Set 1 Flashcards
Temporal arteritis labs/tx
ESR elevated; needs biopsy; ophtho for mgmt
Elevated WBC >12,000
Neutrophilia
Neutrophilia with bands
Left shift
Avulsed tooth
Transport in cold milk or commercial “Save-a-tooth”
Sensitivity
Ability of a test to detect a person with a disease
Specificity
Ability of a test to detect a person who is healthy
Cohort study
Follows a group who share some common characteristics: try to observe development of disease over time
Keisselbach’s plexus
Anterior epistaxis
Initial action
Interview
Gold standard test: sickle cell, thalasemia, G6PD
Hemoglobin electrophoresis
Allergy to PCNs: gram+ infection
Macrolide or clindamycin
Acute mononucleosis
usually teen with fatigue, sore throat, cervical LAD; if older patient may be mono reactitvation
Alpha thalasemia
Southeast Asians Filipinos
Iron deficiency anemia
Pica or spoon shaped nails
SLE
butterfly or malar rash
Polymyalgia rheumatica (PMR) tx
1st: long term steroids *long term risk for temporal arteritis
Finkelsteins
de Quervain’s tenosynovitis: pain aggravatted by passively stretching thumb tendons over the radial styloid in the flexion
Anterior drawer
+in ACL tear
McMurrays
Checks for meniscal injury: with patient lying flat (supine), knee fully flexed; grasp heel; leg is rotated on the thigh with the knee in full flexion and out of flexion; internally and externally rotate checking for a click
Diabetic retinopathy eye sx
neovascularization, hard exudates, cotton wool spots, microaneurysms
HTN retinopathy
AV nicking, silver wire/copper wire arterioles
DTR grading
0=absent; 1=hypoactive; 2=normal; 3=hyperactive; 4=clonus
S4
Benign in some elderly
Cutaneous anthrax
Cipro 500mg PO BID x 60 days or doxy 100 PO BID
Primary prevention
“prevention” performing actions to prevent a condition from occuring
Secondary
“detection” screenings: breast exam; genital self-exam
tertiary
“rehab” preventing complications, education, support groups, med side effects, limiting further harm
Bacterial vaginosis
alkaline ph (normal vag ph =4.0)-BV only vag condition with alkaline ph
Clue cells
BV: “mature squamous epithelial cells with numerous bacteria noted on cell borders”
Candida
Yeast: DC white curdlike with redness and itching; see WBCs, psseudohyphae, spores “spaghetti and meatballs”
Trichomonas
copious discharge, bubbly, green; +inflammation, itching, redness; considered STI–> treat partner
HCTZ side effect
hyperuricemia and hyperglycemia
CAP 1st line tx
macrolides
mortality
most common cause of death
morbidity
most common cause of disease
most common cancer death
lung cancer
most common cancer
skin
CDC mortality: dz most deaths
CVD
cancer highest mortality
lung
most common cause death adolescents
MVA
Cancer prevalence: female
breast; not considered a gyn cancer
cancer prevalence male
prostate
most common skin cancer
basal cell
highest skin cancer mortality
melanoma
GYN cancers
vulva, vaginal, cervix, uterine, ovary
most common gyn cancer
uterine; ovarian #2
torus palatinus
bony growth midline at hard palate of mouth, covered with normal oral skin; painless; does not affect function
geographic tongue
multiple fissures; irregular smoother area on surface; looks like topo map; benign
leukoplakia
not benign: slow growing white plaque that has a firm hard surface—> precancerous lesion requires biopsy: cause poorly fitting denturs or chewing tobacco
oral/hair leukoplakia
painless white patch: appears corrugated on lateral tongue: HIV/AIDS, EBV of tongue
breast screening
mammo w/wo CBE start age 50, then every 2 years until age 75; women 40-49 mammo based on individual risk factors and history
ovarian cancer screening
no recommended regular screening
ovarian cancer
older female c/o abd or pelvic symptoms, stomach bloating, low back ache, constipation: palpate ovary; must r/o ovarian cancer in any woman with palpable ovary
population for ovarian cancer workup
early menarche, late menopause, endometriosis, PCOS, fam hx, +BRCA 1/2; initial CA125; intravag US
AAA screenign
1 time (male 65-75) with 30+ pack year smoking history
Barretts esophagitis
precancerous lesion of esophagus
Tanner stage 1 male and female
pre-puberty
Tanner stage 2 female
breast bud/areola start to develop
Tanner stage 3 female
breast bud/areola continue to grow (one mound no separation)
Tanner stage 4 female
nipples/areola become elevated from breast (secondary mound)
Tanner stage 5 male and female
adult characteristics
Tanner stage 2 male
testes with scrotum enlargement (scrotal skin starts to darken with more ruggae)
Tanner stage 3 male
penis grows larger (length) scrotum continues to enlarge
Tanner stage 4 male
penis wider
physiologic gynecosmastia
disc-like breast tissue, mastitis, asymetrical,
pseudogynecomastia
increased risk with overweight/obese
high potassium foods
potatoes, apricots, brussel sprouts
high tyramine foods
aged cheese, red wine, chocolate (increased reactions with MAOIs)
Gluten
avoid in celiac disease (wheat, rye, barley, oats)
Gluten free
corn, rice, potato, soy, tapioca
High mag foods
(decrease BP, dilates blood vessels): some nuts, beans, whole wheat
asthma child outcome
ability to attend school full-time and to play normally every day
Anaphylaxis tx primary care
epi 1:1000 o.3mg IM then 911
anaphylaxis in ED
oxygen, IV, epi, H2 blockers, H1 blockers, bronchodilator, systemic glucocorticoids
anaphylaxis
type 1 IgE mediated; may have biphasic reaction–>reoccurs within 8-10 hours. prescribe medrol dose pack
Elderly patient with weight loss
high rate of complications and increased risk death
Pathologic weight loss
unintentional weight loss >10%
maculopapular
has color and texture-small papules on red or raised skin lesions
varicella
maculaopapular with papules, vesicles, and crusts
fifth dz
maculopapular rash in lace-like pattern
pityriasis rosea (PR)
herald pathc; christmas tree pattern
vesicular rash on erythematous base
herpes simplex, genital herpes
scabies
nighttime pruritic rash, family members with similar symptoms, finger wens, waist, penis; treat all family members same time, wash all clothing, linen in hot water; high heat
S3 heart sound best heard
pulmonic area; pathognomic for heart failure
PPD
measure induration
pulmonary tb gold standard
sputum cx; treat with 3 drug regimin; reportable
INH therapy (isoniazid)
baseline lft and repeat monitoring
DJD
OA
atopic dermatitis
eczema
senile arcus
arcus senilis
acute otitis media (AOM)
purulent OM
serous OM
OME
group A beta strept
strept pyogenes
tinea corporis
ringworm
enterobiasis
pinworms
vitamin B12
cobalamin; cyanocobalamin
vitamin b1
thiamine
scarlet fever
scarletina
otitis externa
swimmer’s ear
condyloma acuminata
genital warts
tic doloureaux
trigeminal neuralgia
tinea cruris
jock itch
thalassemia minor
thalassemia trait (alpha/beta)
giant cell arteritis
temporal arteritis
psoas sign
ilipsoas sign
tinea capitas
ringworm of scalp
light reflex
Hirscberg test
sentinel nodes
Virchow’s nodes: left supraclavicular fossa
erythema migrans
early stage of lyme disease
SSRI
1st line MDD/OCD
benzos
anxiety/insomnia
mood stabilizer (lithium)
bipolar
TCAs
2nd line for depression; prophylactic for migraines, chronic pain, neuropathic pain *no TCA for SI–OD risk
carbamazepine
tegretol: anticonvulsant also used for chronic pain and trigeminal neuralgia
CAGE
screening for ETOH; cut down. annoyed by comments, guilt about drinking, early AM drinking
HTN JNC7 Stage 1 treatment
THiazide: good for osteopenia/osteoporosis: decreases calcium excretion by kidneys and stimulates osteoclast activity resulting in bone formation
ACEI
HTN with DM
HTN with migrains
beta blockers (without lung diseases)
Diverticula
usually asymptomatic, small polyps on colon wall diagnosed via colonoscopy, cause low intake of fiber, rare for those less than 50. mild cases managed OP: ABX cipro 500mg PO BID with flagyl 500mg PO TID x 10-14 days; recommend fiber and psyllium; diverticulitis if develops can be life-threatening
Rocky Mountain Spotted Fever
Emergent condition (Rickettsia Rickettsia): south central US, outdoor activities; presents classic rash wrists/ankles spreading centrally with involvement of palms/soles. systemic sx high feverm HA, myalgia, nausea. treat w/in forst 8 days or fatal. refer to ED. may be difficult to distinguish between meningococcemia and RMSF before BCx and LP. Doxycycline 100mg PO /IV x 7days
Lyme disease
Mid atlantic/new england states; erythema migrans rash; ixodes-deer tick bite; Spirochette Borrelia; doxycycline x 21 days
Menarche
cycle is irregular: months -2 years before
Leading causes of death in teens
1 cause of death in teens MVA; Homicide #2
Emancipated minor
<18: has full legal rights of adult; minors who are parents are not emancipated unless married. Criteria for emancipation: married, enlisted, legal emancipation
Angina
classic presentation CP precip by exertion, relieved by rest; history: several episodes of the same plus risk factors age, gender, lipids
AAA
pulsatile mass mid abd with bruit; older white male with hx smoking; rupture is abrupt, severe abd pain with low back pain, abd distension and shock sx
Tay-Sachs
Ashkanazi Jewish: progressive fatal disease, inherited, build up of plaques in brain-fatal
eGFR
sensitive indicator of renal function: <60 =kidney damage; affected by age, less sensitive in elderly; males higher; increased in african americans
BUN
waste products of protein intake: increased intake=increased levels; dehydration =increased BUN
Warfarin interaction
Bactrim; sulfa drugs interact with warfarin (increased levels=increased INR=inreased bleeding risk)
oral drugs 1st pass metabolism
drug swallowed-gi tract absorbs-portal circulation-liver metabolizes/biotransforms-releases systemic circ
1st pass metab
lowers amount of active drug available to body; drugs with high first pass effect-mostly deactivated and cannot be used by body; example is swallowed insulin-broken down in GI tract-bypassed by injection
drug metabolism
biotransformation: most active in liver (cytochrome p450 enzyme system) kidneys, gi, liver
drug excretion
liver-excreted in bile, urine, feces, resp gas (CO2), and sweat, most drugs are excreted in 2 or more systems
1/2 life
amount of time drug content decreased by 50%
area under curve
average amount of drug in blood after a dose given-measure of bioavailability after drug administered
minimum inhibitory concentration
lowest concentration of antibiotic that will inhibit growth of organisms
max concentration
highest concentration of drug after dose
trough
minimum concentration of drug after dose
problematic drugs-potent inhibitors of cytochrome p450
inhibits or slows drug clearance: increased risk of OD; macrolides, antifungals, cisapride, cimetidine, citalopram
narrow therapeutic index drugs
warfarin, digoxin, theophylline, carbamazepine, phenytoin, levothyroxine, lithium (check blood levels and TSH)
Pioglitazone (Actos)
a TZD: exacerbates CHF; do not use if CHF class 3 or 4, stop if develops SOB, weight gain, cough
atypical antipsychotics
resperidal, olanzapine, quietipine: increased weight gain, dm; monitorweight; black box for increased mortality in elderly; monitor tsh, lipids, bmi
bisphosphonates
alendronate; jaw pain/necrosis, CP diff swallowing, burning back pain; perfed viscous; take solo upon awakening with 8oz water (no juice), remain upright for 30 min
Statins
no mixing with grapefruit juice, drug induced hepatitis/rhabdo, high dose zocor highest risk rhabdo,
digoxin
ti 0.5-2; dig toxic/od anorexia, nausea, vomiting, arrythmias, confusion, visual changes (yellow-green)-digibind for severe toxicity
coumadin od
inr 5-9 w/o bleeding: hold warfarin 1-2 doses, recheck inr in 2-3 days until stable 2-3, once stable recheck monthly
coumadin and inr <2
stroke risk increased 6x;
thiazide diuretics
uncomp 1st line HTN agent; avoid with sulfa allergies; beneficial in osteoporosis; advers hyperglycemia, increased trigs, increased uric acid, hypokalemia
potassium sparing diuretics
alt to thiazides if sulfa allergic; black box warning for hyperkalemia; increased risk if renal impariment, dm, elderly; monitor serum k. advise no salt substitutes or k supplements, caution with ACEI/ARB increased risk hyperkalemia
Loop diuretics
Lasix/Bumex; indication for edema 2/2 chf; cirrhosis, renal disease, htn; excreted via loop of henle; more potent than hctz; adverse electrolyte changes hypokalemia, hyponatremia, decreased chloride; hypovolemia; hyponatremia; pancreatitis, jaundice, rash, ototoxic
Aldosterone antagonists
spironolactoneL indicatedhirsutism, htn, severe chf; advers galactorrhea, hyperkalemia; rare use in primary care 2/2 adverse affects; increased risk of cancers; black box increased risk of benign and malignant tumors
Beta blockers (beta antagonists)
indication: htn, post mi, angina, arrythmias, migraine prophylaxis; adjunct hyperthyroid, thyrotoxicosis; glaucoma=timolol; cardioselective =B1 only; adverse =bronchospasm, bradycardia, depression, fatigue, ercetile dysfunction, blunts hypoglycemic response (caution with DM patients)
ACEI/ARB
indication: HTN, DM, CKDavoid in pregnancy; adverse angioedema and anaphylaxis; ACEI=cough, hyperkalemia; cough usually in the first few months dry and hacking
CCB
indications: HTN, raynauds phenom; DHP vs non-dhp; do not give verapamil with erythromycin or clarithromycin; avoid with grapefruit juice; adverse is headache, peripheral edema, bradycardia, heart block, hypotension, qt prolongationconstipation most common side effect
Alpha blockers
indication: htn with coexisting BPH; terazosin (hytrin) 1mg PO qHS, not first line treatment except htn with bph; potent vasodilator; side effect dizzy/hypotension; severe fall risk at night–advise elderly
pharyngitis
Group A beta strept (pyogenes) 1st line=amoxicillin or pcn vk; if allergic give clarithromycin 250mg PO BID x10days (alternative to pcns is macrolides=azithromycin or clarithromycin)
Mono with strept throat
+mono spot and +cx GAS; avoid using amoxicilin or ampicillin 2/2 rash; use pcn vk or macrolide