Severson Abnormal CV development Flashcards
name 3 left to right shunts
atrial septal defect
ventral septal defect
patent ductus arteriosus
name 3 right to left shunts
teratology of fallot
transposition of great arteries
truncus arteriosus
which type of shunt makes blue babies?
right to left
what is the most common congenital heart abnormality?
ventricular septal defect
What abnormality is associated with maternal rubella during early pregnancy?
Patent ductus arteriosus
what abnormality produces a machine-like murmur?
PDA
What are the 4 defects in Tetralogy of Fallot?
Pulmonary stenosis Right ventricular hypertrophy Overriding aorta Ventricular septal defect e (PROVe)
What embryological defect causes a transposition of the great arteries?
A straight division of the bulbus cordis and truncus arteriosus (failure of normal spiraling of the aorticopulmonary septum)
a transposition of the great arteries is incompatible with life unless what is present?
A patent ductus arteriosus
What defect is particularly common in offspring of diabetic motheres?
transposition of great arteries
What causes a truncus arteriosus?
Failur of bulbar and truncal ridges to develop
what is a truncus arteriosus defect?
a common aorticopulmonary outlet, receiving blood from both ventricles
What are the 2 forms of a coractation of the aorta?
Infantile (preductal) and Adult (postductal)
In the postductal form, what happens?
constriction of aorta distal to ligamentum arteriosum
what happens in the preductal form?
narrowing of aortic segment between subclavian artery (left) and ductus arteriosus (patent)
What heart defects are associated with down syndrome?
Atrial and ventricular septal defects
what happens in dextrocardia?
Heart folds left instead of right
What does the bulbus cordis become?
Conus arteriosus and aortic vestibule
What does the truncus arteriosus become?
gives rise to the ascending aorta and pulmonary trunk
What developmental structures serves to divide the atrioventricular canal into R and L channels?
Endocardial cushions
What do the endocardial cushions contribute to?
divides AV canal into R and L channels
membranous poriton of interventricular septum
closure of primary interatrial foramen
which septum are the primary and secondary foramina associated with?
primary
which septum forms the foramen ovale?
secondary
what are the bulbar and truncus ridges derived from?
Neural crest mesenchyme
what forms the membranous portion of the interventricular septum?
endocardial cushions and bulbar ridges fuse
what does the distal portion of the left 6th aortic arch form?
ductus arteriosus
what does the proximal portion of the left 6th aortic arch form?
proximal part of left pulmonary artery
what does the proximal portion of the right 6th aortic arch form?
proximal part of right pulmonary artery
what does the right 4th aortic arch form?
Right subclavian artery
what does the left 4th aortic arch form?
aortic arch
what 2 things does the aortic sac contribute to?
brachiocephalic trunk and arch of aorta
what drug is used to close a ductus arteriosus in newborns?
Indomethacin
what drug can keep a ductus arteriosus open in newborns?
PG E
