Sexual Dysfunction Flashcards
1
Q
What is the pathophysiology of Erectile dysfunction (ED)?
A
A reduction of blood flow to the penis due to:
- hypertension or
- atherosclerosis or
- neuropathies from DM or
- drug use (SSRI/SNRI) or
- spinal cord injury or
- stroke
2
Q
What are some natural products which can help treat Erectile dysfunction (ED)?
A
- Yohimbe
- L-arginine
- Panax ginseng
3
Q
What is the first line treatment for Erectile dysfunction (ED)?
A
PDE-5 Inhibitors
4
Q
What are the 4 PDE-5 Inhibitors?
A
- Sildenafil (Viagra)
- Vardenafil (Levitra)
- Tadalafil (Cialis)
- Avanafil (Stendra)
5
Q
Which PDE-5 Inhibitor can also be used for BPH and at what dose?
A
Tadalafil (Cialis) 5 mg once daily
6
Q
Which PDE-5 Inhibitor can also be used for Pulmonary arterial hypertension (PAH)?
A
- Sildenafil (Viagra)
- Tadalafil (Cialis)
7
Q
What is the typical doings for PDE-5 Inhibitor?
A
- Vardenafil (Levitra) = 10mg
- Tadalafil (Cialis) = 10mg
- Sildenafil (Viagra) = 50mg
- Avanafil (Stendra) = 100mg
8
Q
What circumstancing would require a dose decrease of PDE-5 Inhibitors?
By what % should the doses be decreased by?
A
- ≥ 65 years old
- Using an alpha-blocker
- Using a CYP3A4 inhibitor
- Severe renal or liver disease
Decrease by 50%
9
Q
When using PDE-5 Inhibitors, at what time should patient take doses?
A
- Sildenafil (Viagra) = 1 hours before
- Vardenafil (Levitra) = 1 hour before
- Tadalafil (Cialis) = 30 minutes before
- Avanafil (Stendra) = 15 minutes before
