Sepsis - Definition, Signs and Symptoms Flashcards
What is the definition of sepsis
Sepsis is a life-threatening organ dysfunction due to a dysregulated host response to infection
What clinical criteria differentiates sepsis from infection
Organ dysfunction
Why is sepsis associated with infection
Although it is not an infection, it doesn’t occur in the absence of infection
It is triggered by infection
What is septic shock
Sepsis with persisting hypotension that requires vasopressore to maintain the mean arterial pressure at >65mmHg and with a serum lactate concentration >2moll-1
What is qSOFA
A tool to clinically characterise patients at risk of sepsis
What would score 1 using the quick SOFA criteria
Elevated respiratory rate
Score of 14 on Glasgow Coma Scale
Pre-existing and poorly controlled diabetes
What would score 2 using the quick SOFA criteria
Organ dysfunction
What are common causes of sepsis
Small cut in the skin Meningitis Kidney infection Throat infection Coronavirus Urinary tract infection
What are common sources of infection that trigger sepsis
Gram positive bacteria - Staph aureus
Gram negative bacteria
Fungal - candida
Where is sepsis most prevalent
US - 65% of cases
What patients are most likely to get sepsis
Medically and immune-compromised patients: Cancer Cirrhosis Autoimmunity HIV/AIDS Organ transplantation Diabetes
