Severson Abnormal CV development Flashcards

1
Q

name 3 left to right shunts

A

atrial septal defect
ventral septal defect
patent ductus arteriosus

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2
Q

name 3 right to left shunts

A

teratology of fallot
transposition of great arteries
truncus arteriosus

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3
Q

which type of shunt makes blue babies?

A

right to left

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4
Q

what is the most common congenital heart abnormality?

A

ventricular septal defect

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5
Q

What abnormality is associated with maternal rubella during early pregnancy?

A

Patent ductus arteriosus

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6
Q

what abnormality produces a machine-like murmur?

A

PDA

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7
Q

What are the 4 defects in Tetralogy of Fallot?

A
Pulmonary stenosis
Right ventricular hypertrophy
Overriding aorta
Ventricular septal defect
e 
(PROVe)
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8
Q

What embryological defect causes a transposition of the great arteries?

A

A straight division of the bulbus cordis and truncus arteriosus (failure of normal spiraling of the aorticopulmonary septum)

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9
Q

a transposition of the great arteries is incompatible with life unless what is present?

A

A patent ductus arteriosus

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10
Q

What defect is particularly common in offspring of diabetic motheres?

A

transposition of great arteries

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11
Q

What causes a truncus arteriosus?

A

Failur of bulbar and truncal ridges to develop

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12
Q

what is a truncus arteriosus defect?

A

a common aorticopulmonary outlet, receiving blood from both ventricles

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13
Q

What are the 2 forms of a coractation of the aorta?

A

Infantile (preductal) and Adult (postductal)

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14
Q

In the postductal form, what happens?

A

constriction of aorta distal to ligamentum arteriosum

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15
Q

what happens in the preductal form?

A

narrowing of aortic segment between subclavian artery (left) and ductus arteriosus (patent)

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16
Q

What heart defects are associated with down syndrome?

A

Atrial and ventricular septal defects

17
Q

what happens in dextrocardia?

A

Heart folds left instead of right

18
Q

What does the bulbus cordis become?

A

Conus arteriosus and aortic vestibule

19
Q

What does the truncus arteriosus become?

A

gives rise to the ascending aorta and pulmonary trunk

20
Q

What developmental structures serves to divide the atrioventricular canal into R and L channels?

A

Endocardial cushions

21
Q

What do the endocardial cushions contribute to?

A

divides AV canal into R and L channels
membranous poriton of interventricular septum
closure of primary interatrial foramen

22
Q

which septum are the primary and secondary foramina associated with?

A

primary

23
Q

which septum forms the foramen ovale?

A

secondary

24
Q

what are the bulbar and truncus ridges derived from?

A

Neural crest mesenchyme

25
Q

what forms the membranous portion of the interventricular septum?

A

endocardial cushions and bulbar ridges fuse

26
Q

what does the distal portion of the left 6th aortic arch form?

A

ductus arteriosus

27
Q

what does the proximal portion of the left 6th aortic arch form?

A

proximal part of left pulmonary artery

28
Q

what does the proximal portion of the right 6th aortic arch form?

A

proximal part of right pulmonary artery

29
Q

what does the right 4th aortic arch form?

A

Right subclavian artery

30
Q

what does the left 4th aortic arch form?

A

aortic arch

31
Q

what 2 things does the aortic sac contribute to?

A

brachiocephalic trunk and arch of aorta

32
Q

what drug is used to close a ductus arteriosus in newborns?

A

Indomethacin

33
Q

what drug can keep a ductus arteriosus open in newborns?

A

PG E