Sepsis and shock Flashcards
Score system for patinets risk in sepsis
qSOFA
Define SIRS
2 or more of:
- Temperature < 36°C or > 38°C
- Heart rate > 90 beats/min
- Respiratory rate > 20 or PaCO2 less than 4.5 kPa ormechanically ventilated
- White Cell Count < 4 or > 11 or > 10%immature forms
Define sepsis
SIRS plus documented or suspected infection
Define Septic shock
Sepsis with hypotension (Systolic blood pressure <90mmHg or need for vasopressor infusion) despite adequate fluid resuscitation
Name 3 non infective causes of SIRS
- Burns Trauma Pancreatitis Cardiopulmonary bypass - Massive transfusion.
What are Toll like receptors for
recognition of molecules Eg lipopolysaccahride on microorganisms
What happens when toll like receptors activated
Activate transcription factors eg Nuclear factor kappa beta -> secretion of pro/antiinflammatory mediators
Name 2 inflammatory mediators
Interleukins 1,2 and 6
Tumour necrosis factor alpha
What do inflammatory mediators do
Activate leukocytes
activate coagulation cascade
endothelial damage
synthesize NO -> vasodilation and poor perfusion
How much fluid in septic shock
30ml/kg in first 3 hours
Sepsis in ITU hour 1
Measure lactate level*
Obtain blood cultures before administering antibiotics.
Administer broad-spectrum antibiotics.
Begin rapid administration of 30mL/kg crystalloid for hypotension or lactate level ≥ 4 mmol/L.
Apply vasopressors if hypotensive during or after fluid resuscitation to maintain MAP ≥ 65 mm Hg.
- Remeasure lactate if initial lactate is elevated (> 2 mmol/L)
Additional sepsis considerations
Hydrocortisone 200mg IV once daily if adequate fluid resus / vasopressors and still haemodynamic instability
Keep glucose <10mmol
Define shock
circulatory insufficiency with inadequate oxygen delivery resulting in hypoperfusion and tissue hypoxia
Essentialy DO2
Vasopressor 1st line in shock
For shock of unknown cause ?
For septic shock?
For cardiogenic shock?
For shock of unknown cause use adrenaline.
For septic shock use noradrenaline.
For cardiogenic shock use dobutamine.
Where does the sympathetic autonomic system originate?
Sympathetic autonomic nervous system originates from T1-L2
After originating in T1-L2 where does the sympathetic autonomic system go
- connect through synapses to postganglionic neurons.
- These synapses are located in the two sympathetic chains that lie on either side of the vertebral column
Main parasympathetic nerve? Where are key parasympathetic ganglia?
Which key receptor in parasympathetic system
Vagus
- Parasympathetic ganglia are embedded in the heart, mainly on the SA and AV nodes
- ß2receptors are present on other organs, stimulation causes relaxation e.g. of bronchial and uterine smooth muscle.
