Session 14 - Group Work Flashcards

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6
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Hayfever meds

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7
Q

Case 1
Mr Taylor is a 91 year old retired sheep farmer from Derbyshire. He has recently moved with his wife of 68 years from the farm house into the adjacent single story farm cottage. He uses a stick to mobilise due to osteoarthritic hip pain and reluctantly wears bifocals when he can find them. His wife suffers from vascular dementia. He is her primary carer and continues to drive her to a day centre twice a week. He fiercely guards his independence and collects and manages both his and his wife’s medications himself.

Past medical history:
Hypertension, benign prostatic hyperplasia, osteoarthritis, type II diabetes mellitus, hay fever and newly reported nocturia.

Whilst discussing his medications Mr Taylor reports that he has fallen or nearly fallen on a number of occasions in the last three months.

Mr Taylor reports that the falls have occurred upon standing to attend to his wife. He confirms that although he feels pain in his hip, he doesn’t feel that this is making him fall. He reports feeling dizzy and then remembering mobilising himself from the floor with the help of his armchair and or walking stick.

His ECG shows sinus rhythm and observations demonstrated a lying BP of 128/84. Upon standing his BP drops to 96/75 within 1 minute and he reports symptoms of dizziness.

  1. What could you recommend to help with the nocturia? If you haven’t already, you may want to consider doses in your answer.
A
  • Avoid caffeine PM
  • Drink less before bed
  • Keep a fluid chart to ascertain what makes the nocturia worse
  • Decrease thiazide diuretic
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8
Q

Case 1
Mr Taylor is a 91 year old retired sheep farmer from Derbyshire. He has recently moved with his wife of 68 years from the farm house into the adjacent single story farm cottage. He uses a stick to mobilise due to osteoarthritic hip pain and reluctantly wears bifocals when he can find them. His wife suffers from vascular dementia. He is her primary carer and continues to drive her to a day centre twice a week. He fiercely guards his independence and collects and manages both his and his wife’s medications himself.

Past medical history:
Hypertension, benign prostatic hyperplasia, osteoarthritis, type II diabetes mellitus, hay fever and newly reported nocturia.

Whilst discussing his medications Mr Taylor reports that he has fallen or nearly fallen on a number of occasions in the last three months.

Mr Taylor reports that the falls have occurred upon standing to attend to his wife. He confirms that although he feels pain in his hip, he doesn’t feel that this is making him fall. He reports feeling dizzy and then remembering mobilising himself from the floor with the help of his armchair and or walking stick.

His ECG shows sinus rhythm and observations demonstrated a lying BP of 128/84. Upon standing his BP drops to 96/75 within 1 minute and he reports symptoms of dizziness.

Mr Taylor reports that he self prescribes ibuprofen to manage osteoarthritic hip pain.
What advice would you give him?

  1. What other drugs may you consider?
A

Ibuprofen has causes kidney problems, so this gentleman because elderly already has a low eGFR.

  • Paracetamol
  • Co-codamol
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9
Q

Case 1
Mr Taylor is a 91 year old retired sheep farmer from Derbyshire. He has recently moved with his wife of 68 years from the farm house into the adjacent single story farm cottage. He uses a stick to mobilise due to osteoarthritic hip pain and reluctantly wears bifocals when he can find them. His wife suffers from vascular dementia. He is her primary carer and continues to drive her to a day centre twice a week. He fiercely guards his independence and collects and manages both his and his wife’s medications himself.

Past medical history:
Hypertension, benign prostatic hyperplasia, osteoarthritis, type II diabetes mellitus, hay fever and newly reported nocturia.

Whilst discussing his medications Mr Taylor reports that he has fallen or nearly fallen on a number of occasions in the last three months.

Mr Taylor reports that the falls have occurred upon standing to attend to his wife. He confirms that although he feels pain in his hip, he doesn’t feel that this is making him fall. He reports feeling dizzy and then remembering mobilising himself from the floor with the help of his armchair and or walking stick.

His ECG shows sinus rhythm and observations demonstrated a lying BP of 128/84. Upon standing his BP drops to 96/75 within 1 minute and he reports symptoms of dizziness.

Mr Taylor reports that he self prescribes ibuprofen to manage osteoarthritic hip pain.
What advice would you give him?

  1. In accordance with the STOPP START guidelines would you recommend initiating any other medications?
A

START - Statins e.g. atorvastatin
bc he is diabetic with >1 co-existing major CV risk factor (in this case, HT)

Remember: Statins interact with grapefruit juice (CYP 3A4!)

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10
Q

Case 1
Mr Taylor is a 91 year old retired sheep farmer from Derbyshire. He has recently moved with his wife of 68 years from the farm house into the adjacent single story farm cottage. He uses a stick to mobilise due to osteoarthritic hip pain and reluctantly wears bifocals when he can find them. His wife suffers from vascular dementia. He is her primary carer and continues to drive her to a day centre twice a week. He fiercely guards his independence and collects and manages both his and his wife’s medications himself.

Past medical history:
Hypertension, benign prostatic hyperplasia, osteoarthritis, type II diabetes mellitus, hay fever and newly reported nocturia.

Whilst discussing his medications Mr Taylor reports that he has fallen or nearly fallen on a number of occasions in the last three months.

Mr Taylor reports that the falls have occurred upon standing to attend to his wife. He confirms that although he feels pain in his hip, he doesn’t feel that this is making him fall. He reports feeling dizzy and then remembering mobilising himself from the floor with the help of his armchair and or walking stick.

His ECG shows sinus rhythm and observations demonstrated a lying BP of 128/84. Upon standing his BP drops to 96/75 within 1 minute and he reports symptoms of dizziness.

Mr Taylor reports that he self prescribes ibuprofen to manage osteoarthritic hip pain.
What advice would you give him?

  1. Beyond reviewing Mr Taylor’s medications what else may improve his adherence and that of his wife?
A
  • Pill box
  • ## Home assessment by Occupational Therapy/Physiotherapist
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11
Q

What is the drug class of aspirin 75 mg o.d.?

A

Antiplatelet drugs

NSAIDs

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12
Q

What is the indication for aspirin 75mg o.d.?

A

CV disease (secondary prevention); TIA; following coronary bypass surgery;

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13
Q

What is the drug class of clopidogrel 75 mg o.d.?

A

Antiplatelets

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14
Q

What is the indication for clopidogrel 75mg o.d.?

A

TIA; prevention of atherothrombotic events in peripheral arterial disease, acute myocardial infarction with ST-elevation or AF

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15
Q

What is the drug class of amlodipine 10mg o.d.?

A

Dihydropyridine CCB

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16
Q

What is the indication for amlodipine 10mg o.d.?

A

Prophylaxis of angina; hypertension

17
Q

What is the drug class of Spiriva Respimat(R) 2 puffs o.d.?

A

Anticholerginic

Tiotropium bromide

18
Q

What is the indication of Spiriva Respimat(R) 2 puffs o.d.?

A

COPD and asthma

19
Q

What is the drug class of Sinemet(R) Plus 25/100 mg 3 tablets t.d.s?

A

x

20
Q

What is the indication of Sinemet(R) Plus 25/100 mg 3 tablets t.d.s?

A

x

21
Q

What is the drug class of ranitidine 150mg b.i.d. (been on repeat for 3 months)?

A

x

22
Q

What is the indication of ranitidine 150mg b.i.d. (been on repeat for 3 months)?

A

x

23
Q

What is the drug class of prednisolone 30mg o.d. 7 day course?

A

x

24
Q

What is the indication of prednisolone 30mg o.d. 7 day course?

A

x

25
Q

Case 2

Ms Reynolds is a 64 year old retired art teacher. She retired early on grounds of ill health after being diagnosed with COPD 4 years ago. She had a 30 pack-year smoking habit which she stopped upon diagnosis. She was also diagnosed with idiopathic Parkinson’s disease during a prolonged hospital stay 13 months ago following an MI. She lives independently in her own home, with regular visits from her son and daughter who help with house-hold chores. She has started to struggle mobilising due to breathlessness but still goes out with the aid of taxis and a walker seat.

You need to consider the indication for each of the medications that have been reported.

In the process of reviewing Ms Reynolds medications, it is again important to consider what and when she is taking her medications.

  1. Before considering any potential ADRs and DDIs what questions may you want to ask her?
A
  • Are you experiencing any side effects?

- How are you managing with taking them (including compliance)?

26
Q

Case 2

Ms Reynolds is a 64 year old retired art teacher. She retired early on grounds of ill health after being diagnosed with COPD 4 years ago. She had a 30 pack-year smoking habit which she stopped upon diagnosis. She was also diagnosed with idiopathic Parkinson’s disease during a prolonged hospital stay 13 months ago following an MI. She lives independently in her own home, with regular visits from her son and daughter who help with house-hold chores. She has started to struggle mobilising due to breathlessness but still goes out with the aid of taxis and a walker seat.

You need to consider the indication for each of the medications that have been reported.

In the process of reviewing Ms Reynolds medications, it is again important to consider what and when she is taking her medications.

  1. What potential interactions should be considered in Ms Reynolds’ script?
A

CCB and clopidogrel

27
Q

Case 2

Ms Reynolds is a 64 year old retired art teacher. She retired early on grounds of ill health after being diagnosed with COPD 4 years ago. She had a 30 pack-year smoking habit which she stopped upon diagnosis. She was also diagnosed with idiopathic Parkinson’s disease during a prolonged hospital stay 13 months ago following an MI. She lives independently in her own home, with regular visits from her son and daughter who help with house-hold chores. She has started to struggle mobilising due to breathlessness but still goes out with the aid of taxis and a walker seat.

You need to consider the indication for each of the medications that have been reported.

In the process of reviewing Ms Reynolds medications, it is again important to consider what and when she is taking her medications.

  1. In conjunction with the STOPP START tool, would you recommend removing any drugs? What about reviewing dose or use of any others?
A

STOPP - clopidogrel (no added benefit of dual therapy: two antiplatelets)
Stop amlodipine

28
Q

Case 2

Ms Reynolds is a 64 year old retired art teacher. She retired early on grounds of ill health after being diagnosed with COPD 4 years ago. She had a 30 pack-year smoking habit which she stopped upon diagnosis. She was also diagnosed with idiopathic Parkinson’s disease during a prolonged hospital stay 13 months ago following an MI. She lives independently in her own home, with regular visits from her son and daughter who help with house-hold chores. She has started to struggle mobilising due to breathlessness but still goes out with the aid of taxis and a walker seat.

You need to consider the indication for each of the medications that have been reported.

In the process of reviewing Ms Reynolds medications, it is again important to consider what and when she is taking her medications.

  1. In accordance with the STOPP START guidelines would you recommend initiating any other medications?
A

START

  • Replace amlodipine with ACEi
  • Statins
29
Q

Case 2

Ms Reynolds is a 64 year old retired art teacher. She retired early on grounds of ill health after being diagnosed with COPD 4 years ago. She had a 30 pack-year smoking habit which she stopped upon diagnosis. She was also diagnosed with idiopathic Parkinson’s disease during a prolonged hospital stay 13 months ago following an MI. She lives independently in her own home, with regular visits from her son and daughter who help with house-hold chores. She has started to struggle mobilising due to breathlessness but still goes out with the aid of taxis and a walker seat.

You need to consider the indication for each of the medications that have been reported.

In the process of reviewing Ms Reynolds medications, it is again important to consider what and when she is taking her medications.

  1. It is decided that the dose of Sinemet(R) Plus should be increased to help with worsening motor symptoms. What side effects should you warn Ms Reynolds about?
A
  • Nausea and vomiting
  • Drowsiness
  • Seizure
  • ‘Wearing off’ sensation of drug (i.e. you feel you need more dopamine)
30
Q

Case 2

Ms Reynolds is a 64 year old retired art teacher. She retired early on grounds of ill health after being diagnosed with COPD 4 years ago. She had a 30 pack-year smoking habit which she stopped upon diagnosis. She was also diagnosed with idiopathic Parkinson’s disease during a prolonged hospital stay 13 months ago following an MI. She lives independently in her own home, with regular visits from her son and daughter who help with house-hold chores. She has started to struggle mobilising due to breathlessness but still goes out with the aid of taxis and a walker seat.

You need to consider the indication for each of the medications that have been reported.

In the process of reviewing Ms Reynolds medications, it is again important to consider what and when she is taking her medications.

  1. What considerations would need to be made if offering additional therapeutics to manage these side effects?
A
  • Side effects of additional therapeutics including MAObs, COMT inhibitors, anticholinergics,
31
Q

Case 2

Ms Reynolds is a 64 year old retired art teacher. She retired early on grounds of ill health after being diagnosed with COPD 4 years ago. She had a 30 pack-year smoking habit which she stopped upon diagnosis. She was also diagnosed with idiopathic Parkinson’s disease during a prolonged hospital stay 13 months ago following an MI. She lives independently in her own home, with regular visits from her son and daughter who help with house-hold chores. She has started to struggle mobilising due to breathlessness but still goes out with the aid of taxis and a walker seat.

You need to consider the indication for each of the medications that have been reported.

In the process of reviewing Ms Reynolds medications, it is again important to consider what and when she is taking her medications.

Ms Reynolds’ daughter has observed that her mother appears drowsy on a number of occasions when she has come to visit. Ms Reynolds says that she has found herself drinking more water over the same period.

  1. What do you think may be contributing to these observations? Could you make any adjustments to her medications to reduce the drowsiness and thirst?
A

Spiriva is an antimuscarinic which can cause dry mouth.

The antihistamine - ranitidine - is probably causing the drowsiness.

32
Q

Case 3

A 36 year old male with a history of depressive illness and alcohol dependence has been prescribed a compound analgesic (co-codamol 30/500) for a severely sprained ankle. 24 hours after collecting his prescription he is found by his partner asleep on the sofa next to the empty packet of pain killers and 6 empty strong cider cans. He is rousable and is taken to A&E. His partner confirms that if he has taken all of the pills it would have been in the last 6 hours.

  1. What features may be seen after the overdose and then subsequently over the following two-three days?
A
  • Jaundice
  • Nausea and vomiting
  • Multi-systemic organ failure
  • Death
  • Respiratory depression
33
Q

Case 3

A 36 year old male with a history of depressive illness and alcohol dependence has been prescribed a compound analgesic (co-codamol 30/500) for a severely sprained ankle. 24 hours after collecting his prescription he is found by his partner asleep on the sofa next to the empty packet of pain killers and 6 empty strong cider cans. He is rousable and is taken to A&E. His partner confirms that if he has taken all of the pills it would have been in the last 6 hours.

  1. Describe the appropriate pharmacological treatments that should be initiated in this patient. How do they work?
A
  • Naloxone

- Acetylcysteine

34
Q

Case 3

A 36 year old male with a history of depressive illness and alcohol dependence has been prescribed a compound analgesic (co-codamol 30/500) for a severely sprained ankle. 24 hours after collecting his prescription he is found by his partner asleep on the sofa next to the empty packet of pain killers and 6 empty strong cider cans. He is rousable and is taken to A&E. His partner confirms that if he has taken all of the pills it would have been in the last 6 hours.

  1. Beyond the potential overdose, are there any additional concerns that need to be considered in relation to the size of the overdose?
A
  • Was this intentional or accidental?
35
Q

Case 3

A 36 year old male with a history of depressive illness and alcohol dependence has been prescribed a compound analgesic (co-codamol 30/500) for a severely sprained ankle. 24 hours after collecting his prescription he is found by his partner asleep on the sofa next to the empty packet of pain killers and 6 empty strong cider cans. He is rousable and is taken to A&E. His partner confirms that if he has taken all of the pills it would have been in the last 6 hours.

  1. Although guidance is provided, evidence for the precise dose and route of administration of medication to treat opioid overdose is lacking. Why do you think this may be the case?
A

Rarely present knowing how much they’ve taken and how far through the metabolism you are.