Session 1 Carciongenesis Flashcards
1
Q
How does cooking over a flame cause cancer?
A
Produces polyaromatic hydrocarbons
Benzoapyrene is activated and adducts to DNA, often P53
2
Q
Define chemoprevention
A
Chemoprevention = inhibition, retardation or reversal of the carcinogenic process by the use of pharmacological agents
3
Q
List as many forms of mutation as you can
A
Alteration of bases Strand breaks Base oxidation Deletion of bases Deletion of chromosome fragments Adducts form b/w carcinogen & base Chromosome translocation Gene amplification Insertion by a virus
