Serotoninergic Neurotransmission Flashcards
Where is the localization of serotoninergic system?
consists of ascending axons from cell bodies in the raphe nuclei
Scheme of serotoninergic axon terminal
Tryptoph
What is the KM of tryptophan hydroxylase?
30-60 µM
in thr brain the enzyme is not saturated
How is tryptophan hydroxylase regulated?
short term regulation: via phosphorylation (CAMK II, PKC)
long term regulation: synthesis of the enzyme is increased
What happens to the amount of tryptophan hydroxylase during the day time?
the amount of the enzyme in the pineal gland decreases
What happens to the amount of tryptophan hydroxylase during the night time (darkness)?
increased sympathetic activity
↓
β receptor activation in the pineal gland
↓
cAMP
↓
acetyltransferase activation
↓
increased synthesis of melatonin
What are the serotonin transporters?
synaptic vesicles
SERT
(synaptic plasmamembrane transporter)
What do amphetamine derivatives such as Fenfluramine or Ecstasy inhibit?
