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Biomo tercer parcial > Sexta hoja > Flashcards

Sexta hoja Flashcards

1
Q

Estrategia terapeutica indicada en pacientes con esclerosis tuberosa en base a la función de las proteínas TSCs

A

Inhibir la vía mTOR, disminuyendo la Rheb activa

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2
Q

Fosforila a TSCs para activar autofagia

A

AMPK

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3
Q

Inhibe la autofagia

A

BCL2

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4
Q

Produce el segundo mensajero fosfatidilinositol 3,4,5 trifosfato

A

Kinasa PI3K

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5
Q

Antagoniza los efectos de PI3K

A

Proteína PTEN

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6
Q

Ocasiona el síndrome de proteus

A

Mutación activadora de Akt

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7
Q

Los receptores RTK se autofosforilan en tirosinas ¿Cuál es el efecto de esto?

A

Activar la vía Akt-mTOR a través de la PI3Kinasa

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8
Q

Usada en asma para tratar la desensibilización de receptor beta adrenérgico, con agonistas de receptor

A

Endocitosis mediada por beta arrestina

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9
Q

¿Para qué interacciona Beta arrestina con la vía MAPK?

A

Para la desensibilización de GPCR

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Biomo tercer parcial (8 decks)

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