Session 02 - Affective Disorders Flashcards
What is an affective disorder?
A mood disorder characterised by emotional disturbances, which results in functional impairment.
Biological causes of affective disorders.
5-HT: low levels of endogenous 5-HT and Na are thought to decrease mood.
Cortisol: overactivation of the HPA axis increases both risk and persistence of low mood.
Psychological causes of affective disorders.
Beck’s triad: negative views about the self, the world and the future seen in depression.
Attributional style: higher incidence in people who blame themselves for life events.
Social causes of affective disorders.
Stress: linked to negative life events, adversity and childhood stress.
What is depression?
An affective disorder characterised by low mood, leading to functional impairment and emotional distress.
Core symptoms of depression.
- low mood (often worst in morning)
- anhedonia (loss of interest in activities)
- reduced energy (fatigue)
Other symptoms of depression.
- less concentration / attention
- increased guilt and unworthiness
- changes in appetite with weight change
- sleep disturbance (early morning waking)
- suicidal ideation
- psychomotor activity changes
What additional symptoms may be observed in severe depression?
Severe depression can lead to psychotic symptoms (e.g. delusions and hallucinations).
Delusions are typically mood-congruent, including delusions of guilt, poverty, that they are dead.
Hallucinations will also usually be of defamatory voices, or the smell of rotting / decomposing flesh.
What are the core symptoms of depression in children?
Low mood or irritable mood.
How does depression present in the elderly?
Depression can present similarly to dementia, giving issues with memory.
In depression, memory loss is more rapid and causes biological symptoms. Patients are also usually aware and worried of their memory loss.
How is depression diagnosed?
Patients require at least 2/3 core symptoms which last at least two weeks.
Mild = 2 core symptoms + 2 or more other symptoms.
Moderate = 2 core symptoms + 4 or more other symptoms.
Severe = 3 core symptoms + 5 or more other symptoms.
Which tests can be used to objectively score depression?
PHQ9 is used to grade depression. It asks patients to report over the last 2 weeks how often they have been experiencing symptoms.
Mild = 5-9
Moderate = 10-14
Moderate/Severe = 15-19
Severe = >19
How is depression managed?
Mild - guided self-help or structured group physical activity programme.
Moderate or severe - first line is CBT / IPT and SSRI (continue until well for 6 months).
If multiple treatments have failed, ECT or deep brain stimulation of subgenual cingulate cortex.
In an emergency, call the community team or Crisis Resolution and Home Treatment Team (CRHTT).
What precautions should be made when prescribing SSRIs?
A side effect of SSRIs is increased suicidal thoughts initially, so review within 2 weeks.
In children, avoid SSRIs and use fluoxetine first line.
What are the broad areas of risk to assess in a psychiatric consultation?
- risk to self
- risk from others
- risk to others
Subdivisions of risk to self.
- personal safety
- personal health
How can you assess personal safety?
Ask the patient if they are experiencing any thoughts of. harming themselves, and whether they plan to act on these thoughts.
It is also important to ask about deliberate self-harm, which some patients may undertake not with suicidal intent but as a way of managing overwhelming and difficult emotions.
What questions should you ask someone who has attempted to harm themselves?
Check for any delusions of control or command hallucinations.
Clarify details about the method of the attempt of self-harm / suicide.
Were any preparations made?
Did they make attempts not to be found?
Did they make a will or leave a note?
Was the attempt planned or an impulsive action?
What was their assessment of lethality?
Did alcohol play a role at all?
How do they feel about the attempt now?
Do they have any further plans to harm themselves?
Can they identify any protective factors?
Are there any risk factors in the history?
Risk factors for suicide.
- family history of suicide
- precipitating triggers
- psychosocial stressors (e.g. financial worries, housing insecurity)
- recent losses
- social isolation
- early morning waking*
How can you assess personal health?
Does the patient use alcohol or drugs as a way of managing difficult feelings or memories?
Consider personal hygiene, nutrition and safety.
Query concordance with medications and attending appointments.
How can you assess risk from others?
Consider whether there are any safeguarding concerns.
It is important to remember to ask about domestic violence and abuse.