Serological markers

Question 1

RF (rheumatoid factor) (3)

Answer 1

Sjogren, Felty, RA

Question 2

anti-CCP (anticyclic citrullinated peptide)

Answer 2

RA (high specificity)

Question 3

ANA (antinuclear antibody)

Answer 3

SLE, AIH

Question 4

anti-dsDNA (anti-double-stranded DNA)

Answer 4

SLE (high specificity)

Question 5

anti-histone DNA

Answer 5

drug-induced SLE

Question 6

anti-phospholipid Ab (anti-cardiolipin Ab, lupus anticoagulant, anti-β2-glycoprotein)

Answer 6

anti-phospholipid syndrome, SLE

Question 7

anti-centromere Ab

Answer 7

limited systemic sclerosis

Question 8

anti-Scl70

Answer 8

diffuse systemic sclerosis

Question 9

AMA (anti-mitochondrial Ab)

Answer 9

PBC

Question 10

anti-SMA (anti-smooth muscle Ab)

Answer 10

AIH

Question 11

gastric parietal cell Ab

Answer 11

pernicious anaemia

Question 12

intrinsic factor Ab

Answer 12

pernicious anaemia

Question 13

anti-GBM (glomerular basement membrane)

Answer 13

Goodpasture’s disease

Question 14

c-ANCA (anti-neutrophil cytoplasmic Ab)

Answer 14

Wegener’s vasculitis

Question 15

p-ANCA (anti-neutrophil cytoplasmic Ab)

Answer 15

microscopic polyangiitis, Churg-Strauss vasculitis, Goodpasture’s, IBD, PSC