Sepsis and Septic Shock

Question 1

Sepsis and Septic Shock

Answer 1

are clinical syndromes that typify the interplay of the microorganism and its virulence factors with the host and its inflammatory response

Question 2

Sepsis

Answer 2

is a term gennerally used to describe a complex of fever, tachycardia, and tachypnea in assocaitin with local or systemic infection. It is an acute inflammatory disorder, and a leading cause of critical illnes and mortality worldwide

Question 3

Oxidative stress and Sepsis

Answer 3

one of the hallmarks

and nitric oxide plays an important role in the generation of reactive intermediates that contribute to sepsis-mediated organ dysfunciton

Question 4

Mediators of sepsis

Answer 4

endotoxin= LPS or the inflammatory cytokines TNFa, IL-1 and IFNg have been shown…….

Question 5

lipid peroxidation

Answer 5

allylic hydrogen atom of fatty acids may be abstracted to created a carbon centred radical

makes a hydroperoxide radical

three stages

innitiation, propogation, termination

Question 6

end products of lipid peroxidation

Answer 6

reactive aldehydes

MDA malondialdehyde = malonic acids

4-HNE = 4- hydroxynonenal