginal): bacterial vaginosis, candida
	STI:
•	Trichomonas vaginalis (vaginal)
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8
Q

What question do you needs to ask when taking a Hx of Genital discharge?

A

HISTORY -
• Source of discharge must be determined- Perineal discharge could originate from vagina, cervix, urinary tract and rectum
• Ascertain the following attributes of the discharge: quantity, duration, colour, consistency and odour
• Symptoms include
o itching or burning . External Dysuria, Dyspareunia
• Prior similar episodes
o Sexually transmitted infection
o Sexual activities
o Birth control method
o Last menstrual period (ALWAYS assess pregnancy risk before treating)
o Douching practice and other RFs
o Antibiotic use
o General medical history
Systemic symptoms such as lower abdominal pain, fever, chills, nausea, and vomiting

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9
Q

What is the treatment for Genital discharge?

A

Treatment of individual causes: (REST are below)
• Eczema / psoriasis- moderately potent topical steroid e.g. Betnovate cream
• Lichen planus- usually self-limiting
• Lichen sclerosis- potent topical steroid. Requires long term follow up as small risk of malignant transformation.
• Scabies/pubic lice- Topical Permethrin and treat all household/sexual contacts
*Arrange urgent admission for women with pelvic inflammatory disease (PID) who are pregnant, pyrexial and unwell, or unable to take oral fluids or medications.

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10
Q

What are the causes of Bacterial vaginosis?

A

o Commonest cause of abnormal discharge in women of child-bearing age
o In healthy vagina, lactobacilli dominant + low levels of other bacteria = pH <4.5
o In Bacterial vaginosis, pH >4.5-6.0 as flora dominated by anaerobic bacteria (lactobacilli may be present)

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11
Q

What are the Risk Factors of Bacterial vaginosis?

A

vaginal douching, black, smoker, receptive cunnilingus, recent change of sexual partner, presence of STI

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12
Q

What are the clinical features of Bacterial vaginosis?

A
  • 50% asymptomatic):
    o Offensive fishy smelling vaginal discharge
    o Increased volume, thin, watery, white
    o Not assoc. with soreness, itching, irritation or signs of inflammation
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13
Q

What are the investigations for Bacterial vaginosis?

A
  • Outpatient/GP: typical Sx, pH >4.5, low vaginal swab to lab
  • GU: low vaginal swab, Hay/Ison criteria Gram stained vaginal smear
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14
Q

What is the treatment for Bacterial vaginosis?

A
  • General advice: avoid vaginal douching and antiseptic agents/bath products
  • Treatment: PO/topical metronidazole – Sx women, undergoing certain surgeries, pt. choice (if lactating = topical); no Rx of sexual partner needed
    o Oral = metronidazole 500mg BD 7 days OR clindamycin 300mg BD 7 days
    o Topical = 0.75% metronidazole gel 5 days OR clindamycin cream 2% 7 days
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15
Q

What are the complications of Bacterial vaginosis?

A

↑incidence in PID, cellulitis/abscess following TV hysetercomy, late miscarriage, preterm birth, PRoM and post-partum endometritis

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16
Q

What are the causes of Candida?

A
  • Candida albicans 90-92%

- Non-albicans species – e.g. C. glabrata/topicalis/krusei etc (poor Rx response )

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17
Q

What are the Risk Factors of Candida?

A

immunosuppression (inc. pregnancy, diabetes), Abx use, elevated oestrogen

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18
Q

What are the clinical features of Candida?

A

o Vulval itch, soreness
o Erythema, oedema, fissuring and excoriations
o Satellite lesions
o Thick vaginal discharge
o Superficial dyspareunia and external dysuria
o 10-20% of women in reproductive years colonized but asymptomatic = no Rx required

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19
Q

What are the investigations for Candida?

A
  • NOT usually done – Rx based on Sx
    o If no response to Rx/doubt over diagnosis = microscopy of gram-stained vaginal slide and culture of low vaginal swab asking for yeast sensitivities
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20
Q

What is the treatment for Candida?

A
  • General advice: routine use of soap substitute + regular emollient, avoid tight fitting synthetic clothes + local irritiants
  • Treatment: clotrimazole pessary 500mg stat OR fluconazole 150mg PO stat (oral C/I in pregnancy = 7 days of topical azole) – depends on preference/availability; no need to Rx asymptomatic male partners (consider asking re/ contraception)
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21
Q

What is Dysuria?

A

Painful or difficult urination, due to irritation to bladder or urethra

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22
Q

What are the causes of Dysuria?

A

Stones, infection, indwelling catheter

May suggest a UTI

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23
Q

What are the clinical features of Dysuria?

A

Burning sensation when urinating

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24
Q

What is the treatment for Dysuria?

A

Treatment of dysuria depends on its cause:
o Cystitis and pyelonephritis — These infections, usually caused by bacteria, can be cured with antibiotics taken by mouth. Antibiotics may be given into a vein (intravenously) for severe pyelonephritis with high fever, shaking chills and vomiting.
o Urethritis — Urethritis is treated with antibiotics. The type of antibiotic used depends on which infection causes the urethritis.
o Vaginitis — Trichomoniasis and bacterial vaginosis are treated with antibiotics. Yeast infections are treated with antifungal drugs, either as a pill by mouth or as a suppository or cream inserted into the vagina.
If you are sexually active and are being treated for dysuria caused by a sexually transmitted disease, your sex partners must be treated, too.

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25
Q

What are the causes of Trichomoniasis Vaginalis?

A
Ulcers usually caused by sexually transmitted diseases such as genital herpes, syphilis, chancroid, or Chlamydia trachomatis. 
Non sexual causes – 
•	Fungal – vulvovaginal candidiasis 
o	burning during sex and urination
o	itching
o	increased vaginal discharge
•	Viral, bacterial infections 
•	Inflammatory disease  - Crohns disease
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26
Q

What are the clinical features of Trichomoniasis Vaginalis?

A
•	Sometimes with enlarged groin lymph nodes
•	Painful 
o	Chancroid 
o	Genital herpes simplex
•	Painless
o	Syphilis
o	Lymphogranuloma venereurm 
o	Granuloma inguinale
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27
Q

What is the treatment for Trichomoniasis Vaginalis?

A

• STIs are typically treated with antibiotic and antivirals – acyclovir
• Non infection caused –
o corticosteroids
o antihistamines
o immunomodulatory drugs, such as methotrexate

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28
Q

What are the causes of Trichomoniasis Vaginalis?

A

• Infection found in vagina, urethra and paraurethral glands of female
• Trichomonas vaginalis – flagellated, anaerobic protozoan
o Motile flagellate protozoa seen.
• WBC often present

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29
Q

What are the clinical features of Trichomoniasis Vaginalis?

A

• 10-15% asymptomatic – especially in men
• Profuse, offensive, greenish/grey, frothy discharge
• Vaginal and vulval irritation/itch
• Superficial dyspareunia
• Dysuria
EXAMINATION:
• Pelvic:
• Inspection:
• Vaginal discharge and vulval erythema (vulvitis and vaginitis)
• 2% strawberry cervix
• Cusco speculum:
• Cervicitis
• Erythematous, punctuate appearance of a cervix (strawberry cervix/colpitis macularis)

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30
Q

What are the investigations for Trichomoniasis Vaginalis?

A
  • Diagnostic:
  • Vaginal pH >5.0
  • HVS for direct microscopy and culture in a Trichomonas medium = vulvovaginal NAAT
  • Swab from posterior fornix at speculum exam for wet mount microscopy = trichomonads seen (pathognomonic)
  • STI screen:
  • HVS (BV, Candida albicans)
  • Endocervical swab (Neisseria gonorrhoea, Chlamydia trachomatis)
  • Blood tests for HIV, syphillis and hepatitis B (abundance of leukocytes)
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31
Q

What is the treatment for Trichomoniasis Vaginalis?

A
  • Advice:
  • Contact tracing, treat contacts at same time, contraception advice: avoid sex for 1wk and until partners completed Rx
  • Medical:
  • Metronidazole (2g PO stat dose OR 400mg BD 5-7 days – option for male contacts) OR Tinidazole 2g orally single dose Met usually cures 90% of ppl after first dose
  • Repeat swab 7 days after completing treatment
  • Follow-up examination after 2 m.
  • Rx failure consider compliance, exclude vomiting of metronidazole, sexual Hx ?reinfection, resistance
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32
Q

What are the Risk Factors of Trichomoniasis Vaginalis?

A

Sexual contact (almost exclusively)

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33
Q

What are the complications of Trichomoniasis Vaginalis?

A
  • PID (ascending infection)
  • Premature delivery, PROM, low birth weight in pregnancy
  • SEs of Tx (flushing, headache, nausea, etc)
34
Q

What are the causes of Chlamydia trachomtis bacteria?

A
  • Obligate intracellular bacterium
  • Most commonly reported curable STI in UK
  • Highest prevalence is in <25yrs
  • High frequency of transmission, 75% of partners also infected
  • Majority of infections asymptomatic
  • Also cause of urogenital infection and lymphogranuloma venerum (LGV) in men urethral discharge typically clear/white; rectal Sx should always be Ix for LGV
    a. 3 site screening for MSM
35
Q

What are the Risk Factors of Chlamydia trachomtis bacteria?

A
  • <25 years (70% of infections)
  • New sexual partner
  • > 1 partner in last year
  • Lack of consistent condom use
36
Q

What are the clinical features of Chlamydia trachomtis bacteria?

A

• Can present with acute infection, acute or chronic PID (see PID)
• Acute infection:
• Asymptomatic in ~60-80%
• Vulval irritation
• Superficial dyspareunia/deep dyspareunia
• Dysuria and frequency
• ↑Vaginal discharge – clear/white
• PCB, IMB
• Vague lower abdominal pain
• Fever
Male – urethrtisis dysuria and urethral discharge, unilateral testicular pain - epididymo-orchitis
• Acute infection:
• Pelvic Inspection:
• Copious mucous vaginal discharge, pain, induration
• Speculum:
• Mucupurulent cervicitis, friable + contact bleeding
• Men: mucoid/purulent discharge, perineal fullness
• PID – adnexal tenderness and cervical motion tenderness, abdominal tenderness

37
Q

What are the investigations for Chlamydia trachomtis bacteria?

A

Intracellular gram -ve bacterium which has viral and bacterial characteristics.

38
Q

What is the investigations for Chlamydia trachomtis bacteria In females?

A

Window period: test at 2wks – consider repeat test based on sexual Hx
• Acute Infection:
• (Endocervical swab – culture and sensitivity)
• Vulvo vaginal swab (NAATs, red)
• HVS (TV, BV, Candida, gonorrhoea)
• Blood sample (HIV, syphillis, hepatitis B)
• Urine dip and MSU
• Women with rectal Sx = refer to GUM
• Acute PID: FBC (WCC), ESR, CRP, U&Es
• Chronic PID: laparoscopy, hysterosalpingogram, dye test (tubal patency)

39
Q

What is the investigations for Chlamydia trachomtis bacteria In males?

A
  • First void urine (NAATs)
  • Swab urethra from discharge (CT and GN)  gram stained urethral/rectal smear for microscopy
  • Blood sample (HIV, syphillis, hepatitis B)
  • MSU if UTI
40
Q

What is the treatment for Chlamydia trachomtis bacteria?

A

• Acute infection:
• 1g azithromycin stat
• Doxycycline 100mg BD 1 wk – C/I in pregnancy
• Erythromycin for 1 wk if systemic infection
• Advice:
o Avoid intercourse for 7 days after completion treatment and partner completion of Rx. Contact tracing. PID
• Test of cure not routine but recommended in pregnancy
 Should not be performed earlier than 3wks after Rx completion
 Repeat testing at 3-6mths after Rx in under 25s
 Non-viable DNA picked up for 3-5 weeks following treatment
Males: Offer Rx on the day – as for females Epididymo-orchitis requires extended Rx

41
Q

What are the complications of Chlamydia trachomtis bacteria?

A
  • PID, endometritis, salpingitis
  • Tubal infertility
  • Ectopic pregnancy
  • Sexually acquired reactive arthritis (SARA)
  • Perihepatitis (Fitz-Hugh Curtis syndrome)
42
Q

What are the causes of Gonorrhoea?

A
  • Sexual intercourse with infected partner.
  • 75% transmission rate
  • Neisseria Gonorhoea gram –ve diplococcus
  • Primary sites of infection – urethra, endocervix, rectum, pharynx, conjunctiva (3 site screen for MSM)
  • Mucus membrane transmission by direct inoculation of infected secretions
  • Can cause pelvic inflammatory disease
43
Q

What are the clinical features of Gonorrhoea in females?

A
  • Asymptomatic in 50% women
  • Incubation period 2-10days.
  • Classic early symptoms
  • Urethritis: severe dysuria (worse at start) – not frequency
  • Cervicitis: ↑purulent, offensive vaginal discharge
  • Deep dyspareunia
  • IMB, PCB, menorrhagia
  • Lower abdo pain (25%)
44
Q

What are the clinical features of Gonorrhoea in males?

A
  • Symptomatic in 90% men
  • Urethritis (80%) – yellow discharge, dysuria
  • Epididymal tenderness or swelling
  • Balanitis – inflammation of glans
  • Rarer: Infection of rectum (discharge, discomfort, tenesmus) or pharynx (usually asymptomatic
45
Q

What are the complications of Gonorrhoea in females?

A
  • Complications:
  • Local spread: bartholinitis (bartholin’s glands), skenitis (Skene’s gland)
  • Ascending spread: salpingitis- fever, malaise, lower abdominal pain (10-20%)
  • Disseminated: septicaemia, arthritis, endocarditis - fever, malaise, rash, tenosynovitis (5%)
  • Rarer:
  • Infection of rectum (discharge, discomfort, tenesmus) or pharynx (usually asymptomatic)
  • Perihepatitis (Fitz Hugh-Curtis)- RUQ pain, worse on coughing
46
Q

What are the complications of Gonorrhoea in males?

A

• Complications: epididymo-orchitis, proctitis, disseminated gonorrhoea

47
Q

What are the examination findings for Gonorrhoea?

A
  • General (if ascending spread or disseminated):
  • Pyrexia >39’C, Tachycardia, Dehydration, Joint tenderness & swelling, distal purple macular rash.
  • Suspect disseminated gonococcal infection in any young person presenting with tenosynovitis and fever.
  • Abdomen:
  • Lower, abdominal tenderness and peritonism
  • Pelvic:
  • White/ yellow/ green purulent discharge
  • Abscess (urethral or Bartholin’s)
  • Speculum:
  • Acute cervicitis with mucopurulent discharge, endocervical contact bleeding
  • Bimanual:
  • Uterine tenderness, Adnexal tenderness, Cervical excitiation = PID
48
Q

What is the pathology of Gonorrhoea?

A
  • Intracellular aerobic Gram –ve kidney shaped diplococci seen in pairs (facing each other)
  • Infects the columnar and transitional epithelium of GU tract
  • Diagnosis is based on a Gram stain of appropriate swab (50% sensitivity) followed by culture on Thayer-Martin medium and chocolate agar.
  • 20% will have detectable infection at multiple sites. (pharynx, rectum)
49
Q

What are the investigations for Gonorrhoea?

A
  • Urine: beta-hCG (exclude pregnancy), MSU (exclude UTI)
  • STI screen - chlamydia, BV, TV, candida, syphillis, HIV, hepatitis
  • Gonorrhoea
  • Endocervical swab: (gonorrhea culture) – always
  • Vulvo vaginal swab (NAATs)
  • Microscopy and culture of gram-stained swab will identify N. gonorrhoea and antibiotic sensitivity (usually sensitive to penicillin) – from HVS
  • Bloods: FBC (WCC), ESR, Blood culture.
  • Man – gram-stained urethral and rectal smear demonstrating gram –ve intracellular diplococci under microscope
  • NAAT from site of infection
  • Gonorrhowa culture from site of infection (ONLY if Sx)
  • Urethral, Rectal, Pharyngeal swabs – MSM
50
Q

What is the treatment for Gonorrhoea?

A

• Advice: avoid sex for 1wk of Rx completion (+ Rx of partner!), contact tracing
• TOC for all at 2wks after therapy
• Admit if disseminated disease
• Ceftriaxone 500mg IM + azithromycin 1g PO (Chlamydia co-infection)
• Return for re swab 3 days after completing treatment
NB. Consider treatment for chlamydia – co-exist often

51
Q

What is Herpes Simplex Virus?

A

STI caused by HSV 1 and HSV 2 – infection may be primary/non-primary (disease episode initial or recurrent, and symptomatic or asymptomatic)

52
Q

What are the causes of Herpes Simplex Virus?

A

Enter host through mucocutaneous surfaces, following infection can be latent and then be reactivated.
In primary HSV (infection in those that have never been infected with HSV) causative organism equally likely to be HSV1 or HSV2

53
Q

What are the clinical features of Herpes Simplex Virus?

A

• Short latent period – 7days ish
• Primary infection (worse) – Asymptomatic, extensive SORE genital ulceration with local regional lymphadenopathy and systemic ‘flu-like’ symptoms, external dysuria, discharge, neuropathic pain in buttocks/genitals
o Local – painful ulceration, dysuria, vaginal or urethral discharge
 Male – Inflammation, erythema, pain, superficial well-defined ulcer
 Female – multiple areas of superficial, poorly defined ulcers (due to skin folds): ‘kissing’ ulcer due to auto-inoculation
o Systemic – fever, myalgia
• May last 4 wks if not treated
• Lesions – vesicles that burst leaving superficial tender ulcer with erythematous halo and greyish white exudate
• Recurrent infections shorter and less severe than primary infections, lasting 3-5 days. Virus lives in dorsal route ganglion following primary infection (latent) → periodically reactivates to cause symptomatic unilateral lesions or asymptomatic, but infectious, virus shedding
• Reactivation – trauma, menstruation, stress
• HSV 2 reactivate more than HSV 1 (4-6x per annum compared to once per annum)
• Prodromal neuralgia pain down leg, buttocks common
• Most infectious during symptoms/shedding

54
Q

What are the investigations for Herpes Simplex Virus?

A
  • Clinical diagnosis – ask about past Hx to know if primary/non-primary
  • DIAGNOSIS – swab ulcer vesicular fluid for viral PCR (HSV and syphilis) – confirms whether 1 of 2 (could be either; while core sore is only 1)
  • STI screen – NAATs urine, bloods HIV and HEP B and syphilis
  • Typing HSV strain allows more informed discussion at primary infection
55
Q

What is the treatment for Herpes Simplex Virus?

A

Primary episodes
• Acyclovir 400mg PO TDS for 5 days
• Topical/oral analgesia
Recurrent episodes (not immune once infected)
• Self limiting, rarely need treatment
• Advise – saline baths, analgesia
• Frequent episodes – episodic antiviral treatment, initiaited in first 24-48 hr attack

After 1st episode frequency recurrent episode decreases year on year. Infectiveness greatest during symptomatic episode, although can be transmitted with asymptomatic.
NB. Condom use has limited efficacy in preventing HSV transmission.

56
Q

What is the Genital Warts (HPV)?

A

Benign growths of the vulva, cervix, or vagina by infection with HPV

57
Q

What are the causes of Genital Warts (HPV)?

A

Sexually transmitted HPV - primarily subtypes 6 &11 (90%), occasionally 16 & 18 - - associated with malignant potential)
• V. common – most do not result in visible genital tract lesions declining due to HPV vaccine
• Most resolve spontaneously within a year

58
Q

What are the Risk Factors of Genital Warts (HPV)?

A
  • Multiple sexual partners. Partner with previous multiple sexual partners
  • Florid lesions: DM, pregnancy, OCP, immunosuppression, smoking
  • Lifetime risk of HPV is 50% - 1-2% get symptoms
59
Q

What are the clinical features of Genital Warts (HPV)?

A

• Incubation can be 3-8mths (Variable)
• Asymptomatic (most cases)
• Pink papular lesions. Single or multiple. May become cauliflower, keratotic or plaques
• Women - Vulval lesions (painless, slow growing), vaginal introitus, labia, clitoris, perineal, peri anal areas
• Pruritus, burning, tenderness, bleeding (site of lesion)
• Superficial dyspareunia (vaginal warts)
Men – frenulum, coronal sulcus, inner aspect prepuce, penile shaft, perianal area
Inspection:
• Frequently multiple raised papillomatous/ flat lesions of the vulva, vagina and cervix/ clinically undetectable.
• Palpation – hard to touch, irregular

60
Q

What is the pathology of Genital Warts (HPV)?

A
  • HPV gains entry via microabrasions
  • Papillomatous, flat, spiked or inverted lesions
  • Papillomatous lesions:
  • Raised lesion, finger like projections, often contain capillaries
  • Flat lesions:
  • Clinically undetectable, granular surface, mosaic patterns (on colposcopy)
  • Spiked lesions:
  • Hyperkeratotic lesions, with surface projections and capillary tips
  • Inverted lesions: (rare) found on cervix, grow into cervical glands.
61
Q

What are the investigations for Genital Warts (HPV)?

A
  • Clinical diagnosis
  • Biopsy (atypical lesion)
  • Cervical smear + cytology (if last smear > 3y before)
  • Colposcopy + Biopsy (cervical lesions)
  • STI screen
62
Q

What is the treatment for Genital Warts (HPV)?

A

depends on examination + pt. preference (no Rx is an option)
• “Ablative” therapies
• Cryotherapy: < 6 warts and keratinised warts
• Podophyllotoxin cream/solution: soft warts, > 6 warts
• Electrocautery: intrameatal warts
• Immune modulation
• Imiquimod 5% cream: keratinised warts, persistent or recurrent warts
• Lower recurrence rate (30%)
• Surgical
• Curettage
• Excision
• Debulking
• Advice
• Advise barrier contraception (during Tx + further 3m + with new partners)
• Advise to have cervical smears
• Trace and eliminate sexual contacts. Barrier contraception only reduces risk, does not prevent transmission
• Pregnant women:
• Cannot use podophyllin, use alternative Tx, consider LSCS only if large vaginal/ introitus lesions present.

63
Q

What is Molluscum contagiosium?

A
  • Lesions are usually characteristic, presenting as well-defined smooth-surfaced, firm, dome-shaped papules with pearly edges and central umbilication
  • Larger than genital warts
  • Sexual transmission usually affecting young adults. Affects genitals, pubic region, lower abdomen, upper thighs, and/or buttocks
  • Diagnosis is clinical, on the basis of recognising the characteristic lesions
  • Genital molluscum - offer a routine STI screen*
  • No treatment often recommended – goes away within 6wks
  • Could be due to reduced immunity – v. imp not to miss HIV
64
Q

What are the causes of Syphilis?

A

Caused by Treponema pallidum (sphirocete) – predominates MSM aged 25-34, 40% of whom are HIV-1 co-infected (ulcers increase chance of HIV transmission)

65
Q

What are the clinical features of Syphilis?

A

May present in primary stage (9-90 days), secondary stage (6 wks – 6 months), tertiary stage (10-40yrs, gammatous lesions, neurosyphilis, cardiovascular syphilis), or latent stage on screening at GUM/antenatal clinic etc
Usually only infective during first 2 yrs infection (primary, secondary)

66
Q

What are the stages of Syphilis?

A

Primary stage:
• Incubation usually 21 days (range 9-90) – makes it difficult to control
• Chancre - at site inoculation (anogenital), single, small painless ulcer, indurated with clean base; non-purulent serous exudate (can be multiple, painful)
• Homosexual men – anal margin, tonsils, lips, nipples
• Rubbery regional lymphadenopathy – painless
• Resolves over 3-8 weeks
Secondary stage:
• 4-10wks after initial chancre (if primary untreated, 25% develop secondary)
• Multisystem:
o Widespread maculopapular rash on mucocutaneous membranes (e.g. mouth ulcers) + palms + soles; may be itchy
o Condylomata lata (highly infectious, mainly affecting perineum and anus)
o Hepatitis (syphilis can present as isolated raised ALT), splenomegaly, glomerulonephritis
o Generalised lymphadenopathy
o Syphilis balanitis (satellite balanitis)
o Systemic symptoms – headaches, malaise, fever
o Neurological complications
 Acute meningitis
 CN palsies
 Uveitis
 Optic neuropathy
 Interstitial keratitis and retinal involvement
 Patchy alopecia
Latent stage
• Positive blood test but no symptoms
• Early latent <2yrs, late latent >2yrs (see picture to the right)
Tertiary stage (late)
• Neurosyphillis – dorsal column loss, dementia, meningeal involvement, general paresis
• Cardiovascular syphilis – aortitis =AR (aortic regurg) & AAA & angina
• Gummatous – locally destructive fibrous nodules

67
Q

What are the investigations for Syphilis?

A
  • Dark ground microscopy – Treponema pallidum. Taken from ulcer exudate, samples from open skin lesion, sterile aspiration lymph nodes.
  • Serology – primary disease 70-80% +ve, secondary 100% +ve. Repeat serology at 3 months in –ve pts with genital ulceration.
  • Syphilis PCR from ulcer
  • Treponema-specific ELISA method detecting IgG with T.pallidum particle agglutination (TPPA) test. IgM assays also available.
  • STI screen – especially HIV
68
Q

What is the treatment for Syphilis?

A

refer to sexual health)
Primary, secondary, early latent
• Benzathine penicillin 2.4MU IM single dose
• Azithromycin 2g PO
Late latent, CV and gummatous syphilis = benzathine penicillin 2.4MU IM weekly for 3wks (3 doses)
Neurosyphillis (longer Rx – also for ophthalmic syphilis)
• Procaine benzylpenicillin 750mg IM for 10 days or Doxycycline 100mg BD for 2 wks
Penicillin allergic pt – consider penicillin desensitization or doxycycline/erythromycin
RPR/VDRL serial measurements performed at 1, 3, 6, 12 months post treatment (expect fall >2L by 6 months)
Advise: Partner notification, contact tracing

69
Q

What is Balanoposthitis?

A
  • Balanitis = inflammation of glans penis (pic to right is candida balanitis)
  • Posthitis = inflammation of prepuce (= foreskin_
70
Q

What are the causes of Balanoposthitis?

A

– always ask about Hx of eczema/psoriasis or use of irritants

  • Candida
  • Anaerobic balanitis
  • Lichen sclerosus
  • Zoon’s (plasma cell) balanitis
  • Psoriasis
  • Circinate balanitis
  • Irritiant/allergic
  • Fixed drug eruptions
  • Premalignant conditions
71
Q

What are the clinical features of Balanoposthitis?

A
  • Local rash
  • Soreness
  • Itch
  • Odour
  • Inability to retract foreskin
  • Discharge from glans/behind foreskin (different from urethral discharge from urethritis – examine properly)
72
Q

What are the investigations for Balanoposthitis?

A
  • Swab for candida/bacterial culture
  • HSV/syphilis PCR (if skin broken/ulcerated)
  • STI screen – first catch urine chlamydia/gonorrhoea NAAT, pharyngeal and rectal NAAT, bloods – syphilis and HIV
  • Biopsy if cause remains uncertain
73
Q

What is the treatment for Balanoposthitis?

A
  • General advice – avoid soaps/irritants, emollients as soap substitutes, avoid tight fitting underwear, safe sex counselling, orodom (oral sex = anaerobic balanitis)
  • Specific Rx depends on underlying causes: if Candida: topical antifungal (e.g. clotrimazole 1% BD until resolves), can give metronidazole if really convinced it is anaerobic balanitis
74
Q

What is Vulval eczema/vulval lichen sclerosis?

A

Vulval conditions – always ask about Hx of eczema/psoriasis or use of irritiants
= autoimmune inflammatory process
- Can lead to atrophic vaginitis
- Lichen sclerosis – skin discolouration

75
Q

What are the causes of Vulval eczema/vulval lichen sclerosis?

A
  • Candida vulvitis
  • Vulval lichen sclerosus/planus/simplex
  • Vulval psoriasis/eczema
  • Vulval intraepithelial neoplasia
76
Q

What are the clinical features of Vulval eczema/vulval lichen sclerosis?

A
  • Itch/irritation
  • Soreness
  • Dyspareunia
  • Urinary Sx
77
Q

What are the investigations for Vulval eczema/vulval lichen sclerosis?

A
  • Swab for candida/bacterial culture
  • HSV/syphilis PCR
  • STI screen
  • Biopsy if cause remains uncertain
78
Q

What is the treatment for Vulval eczema/vulval lichen sclerosis?

A
  • General advice – avoid soaps/irritants, emollients as soap substitutes, avoid tight fitting underwear, safe sex
  • Specific Rx depends on underlying causes
79
Q

What are the causes of HIV?

A

HIV is a retrovirus

80
Q

What are the clinical features of HIV?

A

• Tends to occur 2-6weeks after exposure
• Only 60% of people will get these symptoms
• Glandular fever like - Get sore throat, fever, lymphadenopathy, malaise and lethargy, arthralgia/myalgia, rash – macropapular often on trunk, ulcers around mouth and penis, headache, meningism, diarrhoea, if CD4 plummets can get oral candidasis and shingles
• Differentials including flu, UTRI, secondary syphilis, but mainly glandular fever. So if glandular fever is suspected always do a HIV test to rule out this differential.
• Primary HIV and early syphilis often co exists
Symptomatic Presentations
• There are a select group of diseases which are clinical indicators that there is a HIV infection. So can present with any one of these
• Most of these conditions are common in the general population.
• Think of HIV if presentation is:
• atypical
• recurrent problem
• severe

81
Q

What are the investigations for HIV?

A
  • Blood test – 2 weeks for results
  • All health care workers should be able to consent for a do a HIV test
  • The test is usually a combined antigen antibody test to look for both
  • P-24 antigen takes 2-4 weeks to develop
  • Antibody takes 4-8 weeks to develop. IgM or IgG
  • There is a window period of 3 months which means that it can take up to 3 months for a positive result to show up but usually shows sooner.
  • There is a rapid point of care test that takes 15-40mins to get a results:
  • If positive result we will do another test to make sure it’s not a false positive
  • Measure viral load – more useful when taking HAART
  • Screen for other STIs

Explaining testing
• We test by firstly explaining the rationale behind it – if no HIV related condition say you live in Leeds which is a high prevalence area 2/1000. Explain that we do a HIV antigen/antibody test and you could come back 3 months later to make sure 100%. If test is positive we will refer you immediately to a specialist service. Need to obtain consent and give written information
• Say that treatment of HIV is very effective and most people can expect to live a normal life expectancy
• Can affect insurance if positive, as can other medical conditions such as diabetes. Negative tests wont affect insurance
• Confidential result

82
Q

What is the treatment for HIV?

A
  • NNRTIs (non-nucleotide reverse transciptase inhibitors) = entry inhibitors – CCR5 receptor antagonists. Stop virus from attaching to cell surface so it can’t enter. Also stop the reverse transcriptase so viral RNA cant change into DNA
  • NtRTI/NRTI (nucleotide/nucleoside reverse transciptase inhibitors)= integrase inhibitors. Stop HIV’s DNA from being intergrated into cells DNA
  • Protease inhibitors - they block new HIV molecules from being cut into a specific shape, this stops them from being infectious.
  • Fusion inhibitors
  • HAART (highly active antiretroviral therapy) is a triple combination of these. 3 of these classes of drug
  • Atripla pill and eviplera pill are 3 of these classes into one drug