Serotonergic/NE Flashcards
what are the other names for serotonin?
5-HT
5-hydroxytryptamine
what amino acid is serotonin synthesized from?
tryptophan
what kind of transporter involved in getting serotonin inside the nerve terminal?
Na+ coupled (with tryptophan) Aromatic L-amino acid transporter.
this is a symporter
what happens to tryptophan once inside the nerve terminal?
it gets converted to 5-hydroxytryptophan via Tryptophan Hydroxylase by adding a hydroxyl group
this is a rate-limiting step
what happpens after 5-hydroxytryptophan is made?
it gets further converted into 5-hydroxytryptamine aka 5-HT aka Serotonin
what enzyme convert 5-hydroxytryptophan to serotonin?
aromatic l-amino acid decarboxylase
by removing a carboxyl forming a monoamine at the end
is serotonin a monoamine?
yes
is serotonin a catecholamine?
no
what transporter transport serotonin into the vesicle?
VMAT powered by V-ATPase
also using a proton gradient
is VMAT selective or non-selective?
non-selective
it transport all monoamines
what happens when serotonin nerve is activated?
an action potential is generated
what happens when an action potential is generated?
Ca2+ influx causing exocytosis –> serotonin release
how can serotonin be deactivated after transmission?
reuptake back into the presynaptic nerve terminal via SERT or degraded by MAO
how many total number of serotonin receptors are identified?
14
how many serotonin receptors are in the brain?
13