Session 4: Oncology Rearrangements

Question 1

ALL - BCR-ABL1

Answer 1

t(9;22)(q34;q11)

Question 2

ALL - t(4;11)(q21;q23)

Answer 2

KMT2A-AFF1

Question 3

ALL - PAX5-ETV6

Answer 3

dic(9;12)(p13;p13)

Question 4

AML FAB Class M5 - t(9;11)(p21;q23)

Answer 4

KMT2A-MLLT3

Question 5

ETV6-RUNX1

Answer 5

ALL - t(12;21)(p13q22)

Question 6

ALL - t(1;19)(q23;p13)

Answer 6

TCF3-PBX1

Question 7

ALL - TCF3-HLF

Answer 7

t(17;19)(q22;p13)

Question 8

AML FAB class M2

Answer 8

t(8;21)(q22;q22) RUNX1T1-RUNX1

Question 9

AML FAB Class M4

Answer 9

t(16;16) or inv(16)(p13.1q22) - CBFB-MYH11

Question 10

PML-RARA

Answer 10

APL t(15;17)(q24;q21)

Question 11

AML - RPN1-MECOM

Answer 11

inv(3)(q21q26.2)

Question 12

AML (megakaryoblastic) FAB Class M7 - RBM15-MKL1

Answer 12

t(1;22)(p13;q13)

Question 13

CML (an easy one to make you happy)

Answer 13

t(9;22)(q34;q11) - BCR-ABL1

Question 14

Burkitt Lymphoma - MYC-IGH

Answer 14

t(8;14)(q24;q32)

Question 15

Burkitt Lymphoma - t(8;22)(q24;q11)

Answer 15

MYC-IGL

Question 16

Burkitt Lymphoma - MYC-IGK

Answer 16

t(2;8)(p12;q24)

Question 17

BCL2-IGH - Follicular Lymphoma

Answer 17

t(14;18)(q32;q21)

Question 18

Mantle Cell Lymphoma

Answer 18

t(11;14)(q13;q32) - IGH-CCND1

Question 19

Diffuse Large B Cell Lymphoma - BCL6-IGH

Answer 19

t(3;14)(q27;q32)

Question 20

BIRC3-MALT1

Answer 20

Marginal zone B-Cell Lymphoma - t(11;18)(q21;q21)

Question 21

MALT Lymphoma - IGH-MALT1

Answer 21

t(14;18)(q32;q21)

Question 22

MALT Lymphoma - IGH-BCL10

Answer 22

t(1;14)(p22;q32)

Question 23

t(2;5)(p23;q25) - ALK-NPM

Answer 23

Anaplastic Large Cell Lymphoma

Question 24

Anaplastic Large Cell Lymphoma t(1;2)(q25;p23)

Answer 24

ALK/TPM3

Question 25

PAX7-FOXO1

Answer 25

Alveolar Rhabdomyosarcoma - t(1;13)(p36;q14)

Question 26

PAX3-FOXO1

Answer 26

Alveolar Rhabdomyosarcoma - t(2;13)(q35;q14)

Question 27

SYT-SSX1

Answer 27

Synovial sarcoma - t(X;18)(p11.23;q11.2)

Question 28

SYT-SSX2

Answer 28

Synovial sarcoma - t(X;18)(p11.22;q11.2)

Question 29

Ewings Sarcoma - t(11;22)(q24;q12)

Answer 29

EWS-FLI1

Question 30

t(11;22)(p13;q12) EWS-WT1

Answer 30

Desmoplastic Small Round Cell Tumour

Question 31

Infantile Fibrosarcoma - ETV6-NTRK3

Answer 31

t(12;15)(p13;q25)

Question 32

tMDS - DEK-NUP214

Answer 32

t(6;9)(p22;q34)

Question 33

Mixoid/ round cell liposarcoma - DDIT3-FUS

Answer 33

t(12;16)(q13;p11)

Question 34

Ewings Sarcoma - EWS-ERG

Answer 34

t(21;22)(q12;q12)

Question 35

Ewings Sarcoma - t(7;22)(p22;q12)

Answer 35

EWS-ETV1

Question 36

t(12;22)(q13;q12) - EWS-DDIT3

Answer 36

Myxoid/round cell liposarcoma

Question 37

Extraskeletal mixoid chondrosarcoma

Answer 37

t(9;22)(q22.3;q12.2) - nR4A3-EWS

Question 38

What is the location of KMT2A?

Answer 38

11q23

Question 39

What is the location of TCF3?

Answer 39

19p13

Question 40

Karotype of BCR-ABL1?

Answer 40

t(9;22)(q34;q11)

Question 41

Karyotype of ETV6-RUNX1?

Answer 41

t(12;21)(p13;q22)

Question 42

Karyotype of RUN1T1-RUNX1?

Answer 42

t(8;21)(q21;q22)

Question 43

Karyotype of AFF1-KMT2A

Answer 43

t(4;11)(q21;q23)

Question 44

Karyotype of TCF3-HLF?

Answer 44

t(17;19)(q22;p13)

Question 45

Karyotype of PBX1-TCF3?

Answer 45

t(1;19)(q23;p13)

Question 46

What is the location of IGH?

Answer 46

14q32

Question 47

What is the location of TP53?

Answer 47

17p13

Question 48

What is the location of RB1?

Answer 48

13q14

Question 49

Karyotype of CBFB-MYH11?

Answer 49

inv(16)(p13q22) or t(16;16))

Question 50

Karyotype of PML-RARA?

Answer 50

t(15;17)(q24;q21)

Question 51

Karyotype of MLLT3-KMT2A?

Answer 51

t(9;11)(p22;q23)

Question 52

What is the location of FLT3?

Answer 52

13q12

Question 53

What is the location of ATM?

Answer 53

11q23