Sepsis Continuum and DIC Flashcards
A patient being admitted for knee surgery says, “Everyone in my office is sick all of the time, but I never get sick.” How would the nurse evaluate this statement?
- The patient may have a strong antigen–antibody response.
- This patient’s poorly differentiated histocompatibility antigens may be a problem during postoperative recovery.
- The patient’s coworkers must have immune system compromise.
- The patient must have strong passive immunity.
Correct Answer: 1
Rationale 1: Normally, an antibody circulates in the bloodstream until it encounters an appropriate antigen to bind. This binding results in antigen–antibody complexes, or immune complexes. The process of binding is such that the antibody binds to specifically conformed antigenic determinant sites on the antigen, which prevents the antigen from binding to receptors on host cells. The outcome is the host is protected from an infection.
Rationale 2: Histocompatibility antigens are surface antigens which are genetically determined and are proteins found on the surface of a cell. These antigens would not impact the patient’s inability to get colds or other illnesses, nor would they cause complications postoperatively.
Rationale 3: Immune system compromise does result in frequent illnesses, but there is not enough information for the nurse to make this determination.
Rationale 4: Passive immunity is a temporary immunity involving the transfer of antibodies from one individual to another or from some other source to an individual. Passive immunity can be transferred also through vaccination either of antiserum, an antitoxin, or as gamma globulin.
A patient being evaluated for septic shock has a serum lactate level of 5 mmol/L. What intervention does the nurse anticipate?
- Decreasing the amount of oxygen being given
- Immediate initiation of fluid resuscitation
- Repeat of the testing in 4 hours
- Bedside fingerstick level of blood glucose
Correct Answer: 2
Rationale 1: An increased serum lactate calls for increased oxygenation.
Rationale 2: A lactate level of 4 mmol/L is suspicious of significant tissue hypoperfusion and requires immediate fluid resuscitation.
Rationale 3: There is no need to repeat this test before intervening.
Rationale 4: Measuring blood glucose is not indicated by this lab result.
A patient admitted to the emergency department following chest trauma has tracheal deviation to the left. The nurse would prepare for which emergency medical intervention?
- Open thoracotomy
- Placement of a chest tube
- Open excision of the pericardial sac
- Immediate cardiopulmonary resuscitation
Correct Answer: 2
Rationale 1: Open thoracotomy is not indicated for this complication.
Rationale 2: Tracheal deviation can result from mediastinal shifting due to a tension pneumothorax. Treatment is placement of a chest tube or a needle thoracotomy.
Rationale 3: Excision of the pericardial sac may be indicated when cardiac tamponade exists. There is no indication that this complication has developed.
Rationale 4: There is no indication that cardiopulmonary resuscitation is needed at this point.
The nurse caring for a patient with an infected leg wound realizes that neutrophils and macrophages will arrive to the wound as a part of the natural body response. How would the nurse explain this process to the patient?
- “Your white blood cells will travel through your lymph system to the wound.”
- “Chemical signals from the injured tissue help guide the white blood cells to where they are needed.”
- “Only the white blood cells already in your system will be able to fight this infection.”
- “The white blood cells attach to red blood cells for transport to the wound.”
Correct Answer: 2
Rationale 1: The white blood cells do not travel through the lymph system.
Rationale 2: Circulating neutrophils and monocytes have to arrive where they are needed and then they must be able to transfer from the blood vessels to the site of injury. After the leukocyte is outside the capillary, it requires guidance to move to the correct location. This is accomplished through chemotaxis, which refers to movement as a result of some type of chemical stimulus.
Rationale 3: Infection stimulates the production of additional white blood cells.
Rationale 4: White blood cells are independent of red blood cells.
Which finding would cause the nurse to be concerned that a patient who sustained chest trauma is experiencing cardiac tamponade?
- Distant heart sounds
- Decrease of right arterial pressure
- Sudden development of hypertension
- Development of an S3 heart sound
Correct Answer: 1
Rationale 1: The presence of blood in the pericardial space makes the heart tones sound muffled or distant.
Rationale 2: Right arterial pressure increases with cardiac tamponade.
Rationale 3: Hypotension is associated with cardiac tamponade due to the heart’s inability to fill.
Rationale 4: S3 heart sounds are not associated with cardiac tamponade.
A patient in shock has just been started on IV Dopamine at 5 mcg/kg/min. Which findings would the nurse evaluate as indication of a possible adverse effect of this therapy? (select all that apply)
- Persistent hypotension
- Heart rate 118
- Development of a bundle branch block
- Drop in urine output
- Mottling of extremities
Correct Answer: 2,3,4,5
Rationale 1: The rate of infusion of dopamine can be increased above that which is being given if hypotension is not resolved. This is not an adverse effect but may be a case of not getting enough drug. If the patient remains hypotensive at higher infusion rates (50 mcg/kg/min), an adverse effect may be occurring.
Rationale 2: Tachycardia can be an adverse effect of dopamine.
Rationale 3: Aberrant cardiac conduction may indicate an adverse drug effect is occurring.
Rationale 4: Tissue ischemia is an adverse effect of dopamine. Decreased blood flow to the kidney will cause decrease in urine output.
Rationale 5: Mottling of extremities indicates peripheral ischemia.
A patient was admitted to the emergency room for treatment of severe infection. Which objective parameters would increase the nurse’s concern that shock is developing? (select all that apply)
- Serum lactate level is 5.4 mmol/L.
- Base deficit is -12 mmol/L.
- SvO2 is 68%.
- pHi is 6.9.
- Arterial pH of 7.38.
Correct Answer: 1,2,4
Rationale 1: Lactate is the metabolic byproduct of pyruvate, which is formed as the result of anaerobic metabolism. Elevated levels mean that the body is depending, at least to some part, on anaerobic metabolism rather than the normal aerobic metabolism.
Rationale 2: This is a moderate base deficit and indicates buildup of lactic acidosis resulting from impaired tissue oxygenation.
Rationale 3: Normally, when oxygen supply and demand are in balance, hemoglobin is about 60% to 80% saturated after leaving the tissues.
Rationale 4: Low mucosal pH indicates development of acidosis.
Rationale 5: This is a normal arterial pH.
A patient was admitted through the emergency department with fractures of the skull, ribs, and both femurs sustained from a motor vehicle accident. The nurse provides care based upon changes in which pathophysiological process?
- Formation of red blood cells
- Cellular and humoral immune responses
- Formation of plasma
- Antigen–antibody formation
Correct Answer: 1
Rationale 1: Blood cells are formed in the bone marrow which exists within all bones. Because the patient sustained fractures to the skull, ribs, and both femurs, red blood cell formation will be impacted.
Rationale 2: Cellular and humoral immune responses occur in secondary lymphoid organs such as the tonsils, adenoids, lymph nodes, and spleen. This patient’s injuries are not focused in these areas.
Rationale 3: Plasma is a clear fluid that remains once all of the blood cells are removed. Formation of plasma should not be affected by these injuries.
Rationale 4: Antigen–antibody response is what occurs when an infectious organism is introduced into the body. The ability to mount this response will continue despite these injuries.
A patient suffered severe trunk and lower extremity injury in a motor vehicle accident. Which injuries would indicate to the nurse that this patient may have dysfunction of normal hemostasis? (select all that apply)
- Contusion of the spleen
- Laceration of the liver
- Femur fractures
- Bruising of the heart
- Pneumothorax
Correct Answer: 1,2,3
Rationale 1: The spleen provides storage for platelets. If the spleen is damaged and unable to hold or release platelets, normal hemostasis will be disrupted.
Rationale 2: The liver produces most of the clotting factors so injury would affect normal hemostasis.
Rationale 3: The marrow of long bones support blood cell development. This patient may have disruption of all three cell lines.
Rationale 4: Bruising of the heart should not affect hemostasis.
Rationale 5: Pneumothorax should not affect hemostasis.
A patient hospitalized for treatment of a severe urinary tract infection may be developing septic shock. The nurse would monitor for the development of which finding associated with early septic shock?
- Cold extremities
- Increase in serum lactate levels
- Decreased SCVO2
- Widening of pulse pressure
Correct Answer: 4
Rationale 1: Cold and mottled extremities are associated with later stages of septic shock.
Rationale 2: Increased serum lactate levels indicate a later stage of shock.
Rationale 3: Decreased SCVO2 indicates a later stage of shock.
Rationale 4: Since the patient’s diastolic blood pressure decreases, the pulse pressure increases. This finding is associated with early stages of septic shock.
The nurse is assessing a patient being treated for neurogenic shock after a spinal cord injury. Which assessment would the nurse evaluate as patient improvement?
- Temperature of 97.8°F
- Heart rate of 70 bmp
- Resistance to ventilator-assisted breaths.
- Pink skin tone
Correct Answer: 2
Rationale 1: Hypothermia is one of the triad of expected signs of neurogenic shock. This patient remains hypothermic.
Rationale 2: Bradycardia is one of the triad of expected signs of neurogenic shock. Return to a normal heart rate is a sign of improvement.
Rationale 3: Respiratory rate is not one of the triad of expected findings associated with neurogenic shock. The patient may be mechanically ventilated, but a change in acceptance of this assistance is not indicative of an improved shock status.
Rationale 4: Peripheral vasodilation produces a pink skin tone so this finding does not indicate improvement.
A patient who has been receiving norepinephrine (Levophed) at a rate of 10 mcg/min will have the drug discontinued. How should the nurse plan to manage this intervention?
- Stop the infusion, but leave normal saline infusing at a rate to keep the vein open.
- Stop the infusion and place an intermittent infusion cap on the IV access device.
- Decrease the rate to 5 mcg/min for 30 minutes before discontinuing the infusion.
- Decrease the rate by 1 mcg/min every 30 minutes while monitoring the patient’s response
Correct Answer: 4
Rationale 1: Abrupt withdrawal of this medication is not indicated.
Rationale 2: Abrupt withdrawal of this drug is not indicated.
Rationale 3: The infusion rate should not be abruptly lowered.
Rationale 4: The nurse should decrease the infusion slowly, while monitoring the patient’s response. This is the only response that does not result in abrupt withdrawal of the medication
A patient is being evaluated for a kidney transplant. Which individual is most likely the best candidate to donate this organ?
- A live donor from a donor bank
- Live kidney transplant from the patient’s spouse
- Cadaver kidney transplant
- Live kidney transplant from a brother
Correct Answer: 4
Rationale 1: A person willing to donate a kidney, but who is unrelated to the recipient, is not likely to be a match.
Rationale 2: A spouse may or may not be a match for this donation.
Rationale 3: Cadaver kidneys may or may not match the donor.
Rationale 4: Because full siblings share the same biological parents, they often have some degree of human leukocyte antigen matching. The closer the human leukocyte antigen combination matches between two people, the more the “fingerprint” is recognized as self.
A patient’s admission laboratory work reveals a platelet count of 90,000/mcL. Which interventions should the nurse implement? (select all that apply)
- Implement bleeding precautions.
- Monitor urine output.
- Limit the ingestion of green leafy vegetables.
- Restrict fluids.
- Review the patient’s medication history.
Correct Answer: 1,5
Rationale 1: Platelets play a crucial role in hemostasis or blood clotting. Since the normal platelet count in an adult is 150,000 to 400,000/mcL, a count of 90,000/mcL means the patient is prone to bleeding. Bleeding precautions should be implemented for this patient.
Rationale 2: There is no evidence that monitoring urine output is an essential part of this patient’s care.
Rationale 3: Green leafy vegetables contain vitamin K which is needed by the liver to form coagulation factors. Since these factors are needed for the coagulation cascade, vitamin K should not be limited in this patient.
Rationale 4: There is no evidence to suggest that fluids should be restricted for this patient.
Rationale 5: Medications can be implicated in low platelet counts, so reviewing medication history is indicated.
A patient was admitted to the emergency department for treatment of a severe infection. Which subjective assessment would raise the nurse’s concern that this patient may be developing shock?
- Hot, dry skin
- Respiratory rate 11
- Pulse rate 118 and weak
- Anxiety
Correct Answer: 3
Rationale 1: Hot, dry skin is the expected assessment when a patient is febrile, which may be the case with severe infection.
Rationale 2: Typically rapid breathing occurs in the presence of shock. This response is an attempt to add oxygen to the system.
Rationale 3: Rapid pulse occurs in an attempt to increase blood flow, thereby increasing oxygenation to tissues. Weak pulses occur as the contractility of the heart decreases.
Rationale 4: Anxiety can occur for a variety of reasons and would not immediately be associated with a shock state.
The nurse is monitoring a patient at risk for development of left ventricular failure and cardiogenic shock. Which findings would the nurse immediately discuss with the primary health care provider? (select all that apply)
- Development of an S3 heart sound
- Sustained systolic hypertension
- Development of bilateral crackles
- Decrease in PAWP
- Decrease in cardiac index
Correct Answer: 1,3,5
Rationale 1: Development of third or fourth heart sounds may indicate development of left ventricular failure.
Rationale 2: Sustained systolic hypotension would indicate development of left ventricular failure.
Rationale 3: Increased pulmonary congestion, as manifested by development of bilateral crackles, may indicate that left ventricular failure is developing.
Rationale 4: Left ventricular failure would be manifested by elevation of PAWP.
Rationale 5: Low cardiac index can indicate development of left ventricular failure.